Photothermal therapy system based on temperature and image dual-mode monitoring and feedback
A photothermal therapy and image monitoring technology, applied in the fields of biomedicine and optics, can solve the problems of low price, poor effect, and inability to use special patients, and achieve the effect of controlling distant metastatic tumors.
Active Publication Date: 2021-04-09
FUJIAN NORMAL UNIV
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Problems solved by technology
Magnetic resonance imaging (Magnetic Resonance Image, MRI) has clear imaging and good resolution, but the effect is not good for real-time detection, and the price is not cheap, and it may not be available for some special patients; Computed tomography (Computed tomography) Tomography, CT) images have high resolution and low price, but they have side effects on the human body
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Embodiment 1
[0053] In this example, the mouse tumor site is used as the experimental object of this system. In this example, a photothermal therapy system based on temperature and image dual-mode monitoring and feedback includes control and processing module 4, photothermal therapy module 1, Temperature monitoring module 2, OCT image monitoring module 3, CNC sample stage 5;
[0054] In the photothermal therapy module, the semiconductor laser 808nm light source is used as the output light source of the first laser 101, and it is obliquely incident on the mouse tumor site on the sample stage 501 through the first collimator 102 and the optical therapy head 103;
[0055] In the OCT image monitoring module, a 1310nm scanning light source is used as the light beam emitted by the second laser 301. The light beam emitted by the scanning light source passes through the isolator 302 and then enters the fiber coupler 303. The fiber coupler 303 divides the light beam into a reference arm and a sample...
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The invention provides a photothermal therapy system based on temperature and image dual-mode monitoring and feedback. The system can perform range-controllable accurate laser irradiation on a to-be-treated tissue. The photothermal therapy system comprises a control feedback module, a photothermal therapy module connected with the control feedback module, and a temperature monitoring module capable of performing infrared imaging, wherein the photothermal therapy module irradiates the to-be-treated tissue with laser to heat the to-be-treated tissue; and the control feedback module acquires infrared thermal imaging of the to-be-treated tissue through the temperature monitoring module to evaluate whether a heating range formed by current laser irradiation is within a preset threshold temperature range of the to-be-treated tissue and whether the temperature that the tissue receiving the laser irradiation can bear meets a preset value. The system provided by the invention can monitor important parameters in a photothermal therapy process, and can perform feedback in combination with temperature monitoring and image monitoring.
Description
technical field [0001] The invention relates to the fields of biomedicine and optical technology, in particular to a photothermal treatment system based on temperature and image dual-mode monitoring and feedback. Background technique [0002] Photothermal therapy is a tumor hyperthermia technique that utilizes heating of local biological tissues to cause coagulation and necrosis of diseased tissue (cancer cell tissue). Its basic process is to introduce a probe with a hole into the tissue or tumor tissue to be treated through percutaneous puncture, and irradiate the tissue with laser light, and the tissue will convert the absorbed light energy into heat energy and diffuse to the surrounding tissue, resulting in a continuous increase in tissue temperature. , to cause thermal coagulation and necrosis of the tumor target tissue, the main process of which is the photothermal response of the tissue. Photothermal treatment of tumors The temperature generated by the photothermal ef...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61B18/22A61B90/00A61D7/00A61D1/00
CPCA61B18/22A61B90/361A61B90/37A61D7/00A61D1/00A61B2018/00595A61B2018/00702A61B2018/00714A61B2090/3735
Inventor 吴淑莲李志芳钟兆伟胡志伟吴伟杰李晖
Owner FUJIAN NORMAL UNIV