13 results about "Herba Scutellaria Barbata" patented technology

The invention provides a broad-spectrum combined medicine for treating colorectal cancer. The broad-spectrum combined medicine is prepared from the following components in parts by weight: 100 parts of purified water, 38 to 90 parts of tripterygium wilfordii alkaloid, 38 to 90 parts of tripterygium hypoglaucum alkaloid, 28 to 85 parts of chamaejasmine, 28 to 85 parts of gelsmium elegans alkaloid and 28 to 85 parts of xanthoxylin. The medicine is prepared from the following raw materials in parts by weight: 16 to 80 parts of ganoderan, 16 to 80 parts of pinellia ternate sitosterol, 16 to 80 parts of radix rehmanniae praeparata, 16 to 80 parts of astragaloside, 16 to 80 parts of oldenlandia diffusa alkaloid, 16 to 80 parts of sculellaria barbata alkaloid, 16 to 80 parts of tanshinone, 16 to 80 parts of carthamin, 16 to 80 parts of honeysuckle chlorogenic acid and 16 to 80 parts of pericarpium citri reticulatae flavone. By integrating anti-tumor components with multiple action mechanisms, tripterygium wilfordii alkaloid, tripterygium hypoglaucum alkaloid and the like, tumor cell proliferation can be directly inhibited, and apoptosis can be induced; tanshinone, emodin and the like can inhibit tumor angiogenesis; ganoderma lucidum polysaccharides, astragaloside and the like can activate the immune system of the body, enhance the activity of T cells and NK cells, and form double strikes of direct killing and immune surveillance.

The invention provides an anti-cancer medicine and food homologous composition and a preparation method thereof. The composition is prepared from the following components in parts by weight: 5 to 10 parts of lipoic acid, 30 to 50 parts of nano curcumin, 2 to 7 parts of berberine, 50 to 100 parts of beta-glucan, 15 to 35 parts of polymethylacrylic acid, 15 to 25 parts of herba hedyotidis diffusae extract, 7 to 15 parts of scutellaria barbata baicalein, 25 to 55 parts of astragalus polysaccharide, 8 to 18 parts of coix seed ester and 10 to 15 parts of cordyceps cicadae. Through a space-time targeting synergistic release mechanism of a bionic nanocellulose skeleton and in combination with pH / enzyme double-response intelligent regulation and control, three-stage precise synergistic effects of oxidation resistance, apoptosis promotion and immune activation are realized, the limitation that a traditional medicinal and edible composition is poor in targeting property, low in synergistic efficiency and uncontrollable in toxicity is broken through, and the medicinal and edible composition has a broad application prospect. High-efficiency and low-toxicity tumor multi-channel synergistic intervention is achieved in a natural component system for the first time, and the actual effect of the whole medicinal and edible composition on cancer and swelling resistance is improved.

The present application relates to a kind of anti-non-small cell lung cancer for strengthening healthy qi and resolving stasis and preparation method thereof, strengthening healthy qi and resolving stasis is made from the following weight proportion of raw medicinal materials: Ficus pumila 2g~50g / portion, radix pseudostellariae 2g~50g / portion, poria cocos 2g~50g / portion, atractylodes 2g~50g / portion, radix scutellariae 2g~50g / portion, oldenlandia 2g~50g / portion, cat's paw grass 2g~50g / portion, giant knotweed 2g~50g / portion, curcuma zedoary 2g~50g / portion, oyster 2g~50g / portion, platycodon 2g~50g / portion, mountain bitterling 2g~50g / portion, half branch orchid 2g~50g / portion. By cell test and the construction NSCLC osimertin drug resistance animal model prove, strengthening healthy qi and resolving stasis of the present application can adjust tumor microenvironment (TME) and inhibit non-small cell lung cancer cell growth of osimertin drug resistance. Not only this, strengthening healthy qi and resolving stasis of the present application can also inhibit common non-small cell lung cancer cell growth. While clinical observation finds, strengthening healthy qi and resolving stasis of the present application can improve insomnia, skin rash, diarrhea and other symptoms of lung accumulation (lung cancer, lung nodule) patient, improve its quality of life.

The invention relates to application of a traditional Chinese medicine composition in preparation of a medicine for preventing or treating myelodysplastic syndrome and related complications thereof. The traditional Chinese medicine composition comprises sculellaria barbata, astragalus membranaceus, angelica sinensis, nightshade, radix curcumae, red ginseng, duchesnea indica, saussurea involucrata, cyclea verticillata and salvia miltiorrhiza. The traditional Chinese medicine composition has a good prevention and treatment effect on myelodysplastic syndrome and related complications thereof, can effectively inhibit proliferation of hematological tumor cells, and also can inhibit proliferation of the myelodysplastic syndrome by increasing the hemoglobin level, reducing the inflammatory cytokine level and reducing the proportion of peripheral blood T cells. Anemia, inflammation and low immune function caused by the myelodysplastic syndrome can be treated. The invention provides an effective strategy for prevention or treatment of myelodysplastic syndrome and related complications thereof, and provides a new direction for application of the traditional Chinese medicine composition.

The invention relates to a compound medicine for treating oral mucositis caused by luconobutuzumab and a preparation method of the compound medicine, and the compound medicine realizes the comprehensive curative effects of resisting inflammation, easing pain and promoting mucosal repair through combination of traditional Chinese medicines and western medicines and synergism of multi-ethnic medicines. The compound medicine is prepared from the following components in parts by weight: 0.1 to 0.5 part of recombinant human epidermal growth factor, 0.5 to 2.0 parts of lidocaine, 0.01 to 0.1 part of vitamin B12, 1.0 to 5.0 parts of astragalus polysaccharide, 0.5 to 3.0 parts of honeysuckle chlorogenic acid, 0.2 to 1.5 parts of glycyrrhizic acid, 0.1 to 1.0 part of crocin, 0.3 to 2.0 parts of saussurea involucrata flavone, 0.2 to 1.8 parts of paris polyphylla saponin and 0.4 to 2.5 parts of sculellaria barbata flavone. The compound provided by the invention is suitable for tumor patients receiving treatment of luconatobutuzumab, is especially suitable for patients suffering from I-III grade oral mucositis, can be used as a hospital preparation or new drug development, and has wide clinical application and market prospects.

The invention discloses a ginseng-astragalus compound composition as well as a preparation method, application and a traditional Chinese medicine preparation thereof. The radix codonopsis and radix astragali compound composition comprises 25-35 parts of radix astragali, 15-25 parts of radix codonopsis, 5-15 parts of fried rhizoma atractylodis macrocephalae, 5-15 parts of poria cocos, 10-20 parts of fried malt, 10-20 parts of fried rice sprout, 5-15 parts of fried endothelium corneum gigeriae galli, 25-35 parts of sculellaria barbata, 10-20 parts of oldenlandia diffusa, 1-11 parts of fried gecko, 4-14 parts of vinegar-processed curcuma zedoary, 4-14 parts of sappan wood, 5-15 parts of radix curcumae, 5-15 parts of vinegar-processed rhizoma cyperi, 5-15 parts of salt-processed semen cuscutae, 5-15 parts of glossy privet fruit and 1-10 parts of liquorice. The ginseng and astragalus compound composition, the ginseng and astragalus compound extract or the traditional Chinese medicine preparation can inhibit the growth of tumor cells, and especially can inhibit the growth of gastric cancer cells.

The invention discloses an anti-cancer and anti-cancer cell repair honeyed bolus, which is prepared from the following medicinal materials: radix salviae miltiorrhizae, turtle shell, black nightshade herb, solanum lyratum thunb, rattan root, spica prunellae, sculellaria barbata, pseudo-ginseng, liquorice root, herba houttuyniae and radix astragali seu hedysari, relates to the technical field of cancer adjuvant therapy, can induce cancer cell differentiation, inhibit cancer cell proliferation and prevent metastasis and relapse, is beneficial to alleviation of side effects of radiotherapy and chemotherapy, and has a good anti-cancer effect. The immunity of the patient is enhanced.

This invention discloses a medicinal ointment for treating Qi deficiency and blood stasis syndrome and its preparation method. The raw materials of the medicinal ointment include: ginseng, atractylodes macrocephala, astragalus membranaceus, rehmannia glutinosa, dandelion, chuanxiong rhizome, costus root, turmeric, salvia miltiorrhiza, peucedanum praeruptorum, apricot kernel, sparganium rhizome, scutellaria barbata, oldenlandia diffusa, licorice, and gelatinous medicinal materials. The preparation method involves decocting the medicinal formula and then adding gelatinous materials to form the ointment. This invention improves the loss of appetite and fatigue in mice with non-small cell lung cancer syndrome caused by Qi deficiency and blood stasis syndrome by modifying the traditional Chinese medicine formula and preparing it as an ointment. It reduces whole blood and plasma viscosity by tonifying Qi, activating blood circulation, and removing blood stasis, thus promoting blood flow without damaging hepatocytes and reducing the toxic side effects of the formula on the liver. Furthermore, the ointment preparation makes it convenient for patients to carry and take.

The invention provides an extraction and separation method of sculellaria barbata general flavone, and belongs to the technical field of extraction and separation. Comprising the following steps: S1, adding sculellaria barbata powder into an extracting solution, heating, performing ultrasonic extraction, filtering, and performing vacuum concentration to obtain a sculellaria barbata extracting solution; s2, adding the sculellaria barbata extracting solution into petroleum ether for extraction, oscillating, standing and layering, and reserving a lower-layer water phase as a degreased flavone enrichment solution; s3, extracting the degreased flavone enrichment liquid and a petroleum ether / ethyl acetate mixed liquid for multiple times, separating and taking an upper ethyl acetate phase, combining, and removing a solvent under reduced pressure to obtain an extraction liquid; s4, carrying out static adsorption on the extract and the modified resin microspheres, eluting with an ethanol solution after adsorption saturation, collecting the eluate, and removing the solvent under reduced pressure to obtain a purified solution; and S5, freeze-drying the purified liquid to obtain the sculellaria barbata general flavone. According to the method, the petroleum ether and the ethyl acetate are mixed for use for extraction, the modified resin microspheres are used for purification, the extraction purity is greatly improved, and the method has the advantages of being easy to operate, mild in condition and the like.

The invention relates to the technical field of health food, and discloses a composition for sobering up, assisting in lowering lipid and improving intestinal tracts and a preparation method, the composition comprises the following components in parts by weight: 40-60 parts of rubus stems and leaves, 3-6 parts of oldenlandia diffusa, 1-3 parts of sculellaria barbata, 0.5-2 parts of balsam pear, 0.5-2 parts of radix bupleuri, 0.5-2 parts of pericarpium citri reticulatae, 0.5-2 parts of elecampane, 0.5-2 parts of raw hawthorn and 0.5-2 parts of semen plantaginis. The preparation method comprises the steps of raw material crushing, enzymolysis extraction, alcohol extraction, water extraction, spray drying and the like. Experimental verification shows that the composition has multiple effects of prolonging the drunkenness latency period, accelerating ethanol metabolism, reducing serum transaminase, regulating blood lipid indexes, improving intestinal peristalsis and flora structures and the like, and acute toxicity tests prove that the composition is high in edible safety. The composition disclosed by the invention can be used for preparing health-care foods with the effects of dispelling the effects of alcohol, assisting in lowering lipid and improving intestinal functions.

This invention discloses a traditional Chinese medicine formula for reducing toxicity and enhancing efficacy in combination with chemotherapy and immunotherapy for non-small cell lung cancer, belonging to the field of traditional Chinese medicine technology. The formula is composed of the following components by weight: Astragalus membranaceus 15-30 parts, Codonopsis pilosula 9-15 parts, Coix lacryma-jobi 15-30 parts, Poria cocos 9-15 parts, Atractylodes macrocephala (stir-fried with wheat bran) 9-15 parts, Citrus reticulata 9-15 parts, Hedyotis diffusa 15-30 parts, Scutellaria barbata 15-30 parts, Selaginella tamariscina 15-30 parts, Hedyotis diffusa 15-30 parts, Prunella vulgaris 9-15 parts, Gallus gallus domesticus (gizzard lining) 10-15 parts, stir-fried Hordeum vulgare 9-15 parts, stir-fried Hordeum vulgare 9-15 parts, and Glycyrrhiza uralensis (processed with honey) 3-6 parts. This invention can synergize with chemotherapy and immunotherapy to improve treatment efficacy and prolong survival, thus overcoming the shortcomings of existing treatments. At the same time, as a traditional Chinese medicine formula, it can significantly reduce the toxic side effects of treatment, improve the body's immune status, and relieve symptoms such as cough and chest tightness, thereby improving the patient's quality of life from multiple dimensions such as efficacy, tolerability, and physical sensation.

The invention discloses a traditional Chinese medicine compound multi-layer coated microsphere preparation for treating pancreatic cancer and a preparation method thereof. The preparation is prepared from the following active components in parts by weight: 10-35 parts of astragalus extract, 8-25 parts of ganoderma lucidum spore powder, 5-18 parts of sculellaria barbata general flavone and the like. The preparation method comprises the following steps: a) directionally extracting active ingredients; b) removing toxic substances from the dried toad skin through molecular imprinting; c) constructing three layers of coated microspheres, wherein a core layer is a nanocrystal (indirubin / chelidonine / toad peptide), a middle layer is a phospholipid complex (flavone / polysaccharide), and an outer layer is a pH response polysaccharide microsphere; and d) pressing to obtain the three-layer sustained-release tablet. The preparation realizes colon-targeted drug release, the bioavailability is obviously improved, the tumor inhibition rate of animal experiments is improved, and the chemotherapy drug resistance can be reversed.

The invention relates to the technical field of sculellaria barbata culture, in particular to a sculellaria barbata culture medium and a preparation method thereof The sculellaria barbata culture medium is prepared from an MS culture medium and a basic raw material according to the mass ratio of (6-7): 1, and the basic raw material is prepared from the following raw materials in parts by weight: 2-4 parts of novel nano silicon dioxide, 0.05-0.08 part of cerous nitrate, 1-2 parts of an organic fungicide, 0.7-0.8 part of 6-benzyladenine, 0.2-0.4 part of alpha-naphthylacetic acid, 0.1-0.3 part of jasmonic acid methyl ester and 2-4 parts of a functional additive. According to the invention, cell wall stability is enhanced and hormone slow release regulation is realized through novel nano silicon dioxide, and cerium nitrate is improved to activate a flavonoid compound synthetase system; the organic fungicide inhibits pathogenic bacteria and promotes nitrogen conversion by secreting lipopeptide antibiotics and nitrogenase systems; and the functional auxiliary agent realizes efficient retention and stable release of the active components.