Application of Rivastigmine in preparation of antiradiation drugs

A technology for anti-radiation and preparation of drugs, which is applied in the field of chemistry and can solve the problems of no reports on the application of rivastigmine

Pending Publication Date: 2021-03-26
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report about the application of rivastigmine in the preparation of anti-radiation drugs

Method used

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  • Application of Rivastigmine in preparation of antiradiation drugs
  • Application of Rivastigmine in preparation of antiradiation drugs
  • Application of Rivastigmine in preparation of antiradiation drugs

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0024] Experimental example 1: Effects of different drugs on irradiated cells or mice

[0025] 1.1 Experimental materials

[0026] 1.1.1 Experimental animals

[0027] SPF grade 4-6 week old C57BL / 6 male mice were purchased from the Institute of Model Animals, Nanjing University. Lgr5-EGFP-ires-CreERT2 (Lgr5-GFP) mice were purchased from Jackson Laboratory, USA. All mice were kept in the SPF grade animal room of Suzhou University Animal Management Center. All drinking water, conventional mouse feed, bedding materials and various experimental supplies that enter the animal room are sterilized by high temperature and high pressure or radiation, undergo strict microbial control, and strictly abide by the rules and regulations of the SPF animal room.

[0028] 1.1.2 Main reagents and consumables

[0029]1) Bioactive Compound Library (790 species: Plinabulin (NPI-2358), Imiquimod, Flavopiridol (Alvocidib), Tamoxifen, CHIR-99021 (CT99021), Celastrol, Ellagic acid, Gatifloxacin, Ba...

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PUM

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Abstract

The invention relates to application of Rivastigmine in preparation of antiradiation drugs and belongs to the technical field of medicines. According to the application of the Rivastigmine in the preparation of the antiradiation drugs, provided by the invention, researches discover that the Rivastigmine can be used for remarkably promoting propagation of Lgr5<+> stem cells subjected to 10Gy irradiation (after 10 days of the 10Gy irradiation, the propagation amount of the Lgr5<+> stem cells cultured in a Rivastigmine-containing culture solution is 14.2 times that of the Lgr5<+> stem cells cultured in a Rivastigmine-free culture solution), the death rate of mice subjected to the 10Gy irradiation can be lowered remarkably (mice free of intraperitoneal injection of the Rivastigmine fully die in 10 days after whole-body irradiation of 10Gy, and the survival rate of mice with intraperitoneal injection of the Rivastigmine is still higher than 40% in 30 days after whole-body irradiation of 10Gy), and the Rivastigmine has a good antiradiation action.

Description

technical field [0001] The invention relates to the application of rivastigmine in the preparation of anti-radiation medicine, which belongs to the field of chemical technology. Background technique [0002] While the widespread application of ionizing radiation has benefited mankind, it also brings many risks. Especially in the application of nuclear energy, it is extremely obvious. There is the Chernobyl nuclear accident far away, and the Fukushima nuclear power plant accident recently. These nuclear leakage accidents have brought serious disasters to human society. [0003] Receiving a certain dose of ionizing radiation can lead to radiation sickness, and receiving 10-50Gy of ionizing radiation for a short period of time can cause acute gastrointestinal syndrome, which is caused by the death of intestinal mucosal stem cells, and nausea, vomiting and diarrhea will occur rapidly, after about a week of incubation period Gastrointestinal symptoms, sepsis, and electrolyte imb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/27A61P39/00
CPCA61K31/27A61P39/00
Inventor 陈秋崔凤梅闫红彬
Owner SUZHOU UNIV
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