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A novel functional polymer material capable of enhancing photodynamic antibacterial effect and its preparation method and application

A reaction and photosensitizer technology, applied in the field of new functional polymer materials and their preparation, can solve the problems of reduced treatment efficiency of Gram-negative bacteria, mammalian cell toxicity, adverse tissue reactions, etc., to increase the content of photosensitizers, Enhance the effect of photodynamic antibacterial effect and strong structure and function

Active Publication Date: 2022-07-19
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the regular structure of the outer cell layer of Gram-negative bacteria, they show very strong resistance to various photosensitizers, and it is difficult for photosensitizers to penetrate the outer layer of the cell structure and enter the interior of the cell, making PACT resistant to Gram-negative bacteria. The treatment efficiency of bacteria is greatly reduced
According to the characteristics of such bacteria, researchers will use outer membrane disrupting agents in the process of bacterial PACT, which are often used to increase the sensitivity of bacteria to PACT, but these agents may be potentially toxic to mammalian cells or cause tissue damage. Adverse reactions

Method used

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  • A novel functional polymer material capable of enhancing photodynamic antibacterial effect and its preparation method and application
  • A novel functional polymer material capable of enhancing photodynamic antibacterial effect and its preparation method and application
  • A novel functional polymer material capable of enhancing photodynamic antibacterial effect and its preparation method and application

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Effect test

Embodiment 1

[0033] (1) Preparation of branched polyethyleneimine modified with n-octanoyl group

[0034] In a three-necked flask, dissolve 500 mg of branched polyethyleneimine (weight-average molecular weight 10Kda) and 278 μL of triethylamine in 15 mL of anhydrous N,N-dimethylformamide, stir to completely dissolve the above substances, and then stir vigorously. 5 mL of anhydrous N,N dimethylformamide solution dissolved in various amounts of octanoyl chloride (OC) was slowly added dropwise. After the dropwise addition, the reaction was carried out at 70° C. for 24 h. After the reaction, the reaction mixture was transferred into a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed in 1 L of ultrapure water for 48 hours to remove the organic solvent and small molecular impurities produced by the reaction. During dialysis, the ultrapure water was changed every 6 hours. After the dialysis, the retentate in the dialysis bag was removed, and after freezing, the retentate wa...

Embodiment 2

[0041] 1. A preparation method of a branched polyethyleneimine antibacterial material modified by n-octanoyl group, comprising the following steps:

[0042] (1) Preparation of branched polyethyleneimine modified with n-octanoyl group

[0043] In a three-necked flask, dissolve 500 mg of branched polyethyleneimine (weight-average molecular weight 10Kda) and 278 μL of triethylamine in 15 mL of anhydrous N,N-dimethylformamide, stir to completely dissolve the above substances, and then stir vigorously. 5 mL of anhydrous N,N-dimethylformamide solution in which 325 mg of octanoyl chloride was dissolved was slowly added dropwise (the molar ratio of branched polyethyleneimine monomer units to octanoyl chloride was 6:1). After the dropwise addition, the reaction was carried out at 70° C. for 24 h. After the reaction, the reaction mixture was transferred into a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed in 1 L of ultrapure water for 48 hours to remove the orga...

Embodiment 3

[0050] 1. A preparation method of a branched polyethyleneimine antibacterial material modified by n-octanoyl group, comprising the following steps:

[0051] (1) Preparation of branched polyethyleneimine modified with n-octanoyl group

[0052] In a three-necked flask, dissolve 500 mg of branched polyethyleneimine (weight-average molecular weight 10Kda) and 278 μL of triethylamine in 15 mL of anhydrous N,N-dimethylformamide, stir to completely dissolve the above substances, and then stir vigorously. 5 mL of anhydrous N,N-dimethylformamide solution in which 325 mg of octanoyl chloride was dissolved was slowly added dropwise (the molar ratio of branched polyethyleneimine monomer units to octanoyl chloride was 6:1). After the dropwise addition, the reaction was carried out at 70° C. for 24 h. After the reaction, the reaction mixture was transferred into a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed in 1 L of ultrapure water for 48 hours to remove the orga...

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Abstract

The invention discloses a novel functional polymer material capable of enhancing photodynamic antibacterial effect, and a preparation method and application thereof. The invention also discloses a preparation method thereof: adding octanoyl chloride, branched polyethyleneimine and triethylamine into an organic solvent, heating for reaction, and purifying to obtain branched polyethyleneimine modified by n-octanoyl after the reaction. The n-octanoyl-modified branched polyethyleneimine antibacterial material disclosed in the present invention exhibits antibacterial properties when prepared into an aqueous dispersion with a hydrophobic photosensitizer, and the n-octanoyl-modified branched polyethyleneimine also interacts with bacteria. The surface structure has interactions, and the n-octanoyl-modified branched polyethyleneimine can penetrate the Gram-negative bacteria with a complete surface structure more quickly, and the n-octanoyl-modified branched polyethyleneimine loaded with photosensitizers can be transferred. The photosensitizer encapsulated in the ethyleneimine nanoparticles was transported to the vicinity of the bacterial cell membrane, showing an effective inhibitory effect on bacteria.

Description

technical field [0001] The invention relates to the field of antibacterial materials, in particular to a novel functional polymer material capable of enhancing photodynamic antibacterial effect and a preparation method and application thereof. Background technique [0002] Microorganisms are an important part of the natural biosphere, and their impact on the natural environment is extremely significant. However, microorganisms also contain a variety of pathogenic bacteria and fungi that pose a great threat to human health. However, due to the abuse of antibiotics in the treatment of diseases, the The drug resistance of bacteria is increasing year by year, and bacterial drug resistance has become a global health problem. [0003] In recent years of new approaches to combat drug-resistant bacteria, antibacterial photodynamic therapy (PACT) has been found to have great potential in overcoming bacterial resistance. However, due to the regularity of the outer cell structure of G...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G73/04A61K9/51A61K47/34A61K41/00A61P31/04
CPCC08G73/0206A61K9/5146A61K9/5192A61K41/0057A61P31/04
Inventor 王倩谢小保施庆珊张丹丹王玲玲冯劲
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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