Application of ellagic acid and metabolites thereof as natural inhibitors to preparation of anti-pyroptosis medicine
A technology of ellagic acid and inhibitors, which is applied in the application field of preparing anti-pyroptotic drugs, and can solve problems such as the lack of natural drugs
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Embodiment 1
[0043] Example 1 Application of ellagic acid and its metabolites as natural inhibitors in the protection of pancreatic cell inflammation
[0044] 1.1 Experimental animals
[0045] 10-week-old c57BL / 6 male mice of SPF grade, weighing 24±2 g, were purchased from the Animal Center of Xinjiang Medical University (animal license number: SYXK (new) 2016-0002).
[0046] 1.2 Experimental materials
[0047] Ordinary feed was purchased from the Animal Experiment Center of Xinjiang Medical University; high-fat feed was purchased from Nantong Trofe Feed Co., Ltd.; STZ was purchased from Sigma Biological Co., Ltd.; EA was purchased from Shanghai Macklin Biochemical Technology Co., Ltd. (purity ≥ 98%); UroA Purchased from Shanghai Zhenzhun Biological Co., Ltd. (purity ≥ 98%); Glucagon (GC) ELISA detection kit, C-reactive protein (CRP) ELISA detection kit, both purchased from Shanghai Sibobestbio Biotechnology Co., Ltd.; NLRP3 , cleaved-caspase3 (cleaved-caspase3), IL-1β antibody, caspase1...
Embodiment 2
[0083] Example 2 Application of ellagic acid and its metabolites as natural inhibitors in the protection of liver cell inflammation
[0084] 1. Materials and methods
[0085] Experimental animals, experimental materials, animal model preparation, animal administration, hematoxylin-eosin staining to observe the pathological structure of mouse liver tissue refer to 1.1, 1.2, 1.3, 1.4, 1.6 of Example 1, respectively.
[0086] After the animal administration experiment, the mouse liver tissue was taken, and the appearance was photographed, see Figure 4 , Figure 4 a-d are Normal group, Model group, EA group and UroA group respectively. The results showed that the livers of the mice in the Normal group were fresh and pink; the mice in the Model group showed white ischemia and high fat content; the liver color of the mice in the EA group was significantly improved and turned pink; the liver appearance of the mice in the UroA group was significantly improved and turned pink. colo...
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