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A patch for the prevention of hand-foot syndrome

A syndrome and patch technology, applied in the field of medical devices, can solve problems such as the inability to effectively control the temperature adjustment of cold therapy, and achieve the effect of relieving pain

Active Publication Date: 2022-02-22
TIANJIN TUMOR HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when the temperature regulation of cold therapy cannot be effectively controlled, it is easy to produce the opposite effect to the physiological effect

Method used

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  • A patch for the prevention of hand-foot syndrome
  • A patch for the prevention of hand-foot syndrome

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A patch for preventing hand-foot syndrome, comprising a backing layer, a gel layer and a protective film arranged in sequence, the gel layer components and mass percentages are:

[0039] Polyvinyl alcohol 20-30%,

[0040] Sorbitol 2-5%,

[0041] Calcium carbonate 0.5-1%,

[0042] Pentaerythritol tetraglycidyl ether 0.3-0.5%,

[0043] Hydroxyl-containing water-absorbing resin 3-8%,

[0044] Amino acid 0.02-0.05%,

[0045] Hydroxypropyl methylcellulose 2-4%,

[0046] Nano Fe 2 o 3 1-2%,

[0047] Chinese medicine composition extract 3-5%,

[0048] Vitamin B6 0.05~0.1%,

[0049] The balance is water.

[0050] Preparation:

[0051] 1) Add polyvinyl alcohol to water and stir evenly, and dissolve in a water bath at 80-90°C to obtain an aqueous solution of polyvinyl alcohol;

[0052] 2) Add the remaining components to the above polyvinyl alcohol aqueous solution, stir evenly and place in a water bath at 25°C for crosslinking for 24 hours;

[0053] 3) After cross-l...

Embodiment 2

[0058] The method of embodiment 1 is repeated by the content of each component specified in the following table 1, but with nanometer Al 2 o 3 Substitute Nano Fe 2 o 3 , the test results are listed in Table 1.

Embodiment 3

[0060] The method of embodiment 1 is repeated by the content of each component specified in the following table 1, but with nanometer SiO 2 Substitute Nano Fe 2 o 3 , the test results are listed in Table 1.

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Abstract

The invention relates to a patch for preventing hand-foot syndrome, which comprises a backing layer, a gel layer and a protective film arranged in sequence, and the composition and mass percentage of the gel layer are: polyvinyl alcohol 20~ 30%, sorbitol 2-5%, calcium carbonate 0.5-1%, pentaerythritol tetraglycidyl ether 0.3-0.5%, water-absorbing resin 3-8%, amino acid 0.02-0.05%, hydroxypropyl methylcellulose 2-4 %, 1-2% of nanometer material, 3-5% of extract of traditional Chinese medicine composition, 0.05-0.1% of vitamin B6, and the balance is water. The gel layer of the present invention can control the temperature at 21-26°C for 5 hours, meeting the use requirement of maintaining a moderately low temperature (21-27°C) within 2-3 hours of injection time.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to hand-foot syndrome prevention technology, in particular to a patch for preventing hand-foot syndrome. Background technique [0002] Hand-foot syndrome (HFS), also known as palmoplantar sensory loss erythema syndrome, is a relatively frequent dose-limiting local skin toxicity reaction, which can be cured by the new anthracycline pegylated liposomal doxorubicin, Capecitabine, fluorouracil, sorafenib and other chemotherapy drugs. HFS may appear at the earliest 3-5 days after the initial treatment, and its early symptoms include erythema, significant discomfort, swelling, or tingling on the palms and toes of the palms and toes, and blistering or even ulceration in severe cases; dark-skinned patients may be accompanied by pigmentation Calmness and thickening of the skin. HFS is most likely to appear in the palms and soles of the feet, and other parts such as the armpit, groin, waist, in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F7/02A61K9/70A61K36/56A61P17/00A61P25/02A61K31/4415
CPCA61F7/02A61K36/237A61K36/232A61K36/268A61K36/258A61K36/48A61K36/56A61K33/22A61K36/21A61K36/324A61K31/4415A61K9/7053A61K9/7046A61P17/00A61P25/02A61F2007/0036A61F2007/0045A61F2007/0226A61F2007/0261A61F2007/0287A61F2007/0219
Inventor 王晴何欣贾辛婕王淼
Owner TIANJIN TUMOR HOSPITAL