Myocardial infarction differential expression gene and application thereof
A technology for myocardial infarction and gene expression, applied in the field of biomedicine, can solve the problems of lack of molecular targets for effective diagnosis, prevention and treatment of myocardial infarction
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[0043] Example 1 Screening for Differentially Expressed Genes in Acute Myocardial Infarction
[0044] 1. Data source
[0045] Download the acute myocardial infarction (AIM) dataset GSE66360 from the GEO database, and the sample size is control: AIM=50:49.
[0046] 2. Differential expression analysis
[0047] The "limma" package in R software was used for differential expression analysis, and the screening standard for differential genes was adj.Pvalue<0.05.
[0048] 3. Experimental results
[0049] Analysis results show that the biomarker TEX30 involved in the present invention is up-regulated in samples from patients with acute myocardial infarction, and ZNF420 is down-regulated in samples from patients with acute myocardial infarction, as shown in Table 1 and figure 1 shown.
[0050] Table 1. Differential expression of TEX30 and ZNF420
[0051] Gene AveExpr t P.Value TEX30 7.61 4.28 0.00 ZNF420 7.26 -5.69 0.00
[0052] Example 2 Diagn...
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