Integrated device for preparing, separating and purifying silyl enol ether

Abstract

The invention discloses an integrated device for preparing, separating and purifying silyl enol ether. The integrated device comprises a reaction unit, a purification unit and an absorption unit which are connected in sequence, wherein the reaction unit comprises a reactor, and the left upper end face, the top end face and the right upper end face of the reactor are provided with a reactor left opening, a reactor center opening and a reactor right opening; the purification unit comprises a distiller; a distiller left opening, a distiller center opening and a distiller right opening are respectively formed in the left upper end surface, the top end surface and the right upper end surface of the distiller; the absorption unit comprises an absorber, and the upper left end face, the top end face and the upper right end face of the absorber are provided with an absorber left opening, an absorber center opening and an absorber right opening respectively. Through the device, preparation of silyl enol ether, treatment of trimethylchlorosilane, distillation and purification can be realized, a high-purity silyl enol ether product is obtained, the operation is simple and convenient, residual acidic substances in a reaction system can be completely treated, and the device is green and environment-friendly.

Description

technical field [0001] The invention relates to the field of organic experimental devices for preparing enol silyl ethers, in particular to an integrated device for the preparation, separation and purification of enol silyl ethers. Background technique [0002] Since the Mukaiyama group (Mukaiyama T, Narasaka K, Banno K.NEW ALDOL TYPEREACTION[J].Chemistry Letters,1973,2(9):1011-1014.) used enol silyl ethers to participate in the Aldol reaction in 1973, enol silicon Ethers have long been favored by organic chemists due to their unique structures and properties. In 2009, Feng Xiaoming's group (Chemistry-A European Journal, 2017, 23, 1779) used enol silyl ethers to react with nitrogen compounds to construct chiral 1,4-diphenyl-2-hydroxy-1,4-di Butanone compounds (Zheng K, Liu X, Zhao J, et al.Highlyenantioselective aza-ene-type reaction catalyzed by chiral N,N'-dioxide-nickel(II)complex.[J].Chemical Communications,2010,46 (21):3771-3.); In 2019, Wang Zhiyong's research group ...

AI Technical Summary

Problems solved by technology

The experiment needs to be disassembled many times, and the operation is complicated and air pollution will inevitably be caused to endanger the health of the experimenters; every step of the operation needs to be replaced with a new container to hold the reaction system, which will cause the loss of the enol silyl ether product during the operation

At present, there is no integrated experimental device aimed at solving the problems of cumbersome equipment, pollution and toxicity in the preparation process of enol siloxane

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