A kind of low swelling rate polymer medical hydrogel and preparation method thereof

Abstract

The invention belongs to the technical field of medical hydrogel preparation, and provides a low-swelling polymer medical hydrogel and a preparation method thereof; comprising the following steps: (1) combining carboxylated bacterial cellulose with N,N'-diiso Propylcarbodiimide, 2,2'-dithiodiethanol diacrylate, stir evenly to obtain a uniform viscous solution; (2) add photoinitiator benzoin ethyl ether to the viscous solution, and irradiate it under the ultraviolet high-pressure mercury lamp Radiation polymerization, treatment at 60-70°C for 1-3h after lights out, to obtain a crude gel; (3) standing and washing the crude gel at room temperature, to obtain the low swelling rate polymer medical hydrogel. By acylation and polycondensation of carboxylated bacterial cellulose and N,N'-diisopropylcarbodiimide, and at the same time cross-linking by cross-linking agent 2,2'-dithiodiethanol diacrylate to obtain The hydrogel has a low swelling rate, good biocompatibility, and can be used in small parts of organisms.

Description

A kind of low swelling rate polymer medical hydrogel and preparation method thereof technical field The present invention relates to medical hydrogel preparation technical field, be specifically related to a kind of low swelling rate polymer medical hydrogel and its preparation method. Background technique Polymer hydrogel is a multi-component system composed of polymer three-dimensional network and water, which can be used in macroscopic (volume) in the shape of a huge change. Since hydrogel is a kind of polymer material similar to living tissue, it has good Biocompatibility, does not affect the metabolic process of living organisms, and metabolites can be excreted through the hydrogel, so it can be used as a group Tissue fillers are widely used in tissue engineering scaffolds, while in the controllable delivery of drugs and proteins, as well as in cell and The research on the interaction between biological materials also plays an irreplaceable role. As a kind ...

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Problems solved by technology

Although hydrogel has its unique advantages as a biomaterial, the application of traditional hydrogel in biomedicine is limited due to the inevitable swelling under physiological conditions (Science, 2014, 343: 873)