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Caffeine microcapsule, preparation method thereof and compound paracetamol preparation

A technology of caffeine and microcapsules, which is applied in the fields of preparation, caffeine microcapsules and compound paracetamol preparations

Active Publication Date: 2021-04-30
吉林省吴太感康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, about 3 hours after taking the medicine, the concentration of chlorpheniramine maleate in the blood reaches the peak value, and the adverse reactions of fatigue and drowsiness begin to aggravate. At this time, the peak value of the blood concentration of caffeine has been missed, resulting in that the caffeine cannot be absorbed very quickly. It plays a good role in stimulating the central nervous system, and the adverse reactions of drugs and drowsiness are more obvious

Method used

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  • Caffeine microcapsule, preparation method thereof and compound paracetamol preparation
  • Caffeine microcapsule, preparation method thereof and compound paracetamol preparation
  • Caffeine microcapsule, preparation method thereof and compound paracetamol preparation

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Effect test

Embodiment 1

[0039] The preparation of embodiment 1 microcapsule of the present invention

[0040] Heat water to 80°C, add wall material octenyl succinic esterified starch to dissolve, cool to room temperature, the mass ratio of wall material to water is 5:10, and obtain the first wall material aqueous solution;

[0041] Heat water to 80°C, add wall material to dissolve carboxymethyl cellulose, cool to room temperature, the mass ratio of wall material to water is 5:10, and obtain the second wall material aqueous solution;

[0042] The core material (caffeine) is mixed with ethanol according to the mass ratio of 5:25 to obtain the ethanol solution of the core material;

[0043]The mass ratio of caffeine to the first wall material and the second wall material is 5:1:1;

[0044] Add the ethanol solution of the core material to the aqueous solution of the first wall material to form a suspension.

[0045] Homogenize the suspension after dispersion, the pressure of the first homogenization is...

Embodiment 2

[0047] The preparation of embodiment 2 microcapsules of the present invention

[0048] Heat water to 80°C, add wall material octenyl succinic esterified starch to dissolve, and cool to room temperature, wherein the mass ratio of wall material to water is 5:10 to obtain the first wall material aqueous solution;

[0049] Heat water to 80°C, add wall material to dissolve carboxymethyl cellulose, cool to room temperature, the mass ratio of wall material to water is 1:10, and obtain the second wall material aqueous solution;

[0050] The core material and ethanol are mixed according to the mass ratio of 5:60 to obtain the ethanol solution of the core material;

[0051] The mass ratio of caffeine to the first wall material and the second wall material is 5:5:5;

[0052] Add the ethanol solution of the core material to the aqueous solution of the first wall material to form a suspension.

[0053] Homogenize the suspension after dispersion, the pressure of the first homogenization i...

Embodiment 3

[0055] The preparation of embodiment 3 microcapsules of the present invention

[0056] Heat water to 80°C, add wall material octenyl succinic esterified starch to dissolve, cool to room temperature, the mass ratio of wall material to water is 1:10, and obtain the first wall material aqueous solution;

[0057] Heat water to 80°C, add wall material to dissolve carboxymethyl cellulose, cool to room temperature, the mass ratio of wall material to water is 5:10, and obtain the second wall material aqueous solution;

[0058] The core material (caffeine) is mixed with ethanol according to the mass ratio of 25:60 to obtain the ethanol solution of the core material;

[0059] The mass ratio of caffeine to the first wall material and the second wall material is 25:1:1;

[0060] Add the ethanol solution of the core material to the aqueous solution of the first wall material to form a suspension.

[0061] Homogenize the suspension after dispersion, the pressure of the first homogenizatio...

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Abstract

The invention relates to the technical field of pharmaceutical preparations, in particular to a caffeine microcapsule, a preparation method thereof and a compound paracetamol and amantadine hydrochloride preparation of the caffeine microcapsule. The caffeine microcapsule comprises a core material, a first wall material wrapping the core material and a second wall material wrapping the first wall material, wherein the core material is caffeine, the first wall material is octenyl succinic acid esterified starch, and the second wall material is carboxymethyl cellulose. According to the invention, caffeine is microencapsulated by using a proper wall material, and the absorption of caffeine in a human body is delayed, so that the difference between the blood concentration peak reaching time of caffeine and the blood concentration peak reaching time of chlorpheniramine maleate is shortened to the greatest extent, and the sleepiness caused by chlorpheniramine maleate can be better relieved. In addition, the caffeine is strong in bitter taste, and direct addition of the caffeine in the medicine can cause bitter taste and poor taste of the medicine. According to the caffeine microcapsule provided by the invention, due to the addition of the modified starch, the caffeine raw material is wrapped to a certain extent, so that the bitter taste of the medicine is relieved, and the taking feeling of a patient is better.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a caffeine microcapsule, a preparation method thereof and a compound paracetamol preparation. Background technique [0002] Anti-cold medicines are commonly used medicines in people's daily life. Most of the anti-cold medicines on the market are compound preparations, which are suitable for various colds, and have quick onset and long efficacy. Most of them contain ingredients of antihistamines chlorpheniramine maleate or diphenhydramine, which can relieve allergic symptoms such as sneezing, runny nose, and watery eyes in cold patients, but because they can pass through the blood-brain barrier The central nervous system plays an inhibitory role, so this type of anti-cold medicine all shows side effects of drowsiness and drowsiness after taking it, which will cause inconvenience to the life and work of the patient after taking it. [0003] Caffeine is a xanthi...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/36A61K47/38A61K31/522A61K31/4402A61K35/413A61P11/00A61K31/167A61K31/13
CPCA61K9/5036A61K9/5042A61K31/522A61K31/4402A61K31/167A61K31/13A61K35/413A61P11/00A61K2300/00
Inventor 邢福涛
Owner 吉林省吴太感康药业有限公司
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