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Composition for preventing or treating liver diseases

A composition and group technology, applied in the direction of drug combination, boron compound active ingredients, hydroxyl compound active ingredients, etc., can solve problems such as the lack of joint use of liver disease treatment technology, imperfect effect of liver fibrosis, etc., to achieve good liver disease prevention or Therapeutic effect, prevention or treatment of liver disease, effect of reduction of liver damage

Pending Publication Date: 2021-05-07
艾斯生物医药株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are a lot of researches and prior art related reports on the treatment of liver diseases using the DPP-4 inhibitor, the administration for the purpose of treating the above-mentioned diseases is limited due to the incomplete effect of improving liver fibrosis, etc. Yes, there is no report on liver disease treatment technology using these drugs in combination

Method used

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  • Composition for preventing or treating liver diseases
  • Composition for preventing or treating liver diseases
  • Composition for preventing or treating liver diseases

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0078]

[0079] 1. Experimental materials

[0080] AML12 cells (CRL-2254) were purchased from the American Type Culture Collection (ATCC). Colchicine (C9754), sodium palmitate (Sodium palmitate; P9767), superoxide anion fluorescent probe (dihydroethidium, DHE; D7008) were purchased from Sigma-Aldrich Company. Alogliptin (brand name: Nesina) was purchased from Takeda Pharmaceutical, South Korea, igagliptin (brand name: Suganon) was purchased from East Asia ST Company, gemagliptin (brand name: Zemiglo) was purchased from LG Life Sciences, and Gliptin (brand name: Onglyza) was purchased from Bristol-Myers Squibb, sitagliptin (brand name: Januvia) was purchased from Merck, and treglitin (brand name: Ziten) was purchased from Glenmark Pharmaceuticals. Vildagliptin (brand name: Galvus) was purchased from Novartis Pharmaceuticals.

[0081] 2. Cell Culture and Drug Treatment

[0082] Mouse hepatocyte-AML12 cells were treated at 37°C under 95% air and 5% CO2 environment, containin...

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Abstract

The present invention provides a composition for preventing or treating a liver disease, and more particularly, to a pharmaceutical composition for preventing or treating a liver disease, which contains colchicine and a DPP-4 (dipetidylpetidase-4) inhibitor as active ingredients. The pharmaceutical composition according to the present invention can significantly reduce liver injuries such as fibrosis, fat accumulation, inflammation and the like in liver cells or liver tissues by combined administration of colchicine and a DPP-4 inhibitor which are commonly used for treating other diseases, and can more effectively prevent or treat liver diseases by using the same.

Description

technical field [0001] The present invention relates to a composition for preventing or treating liver diseases, in particular to a composition containing colchicine and dipeptidyl peptidase-4 (dipeptidyl peptidase-4, DPP-4) inhibitors as active ingredients A pharmaceutical composition for preventing or treating liver diseases. Background technique [0002] The liver (liver) is a biological organ that plays a central role in the metabolism of substances from the outside and in the body and continuously undergoes enzyme reactions and energy metabolism. In fact, hepatitis, liver cirrhosis, and liver cancer currently account for the highest proportion of chronic diseases in Korea, as well as circulatory system diseases, and also account for the largest number of causes of death due to diseases. A large proportion. Especially compared with developed countries, the number of people who drink alcohol is relatively large, and alcoholism is a major cause of liver damage, so attent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61K45/06A61P1/16A61P29/00
CPCA61K31/165A61K45/06A61P1/16A61P29/00A61K31/4985A61K31/519A61K31/513A61K31/69A61K31/495A61K31/403A61K31/4375A61K31/045A61K31/51A61K31/375A61K31/355A61K2300/00A61K31/7088A61P3/06A61K31/197A61K31/40A61K31/4162A61K31/4415A61K31/455A61K31/522A61K31/525A61K31/575A61K31/593A61K31/714A61K38/06
Inventor 车旺祚尹胄晧咸宣娥
Owner 艾斯生物医药株式会社