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Stabilizing composition containing triethyl citrate and glycine

A technology of triethyl citrate and composition, applied in the field of stable compositions containing triethyl citrate and glycine, capable of solving problems such as urea instability limiting application

Active Publication Date: 2021-03-19
SHANGHAI JAHWA UNITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the instability of urea severely limits its application in cosmetics

Method used

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  • Stabilizing composition containing triethyl citrate and glycine
  • Stabilizing composition containing triethyl citrate and glycine
  • Stabilizing composition containing triethyl citrate and glycine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-22

[0089] Examples 1-22: Preparation of urea-containing compositions

[0090] Weigh an appropriate amount of raw materials according to the weight shown in Table 1-3, add them to a 50ml PET sealed plastic bottle, weigh an appropriate amount of deionized water, add the PET sealed plastic bottle, seal the PET sealed plastic bottle, and shake until the solid is completely dissolve. After the solid is completely dissolved and mixed evenly, measure the pH value of the sample. If the initial pH value is higher than 7, add citric acid solution to make the pH value of the sample reach about 6.

[0091] Table 1

[0092]

[0093] Table 2

[0094]

[0095] table 3

[0096]

[0097] The dosage unit of each component in the above examples is g.

[0098] The above-described embodiments can be divided into four groups:

[0099] (1) Example 1-Example 4: urea background, use of triethyl citrate or glycine alone, and comparison of the effects of using triethyl citrate and glycine aft...

Embodiment 18- Embodiment 22

[0102] (4) Example 18-Example 22: The content of triethyl citrate and glycine was fixed, and the effects of electrolytes, excessive metal ions, and solid powder on the pH value of urea aqueous solution were investigated.

[0103] Due to the good solubility of urea, triethyl citrate, and glycine, most of the samples can be completely dissolved by shaking a few times to form a transparent and clear solution. Exceptions include, Example 19, which was dark blue due to the addition of copper salt, and Examples 21 and 22, which appeared as suspensions due to the addition of water-insoluble powder.

[0104] The pH of most samples after preparation is between 4.0 and 7, and there is no need to adjust the pH value after preparation. Yet embodiment 6 and embodiment 21 make pH value higher than 6.5 because of adding alkaline component, and add citric acid to adjust pH value. The pH value of the solution after preparation in Example 6 was 11.21, and the pH value after adding citric acid ...

Embodiment 23

[0132] Example 23: Preparation of preforms for cosmetic formulations

[0133] Add the raw materials of phase A into a 1000mL glass beaker according to the dosage shown in Table 7, seal it with plastic wrap, and preheat the water bath at 90°C for 30min. Add the phase B raw materials into a 500mL glass beaker according to the dosage shown in Table 7, seal it with plastic wrap, and preheat the water bath at 90°C for 30min.

[0134] After the preheating of phase A is completed, take it out of the water bath, and homogenize it at a speed of 5000 rpm for 2 minutes, until the material is uniform. Thereafter, slowly add phase B to phase A under homogeneous stirring at 5000rpm (1 minute to complete the addition), and keep homogenizing at 5000rpm for 2 minutes after the addition is completed until the material body is uniform. After homogenization, the beaker was sealed with plastic wrap for later use.

[0135] Table 7

[0136]

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Abstract

The invention provides a stabilizing composition containing triethyl citrate and glycine. The composition is an aqueous solution, and the aqueous solution further comprises an active agent capable ofproducing ammonia by hydrolysis, wherein the weight ratio of the active agent to the triethyl citrate is from 1: 1 to 100: 1, and the weight ratio of the active agent to the glycine is from 1: 1 to 10: 1. The invention also relates to a method of stabilizing the aqueous solution containing the active agent capable of producing ammonia by hydrolysis, and relates to application of the stabilizing composition in a skin preparation for external use.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a stable composition comprising triethyl citrate and glycine and a stabilization technology for achieving stabilization in an aqueous solution that is hydrolyzed to generate ammonia. Background technique [0002] Urea is a very useful moisturizing ingredient. It exists in the stratum corneum of the skin and is the main component of the skin's natural moisturizing factor NMF. For the skin, urea has the effect of moisturizing and softening cutin. Urea is one of the natural moisturizing factors in the skin. Its functions of moisturizing, softening the skin and promoting percutaneous penetration have been widely reported in the literature. [0003] The literature "Instrumental and dermatologist evaluation of the effect of glycerin and urea on dry skin in patients with atopic dermatitis" (Dermatology Research and Technology, Lodén M., et al.) reported that after 30 days of using a moisturizi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/37A61K8/42A61K8/44A61Q19/00
CPCA61K8/44A61K8/37A61K8/42A61Q19/00A61K2800/52
Inventor 黄诚贇郭奕光乔小玲
Owner SHANGHAI JAHWA UNITED
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