Drug intervention target for tumor-related secondary lymphedema and application thereof

A technology related to lymphedema and tumors, applied in the field of biomedicine, can solve problems that affect the quality of life of patients, heavy physical and psychological burdens, and achieve the effect of alleviating adipose tissue fibrosis
CN112691194APending Publication Date: 2021-04-23PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
Publication Date
2021-04-23

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Abstract

The invention discloses a drug intervention target for tumor-related secondary lymphedema. The target is a CLEC3B gene and an encoding protein thereof. The expression of the gene provided by the invention in adipose-derived stem cells derived from tumor-related secondary lymphedema patients is significantly up-regulated. The siRNA-mediated CLEC3B gene knock-down can significantly down-regulate fibrosis and TGF-beta signal pathway related gene expression, so that lymphedema adipose tissue fibrosis can be effectively relieved. On this basis, drugs including siRNA designed for the target can be used for treating and relieving lymphedema. The invention provides the new drug target for the treatment of lymphedema.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and specifically relates to a drug intervention target for tumor-associated secondary lymphedema and its application in alleviating pathological fibrosis of adipose tissue. Background technique

[0002] Lymphedema generally refers to the pathological phenomenon in which interstitial fluid accumulates in tissues caused by obstruction or dysfunction of lymphatic return in certain parts of the body. Secondary lymphedema is the most common form and occurs after dissection of tumor lymph nodes, so-called tumor-associated secondary lymphedema. It has been reported that up to 20% of breast cancer patients develop secondary lymphedema after treatment. Lymphedema generally manifests as progressive swelling of subcutaneous adipose tissue of limbs, chronic inflammatory response of adipose tissue, pathological fibrosis of adipose tissue and excessive fat deposition and other pathological processes. Lymphedema of...

Claims

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