A photothermal therapy system based on temperature and image dual-mode monitoring and feedback
A technology of photothermal therapy and image monitoring, which is applied in the fields of biomedicine and optics, can solve the problems of low price, inability to use special patients, poor effect, etc., and achieve the effect of controlling distant metastatic tumors
Active Publication Date: 2022-03-08
FUJIAN NORMAL UNIV
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Problems solved by technology
Magnetic resonance imaging (Magnetic Resonance Image, MRI) has clear imaging and good resolution, but the effect is not good for real-time detection, and the price is not cheap, and it may not be available for some special patients; Computed tomography (Computed tomography) Tomography, CT) images have high resolution and low price, but they have side effects on the human body
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Embodiment 1
[0053] In this example, the mouse tumor site is used as the experimental object of this system. In this example, a photothermal therapy system based on temperature and image dual-mode monitoring and feedback includes control feedback module 4, photothermal therapy module 1, temperature Monitoring module 2, OCT image monitoring module 3, CNC sample stage 5;
[0054] In the photothermal therapy module, the semiconductor laser 808nm light source is used as the output light source of the first laser 101, and it is obliquely incident on the mouse tumor site on the sample stage through the first collimator 102 and the optical fiber treatment head 103;
[0055] In the OCT image monitoring module, a 1310nm scanning light source is used as the light beam emitted by the second laser 301. The light beam emitted by the scanning light source passes through the isolator 302 and then enters the fiber coupler 303. The fiber coupler 303 divides the light beam into a reference arm and a sample. ...
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The present invention proposes a photothermal therapy system based on temperature and image dual-mode monitoring and feedback, which can perform precise laser irradiation with a controllable range on the tissue to be treated. The photothermal therapy system includes a control feedback module and an optical Thermal treatment module, temperature monitoring module capable of infrared imaging; the photothermal treatment module irradiates the tissue to be treated with laser to heat it up; the control feedback module obtains infrared thermal imaging of the tissue to be treated through the temperature monitoring module to evaluate the current laser Whether the heating range formed by irradiation is within the preset threshold temperature range of the tissue to be treated, and whether the temperature that the tissue receiving laser irradiation can withstand meets the preset value; Monitoring, and feedback can be combined with temperature monitoring and image monitoring.
Description
technical field [0001] The invention relates to the fields of biomedicine and optical technology, in particular to a photothermal treatment system based on temperature and image dual-mode monitoring and feedback. Background technique [0002] Photothermal therapy is a tumor hyperthermia technique that utilizes heating of local biological tissues to cause coagulation and necrosis of diseased tissue (cancer cell tissue). Its basic process is to introduce a probe with a hole into the tissue or tumor tissue to be treated through percutaneous puncture, and irradiate the tissue with laser light, and the tissue will convert the absorbed light energy into heat energy and diffuse to the surrounding tissue, resulting in a continuous increase in tissue temperature. , to cause thermal coagulation and necrosis of the tumor target tissue, the main process of which is the photothermal response of the tissue. Photothermal treatment of tumors The temperature generated by the photothermal ef...
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IPC IPC(8): A61B18/22A61B90/00A61D7/00A61D1/00
CPCA61B18/22A61B90/361A61B90/37A61D7/00A61D1/00A61B2018/00595A61B2018/00702A61B2018/00714A61B2090/3735
Inventor 吴淑莲李志芳钟兆伟胡志伟吴伟杰李晖
Owner FUJIAN NORMAL UNIV