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Freeze-dried quick-release tablet of traditional Chinese medicine prescription for treating halitosis and preparation method thereof

A technology for immediate-release tablets and traditional Chinese medicines, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as poor taste, foreign body sensation, side effects, etc., and achieves convenient portability, safe use, and reasonable compatibility. Effect

Active Publication Date: 2022-04-08
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Various existing preparations, such as liquid preparations, solid preparations, semi-solid preparations, etc., have a certain effect on alleviating halitosis, but the preparation of liquid preparations can only temporarily suppress breath, and cannot keep the oral cavity for a long enough effective antibacterial time. And it is inconvenient to carry and use; the drug is released slowly after being made into a solid preparation, and it cannot take effect quickly, and there is a certain foreign body sensation in the oral cavity, and it is mostly prepared by western medicine, which is prone to drug resistance, poor taste, and certain side effects ; and semi-solid preparations such as toothpaste can clean the oral cavity to a certain extent, but the antibacterial effect is not obvious, and it cannot effectively remove bad breath

Method used

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  • Freeze-dried quick-release tablet of traditional Chinese medicine prescription for treating halitosis and preparation method thereof
  • Freeze-dried quick-release tablet of traditional Chinese medicine prescription for treating halitosis and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] This example provides a freeze-dried quick-release tablet of traditional Chinese medicine for the treatment of halitosis. The freeze-dried quick-release tablet uses the traditional Chinese medicine for the treatment of halitosis as a raw material, which is extracted by ultrasound and mixed with medicinal excipients before being reused. Oral immediate-release tablet prepared by freeze-drying process, wherein, by weight, the traditional Chinese medicine prescription includes: 15 parts of Cortex Moutan, 5 parts of Duanxueliu, 6 parts of Rhizoma Chuanxiong, 12 parts of Licorice, 15 parts of Clove, 6 parts of Orange Peel 12 parts, 12 parts of tea leaves, 6 parts of Galla chinensis, and 4 parts of white chrysanthemum; the pharmaceutical excipients include fillers, water-soluble binders, suspending agents, disintegrants, pH regulators, preservatives and correctives. In the embodiment, the pharmaceutical excipients include: 20 parts of mannitol, 5 parts of gelatin, 20 parts of x...

Embodiment 2

[0037] This example provides a freeze-dried quick-release tablet of traditional Chinese medicine for the treatment of halitosis. The freeze-dried quick-release tablet uses the traditional Chinese medicine for the treatment of halitosis as a raw material, which is extracted by ultrasound and mixed with medicinal excipients before being reused. Oral immediate-release tablet prepared by freeze-drying process, wherein, by weight, the traditional Chinese medicine prescription includes: 20 parts of Cortex Moutan, 8 parts of Duanxueliu, 10 parts of Rhizoma Chuanxiong, 8 parts of Licorice, 10 parts of Clove, 2 parts of Orange Peel 18 parts, 18 parts of tea leaves, 10 parts of Galla chinensis, 8 parts of white chrysanthemum; the pharmaceutical excipients include fillers, water-soluble binders, suspending agents, disintegrants, pH regulators, preservatives and flavoring agents. In the embodiment, the pharmaceutical excipients include: 20 parts of mannitol, 5 parts of gelatin, 20 parts of...

Embodiment 3

[0044] This example provides a freeze-dried quick-release tablet of traditional Chinese medicine for the treatment of halitosis. The freeze-dried quick-release tablet uses the traditional Chinese medicine for the treatment of halitosis as a raw material, which is extracted by ultrasound and mixed with medicinal excipients before being reused. Oral immediate-release tablet prepared by freeze-drying process, wherein, by weight, the traditional Chinese medicine prescription includes: 18 parts of Cortex Moutan, 6 parts of Duanxueliu, 8 parts of Rhizoma Chuanxiong, 10 parts of Licorice, 12 parts of Clove, 5 parts of Orange Peel 15 parts, 15 parts of tea leaves, 8 parts of Galla chinensis, 6 parts of white chrysanthemums; the pharmaceutical excipients include fillers, water-soluble binders, suspending agents, disintegrants, pH regulators, preservatives and correctives. In the embodiment, the pharmaceutical excipients include: 20 parts of mannitol, 5 parts of gelatin, 20 parts of xant...

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Abstract

The invention discloses a freeze-dried quick-release tablet of a traditional Chinese medicine prescription for treating halitosis and a preparation method thereof, and relates to the technical field of traditional Chinese medicine. Oral immediate-release tablets are prepared by mixing medicinal excipients and using a freeze-drying process, wherein the traditional Chinese medicine prescription includes: Cortex Moutan, Duanxueliu, Ligusticum Chuanxiong, Licorice, Clove, Orange Peel, Tea, Galla Chrysanthemum and White Chrysanthemum , the preparation method is the combination of ultrasonic-assisted extraction and freeze-drying technology. Compared with the prior art, the pure traditional Chinese medicine component formula adopted in the present invention not only has the effect of sterilization and deodorization, but also has reasonable compatibility of each component, is safe to use, and the tablet is easy to carry. It needs water, dissolves quickly in saliva, absorbs quickly through the oral mucosa, achieves the purpose of quick release, and does not cause foreign body sensation in the oral cavity.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a freeze-dried quick-release tablet of a traditional Chinese medicine prescription for treating halitosis and a preparation method thereof. Background technique [0002] Bad breath refers to the abnormal smell that the mouth sends out when breathing, which is a bad state. According to statistics, 80% to 90% of bad breath comes from the oral cavity. It is mainly caused by oral microorganisms producing volatile sulfides and other odorous substances (such as indoles and diamines) through spoilage and digestion of retained substances in the oral cavity. Untreated dental caries, poor restorations, abnormal anatomy, gingivitis, periodontitis, and oral mucosal disease in the oral cavity can all cause bad breath. Among them, dental caries and periodontal disease are the most common related diseases. In deep carious cavities and under the overhang of bad restorati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/82A61P1/02A61P31/02A61K35/64
CPCA61K36/71A61K36/65A61K36/53A61K36/236A61K36/484A61K36/61A61K36/752A61K36/82A61K35/64A61K36/287A61K9/2095A61K9/006A61K9/2063A61P1/02A61P31/02A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 何宁单爽郑峙澐桂双英
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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