Crystal form of benzimidazole derivative and preparation method thereof

Abstract

The invention relates to a crystal form of a benzimidazole derivative and a preparation method thereof. Specifically, the disclosure relates to a crystal form A of a compound shown in a formula I and a preparation method thereof. The crystal form A of the compound shown in the formula I has the advantages in the aspects of stability and hygroscopicity, is more suitable for medicine development, can meet the medicinal requirements of production, transportation and storage, and is stable in production process, repeatable and controllable and suitable for industrial production.

Description

Technical field[0001]The present disclosure belongs to the field of pharmaceutical chemistry, which relates to a crystalline form of a benzimidazole derivative, in particular, a crystalline form, and a method of preparation thereof.Background technique[0002]Nuclear Resistance is a ligand-regulated transcription factor, which regulates development, immunity and cellular metabolism, one of the main drug target categories of human diseases. The alcohol-associated orphan receptor γ (RORγ) protein is a member of the NR1 subfamily of the nuclear receptor, and has a typical nuclear receptor domain structure, a DNA binding domain, a ligand binding domain, a hinge domain. And activation function 2 domain composition (Benoit G, et al, Pharmacology Reviews, 58 (4): 798-836, 2006; ZHANG, Y., ET Al., Acta Pharmacogica Sinica, 36: 71-87, 2015). In contrast to most other nuclear receptors bind to the dimer, RORγ identifies and combined as a monomer. It is combined with a particular DNA sequence, t...

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Problems solved by technology

Generally speaking, amorphous drug products have no regular crystal structure and often have other defects, such as poor product stability, fine crystallization, difficult filtration, easy agglomeration, poor fluidity, etc.

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