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Preparation method of high-density NMN

A high-density, bulk density technology, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of low bulk density and poor fluidity, and achieve the effect of improving product yield and increasing fluidity

Pending Publication Date: 2021-04-23
EFFEPHARM (SHANGHAI) CO LTD
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AI Technical Summary

Problems solved by technology

For this reason, many companies in the world have launched anti-aging products based on NMN. However, most of the NMN produced by the traditional process is based on the freeze-drying method, so that the bulk density of the product is very low, basically less than 0.2g / mL, and the flow sex is also relatively poor
It has brought great challenges to traditional finished product processing techniques such as capsule canning and tablet pressing

Method used

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Examples

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preparation example Construction

[0018] see Figure 1-2 , the present invention provides a technical solution: a preparation method of high-density NMN, the specific steps are as follows:

[0019] Step 1: After continuously adding a poor solvent to the aqueous solution of NMN, a water-containing NMN oily layer is formed;

[0020] Step 2: Then repeatedly beat the oil layer with a poor solvent to dilute the water content in the oil layer and slowly transform it into a white powder;

[0021] Step 3: After filtering and drying, the particle shaker is crushed and passed through a 40-80 mesh sieve, which is NMN with high bulk density.

[0022] The NMN aqueous oil layer in the step one has a water content of 5-20%, and the poor solvent in the step one is any one of ethanol, methanol, Virahol, acetonitrile and DMF, and the The consumption of poor solvent is 5-10 times of volume ratio of aqueous solution, and the consumption of the water used in described step 1 is 2-10 times of solid weight, and the beating times o...

Embodiment 1

[0026] Weigh 100g of low-density NMN finished product and dissolve it in 500mL of water to obtain a colorless and transparent NMN aqueous solution. Slowly add 2L of absolute ethanol to the aqueous solution. With the increase of ethanol, the solution first becomes an emulsion, and finally separates into two phases of oil and water. The upper layer is the ethanol water phase, and the lower layer is the oil phase formed by NMN and water. After the oil phase was separated through a separatory funnel, 1 L of absolute ethanol was added to the oil phase, and stirred for 1 hour to obtain a colorless viscous liquid. After filtration, 1 L of ethanol was added to the solid layer, stirred for one hour, and a white sandy solid was obtained by filtration. The white solid was lyophilized and weighed to obtain 98 g of the product. After the solid passes through a 60-mesh sieve, the bulk density is measured after detection: the bulk density is 0.52g / mL, and the tap density is 0.71g / mL.

[0...

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Abstract

The invention discloses a preparation method of high-density NMN, which comprises the following steps: dissolving NMN with pure water, and adding a poor solvent such as ethanol to form an oily product layer and an ethanol-water mixed solution layer; and after separating out the oil layer, adding ethanol continuously, extracting water in the oil layer repeatedly for multiple times to obtain a white solid, carrying out centrifugation, drying and smashing to masure an ultrahigh-bulk-density NMN product with the bulk density larger than 0.5 g / mL and the compact density larger than 0.7 g / mL. The characteristic that NMN is poor in solubility in a conventional solvent is utilized, the NMN is dissolved in water firstly, and then the poor solvent is added, so that the NMN and the water are combined into a tight oily matter; then the water-soluble poor solvent is added continuously to reduce the water content in the oily matter so as to solidify the NMN product; and finally, the high bulk density NMN product wis obtained after filtering and drying.

Description

technical field [0001] The invention relates to the field of dietary supplements, in particular to a method for preparing high-density NMN. Background technique [0002] The chemical name of NMN is β-Nicotinamide Mononucleotide (β-Nicotinamide Mononucleotide). Nicotinamide mononucleotide (NMN) plays an important role in the energy generation of human cells. It participates in the synthesis of NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion) in cells. NMN and NAD are produced in the human body, but with age, their content in various organs will decrease. In recent years, many research institutions have published articles in top international journals to prove that NMN does have many effects. Especially the elderly population over 60 years old, whose NAD content in the body is significantly lower than that of young people. For this reason, many companies in the world have launched anti-aging products based on NMN. However, most of th...

Claims

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Application Information

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IPC IPC(8): C07H1/06C07H19/048
CPCC07H1/06C07H19/048
Inventor 余建军徐钦源
Owner EFFEPHARM (SHANGHAI) CO LTD
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