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Myocardial infarction differential expression gene and application thereof

A technology for myocardial infarction and gene expression, applied in the field of biomedicine, can solve the problems of lack of molecular targets for effective diagnosis, prevention and treatment of myocardial infarction

Pending Publication Date: 2021-05-07
THE SECOND AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there have been in-depth studies on the regulatory targets related to myocardial infarction, such as inhibitory growth factor ligands, various receptors (platelet-derived growth factor receptor, vascular endothelial growth factor receptor, epidermal growth factor receptor) and various enzymes However, molecular targets for effective diagnosis, prevention and treatment of myocardial infarction are still lacking, so it is of great significance to search for molecular markers of myocardial infarction

Method used

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  • Myocardial infarction differential expression gene and application thereof
  • Myocardial infarction differential expression gene and application thereof
  • Myocardial infarction differential expression gene and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Screening for Differentially Expressed Genes in Acute Myocardial Infarction

[0044] 1. Data source

[0045] Download the acute myocardial infarction (AIM) dataset GSE66360 from the GEO database, and the sample size is control: AIM=50:49.

[0046] 2. Differential expression analysis

[0047] The "limma" package in R software was used for differential expression analysis, and the screening standard for differential genes was adj.Pvalue<0.05.

[0048] 3. Experimental results

[0049] Analysis results show that the biomarker TEX30 involved in the present invention is up-regulated in samples from patients with acute myocardial infarction, and ZNF420 is down-regulated in samples from patients with acute myocardial infarction, as shown in Table 1 and figure 1 shown.

[0050] Table 1. Differential expression of TEX30 and ZNF420

[0051] Gene AveExpr t P.Value TEX30 7.61 4.28 0.00 ZNF420 7.26 -5.69 0.00

[0052] Example 2 Diagn...

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Abstract

The invention discloses a myocardial infarction differential expression gene and application thereof. A biomarker comprises TEX30 and / or ZNF420. Compared with normal people, TEX30 and ZNF420 show significant difference in myocardial infarction patients, and an ROC curve shows that the TEX30 and ZNF420 have a relatively high AUC value, which prompts that TEX30 and / or ZNF420 can be applied to myocardial infarction diagnosis. The invention provides a product for diagnosing myocardial infarction. The invention also provides a pharmaceutical composition for treating myocardial infarction.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to myocardial infarction differentially expressed genes and applications thereof. Background technique [0002] According to the latest epidemiological statistics, cardiovascular disease is currently the leading cause of death among residents in my country, and its death toll accounts for more than 40% of the total number of deaths from diseases among residents. Among them, the incidence of myocardial infarction has shown a rapid upward trend in recent years. One of the diseases of health. Myocardial necrosis after myocardial infarction leads to a series of clinical events such as heart failure, myocardial rupture or arrhythmia. To prevent myocardial necrosis, myocardial ischemia should be treated early, such as fibrinolytic therapy, coronary artery bypass grafting, PCU, etc. will significantly improve the prognosis. Despite advances in cardiovascular disease research and significant imp...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883G01N33/68A61K45/00A61P9/10
CPCC12Q1/6883G01N33/6893A61K45/00A61P9/10C12Q2600/158G01N2800/324G01N2333/47
Inventor 赵强李正美赵洋康玲江科李元民姜广运
Owner THE SECOND AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIV
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