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Novel functional polymer material capable of enhancing photodynamic antibacterial effect as well as preparation method and application of novel functional polymer material

A technology of reaction and photosensitizer, applied in the field of new functional polymer materials and its preparation, can solve the problems of mammalian cytotoxicity, reduced treatment efficiency of Gram-negative bacteria, adverse tissue reactions, etc.

Active Publication Date: 2021-05-18
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the regular structure of the outer cell layer of Gram-negative bacteria, they show very strong resistance to various photosensitizers, and it is difficult for photosensitizers to penetrate the outer layer of the cell structure and enter the interior of the cell, making PACT resistant to Gram-negative bacteria. The treatment efficiency of bacteria is greatly reduced
According to the characteristics of such bacteria, researchers will use outer membrane disrupting agents in the process of bacterial PACT, which are often used to increase the sensitivity of bacteria to PACT, but these agents may be potentially toxic to mammalian cells or cause tissue damage. Adverse reactions

Method used

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  • Novel functional polymer material capable of enhancing photodynamic antibacterial effect as well as preparation method and application of novel functional polymer material
  • Novel functional polymer material capable of enhancing photodynamic antibacterial effect as well as preparation method and application of novel functional polymer material
  • Novel functional polymer material capable of enhancing photodynamic antibacterial effect as well as preparation method and application of novel functional polymer material

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Experimental program
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Effect test

Embodiment 1

[0033] (1) Preparation of n-octanoyl modified branched polyethyleneimine

[0034] In a three-necked flask, dissolve 500 mg of branched polyethyleneimine (weight average molecular weight 10Kda) and 278 μL of triethylamine in 15 mL of anhydrous N, N dimethylformamide, stir to completely dissolve the above-mentioned substances, and then vigorously stir 5 mL of anhydrous N,N dimethylformamide solution dissolved with different amounts of octanoyl chloride (OC) was slowly added dropwise. After the dropwise addition, react at 70°C for 24h. After the reaction, the reaction mixture was transferred to a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed in 1 L of ultrapure water for 48 hours to remove organic solvents and small molecular impurities produced by the reaction. During dialysis, the ultrapure water was changed every 6 hours. After the dialysis, the retentate in the dialysis bag was removed, and after being frozen, the retentate was freeze-dried, and the ...

Embodiment 2

[0041] 1, a kind of preparation method of the branched polyethyleneimine antibacterial material of n-octanoyl modification, comprises the following steps:

[0042] (1) Preparation of n-octanoyl modified branched polyethyleneimine

[0043] In a three-necked flask, dissolve 500 mg of branched polyethyleneimine (weight average molecular weight 10Kda) and 278 μL of triethylamine in 15 mL of anhydrous N, N dimethylformamide, stir to completely dissolve the above-mentioned substances, and then vigorously stir Slowly add 5 mL of anhydrous N,N dimethylformamide solution in which 325 mg of octanoyl chloride was dissolved (the molar ratio of branched polyethyleneimine monomer units to octanoyl chloride is 6:1) dropwise. After the dropwise addition, react at 70°C for 24h. After the reaction, the reaction mixture was transferred to a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed in 1 L of ultrapure water for 48 hours to remove organic solvents and small molecular ...

Embodiment 3

[0050] 1, a kind of preparation method of the branched polyethyleneimine antibacterial material of n-octanoyl modification, comprises the following steps:

[0051] (1) Preparation of n-octanoyl modified branched polyethyleneimine

[0052] In a three-necked flask, dissolve 500 mg of branched polyethyleneimine (weight average molecular weight 10Kda) and 278 μL of triethylamine in 15 mL of anhydrous N, N dimethylformamide, stir to completely dissolve the above-mentioned substances, and then vigorously stir Slowly add 5 mL of anhydrous N,N dimethylformamide solution in which 325 mg of octanoyl chloride was dissolved (the molar ratio of branched polyethyleneimine monomer units to octanoyl chloride is 6:1) dropwise. After the dropwise addition, react at 70°C for 24h. After the reaction, the reaction mixture was transferred to a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed in 1 L of ultrapure water for 48 hours to remove organic solvents and small molecular ...

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Abstract

The invention discloses a novel functional polymer material capable of enhancing a photodynamic antibacterial effect as well as a preparation method and application of the novel functional polymer material. The preparation method comprises the following steps: adding capryloyl chloride, branched polyethyleneimine and triethylamine into an organic solvent, carrying out a heating reaction, and after the reaction is finished, carrying out purification to obtain n-capryloyl-modified branched polyethyleneimine. The n-octanoyl-modified branched polyethyleneimine antibacterial material disclosed by the invention and a hydrophobic photosensitizer are made into a water-based dispersing agent which shows antibacterial performance, and meanwhile, the n-octanoyl-modified branched polyethyleneimine also has interaction with a bacterial surface structure; and the n-octanoyl-modified branched polyethyleneimine can more quickly penetrate gram-negative bacteria with a complete surface structure, and a photosensitizer wrapped in the n-octanoyl-modified branched polyethyleneimine nanoparticles wrapped with the photosensitizer can be conveyed to the vicinity of a bacterial cell membrane, so that the n-octanoyl-modified branched polyethyleneimine nanoparticles show an effective inhibition effect on bacteria.

Description

technical field [0001] The invention relates to the field of antibacterial materials, in particular to a novel functional polymer material capable of enhancing the photodynamic antibacterial effect and its preparation method and application. Background technique [0002] Microorganisms are an important part of the natural biosphere, and their impact on the natural environment is extremely significant. However, microorganisms also contain a variety of pathogenic bacteria and fungi that pose a huge threat to human health. However, due to the abuse of antibiotics in disease treatment all the time, making Bacterial drug resistance is increasing year by year, and bacterial drug resistance has become a global health problem. [0003] In the exploration of new methods against drug-resistant bacteria in recent years, antimicrobial photodynamic therapy (PACT) has been found to have great potential in overcoming bacterial drug resistance. However, due to the regular structure of the ...

Claims

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Application Information

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IPC IPC(8): C08G73/04A61K9/51A61K47/34A61K41/00A61P31/04
CPCC08G73/0206A61K9/5146A61K9/5192A61K41/0057A61P31/04
Inventor 王倩谢小保施庆珊张丹丹王玲玲冯劲
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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