Protein marker TPI1 related to respiratory syncytial virus and detection kit

A technology for syncytial virus and respiratory tract, which is applied in the field of respiratory syncytial virus-related protein markers and detection kits, and can solve the problem of lack of recognized indicators, easy errors, and difficulty in meeting the sensitivity and specificity of biomarkers at the same time. problems, to achieve stable results, accurate diagnosis, and easy access to materials.

Active Publication Date: 2021-06-01
GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the sensitivity and specificity of the existing biomarkers for diagnosing RSV infection are difficult to meet at the same time, and are related to the examiner's sampling method and operation level, which are easy to cause errors, so they have not been confirmed by a large clinical cohort
So far, there is still no recognized indicator and method

Method used

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  • Protein marker TPI1 related to respiratory syncytial virus and detection kit
  • Protein marker TPI1 related to respiratory syncytial virus and detection kit
  • Protein marker TPI1 related to respiratory syncytial virus and detection kit

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Experimental program
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Effect test

Embodiment 1

[0051] 1. Serum sample preparation

[0052] 1ml of nasopharyngeal secretions were collected from healthy children and children with RSV-infected bronchiolitis, and placed in 2ml of normal saline. Among them, the children were divided into two groups: 20 cases in the acute RSV infection period and 20 cases in the recovery period, and 20 healthy children as the control group. RSV antigens were detected using direct immunofluorescence. After syncytial virus infection was confirmed, peripheral blood from children in the acute phase or convalescent phase and healthy age / sex-matched children was collected, centrifuged at 1000g for 10 min, serum samples were collected, and stored at -80°C. The guardians of all children involved in this study provided written informed consent, and this study was approved by the Ethics Committee of Guangzhou Women and Children's Medical Center [2015101501] and conducted in accordance with the World Medical Association Code of Ethics (Declaration of He...

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Abstract

The invention discloses application of TPI1 protein as a biomarker for detecting respiratory syncytial virus infection in a sample. The invention further provides a kit for diagnosing respiratory syncytial virus infection. The respiratory syncytial virus infection condition in a sample can be rapidly, simply and specifically detected, and the kit has important clinical diagnosis value and clinical significance for early and rapid diagnosis of respiratory syncytial virus infection.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a protein marker related to respiratory syncytial virus and a detection kit thereof. Background technique [0002] Respiratory syncytial virus (RSV) is a single-stranded negative-sense RNA virus belonging to the genus Pneumovirus in the Paramyxoviridae family, and is the most common viral pathogen of acute lower respiratory tract infection (ALRTI) in infants and young children. , especially in children under 2 years of age, there is a high risk and is closely related to subsequent wheeze attacks and asthma. Among children with acute respiratory tract infection, 12% to 63% are related to RSV infection. After RSV infection, older children may only show mild upper respiratory symptoms, but young infants are more likely to develop severe lower respiratory symptoms. Respiratory tract infection, the most common lower respiratory tract disease is bronchiolitis, which can also c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/573
CPCG01N33/573G01N2333/99G01N2800/26
Inventor 印根权曾慧璇彭智钦陈晨肖密丝曾强吴佩琼曾洁敏江文辉陈焕辉
Owner GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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