Preparation method of 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine

Abstract

The invention discloses a preparation method of 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine, which comprises the following steps: by using ethylamine and cyanamide as initial raw materials, generating N-ethylguanidine sulfate under the action of concentrated sulfuric acid, reacting with 2-n-butyl ethyl acetoacetate under the action of sodium hydroxide for 1-4 hours, and carrying out after-treatment to obtain 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine. According to the method, cheap and easily available ethylamine and cyanamide are used as initial raw materials, the method is green and environment-friendly, isomers are separated by using a preparative chromatography technology, the yield and purity of the product are relatively high, and the method has a wide industrial application prospect.

Description

technical field

[0001] The invention relates to a preparation method of 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine, which belongs to the technical field of organic synthesis chemistry. Background technique

[0002] 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine, English common name ethirimol, structural formula is: 5-n-Butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine is a systemic pyrimidine fungicide used to control powdery mildew in crops such as apples, greenhouse roses and strawberries, the color is White solid powder, precisely because of the excellent characteristics of 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine, it has been widely used in the field of medicine and polymer fields. The annual market demand for 5-n-butyl-2-ethylamino-4-hydroxy-6-methylpyrimidine is far greater than the supply, and the synthesis of 5-n-butyl-2-ethylamino-4-hydroxy The new method of -6-methylpyrimidine has been a research hotspot for chemists. The production techn...

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