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High-energy-density fat emulsion as well as preparation method and application thereof

A high energy density, fat emulsion technology, applied in the field of biomedicine, can solve the problems of insufficient energy density and low stability

Active Publication Date: 2021-06-04
麦孚营养科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are generally defects such as low stability and insufficient energy density.

Method used

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  • High-energy-density fat emulsion as well as preparation method and application thereof
  • High-energy-density fat emulsion as well as preparation method and application thereof
  • High-energy-density fat emulsion as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1: fat emulsion preparation

[0049] The composition of fat emulsion is:

[0050]

[0051] The preparation of fat emulsion comprises the following steps:

[0052] (1) Add sucralose, xanthan gum, and food flavors into preheated purified water, control the temperature at 60-70°C, stir at 6000r / min until completely dissolved, and obtain the aqueous phase.

[0053] (2) Add mono- and diglyceride fatty acid esters, polyglycerol fatty acid esters, sucrose fatty acid esters, and vitamin E to preheated canola oil, medium-chain triglycerides, and fish oil, and control the temperature at 60- Stir at 70°C and 10000r / min until completely dispersed to obtain an oil phase.

[0054] (3) Mix the oil phase and the water phase, and shear at a high speed of 10,000 r / min for 30 minutes to obtain colostrum; homogenize the obtained colostrum under high pressure at 60° C. and 600 bar.

[0055] (4) Fill the homogenized emulsion into a glass bottle, seal and airtight.

[0056] ...

Embodiment 2

[0057] Embodiment 2: fat emulsion preparation

[0058] The composition of fat emulsion is:

[0059]

[0060] The preparation method of fat emulsion is: comprise the following steps:

[0061] (1) Add sucralose, xanthan gum, and food flavors into preheated purified water, control the temperature at 60-70°C, stir at 6000r / min until completely dissolved, and obtain the aqueous phase.

[0062] (2) Add mono- and diglyceride fatty acid esters and tert-butyl hydroquinone to the preheated canola oil, medium-chain triglycerides and fish oil, control the temperature at 60-70°C, 10000r / min Stir until completely dispersed to obtain an oily phase.

[0063] (3) Mix the oil phase and the water phase, and shear at a high speed of 10,000 r / min for 30 minutes to obtain colostrum; homogenize the obtained colostrum under high pressure at 60° C. and 600 bar.

[0064] (4) Fill the homogenized emulsion into a glass bottle, seal and airtight.

[0065] (5) The product is sterilized in a water ba...

Embodiment 3

[0066] Embodiment 3: fat emulsion preparation

[0067] The composition of fat emulsion is:

[0068]

[0069] The preparation method of fat emulsion is: comprise the following steps:

[0070] (1) Add sucralose, sodium carboxymethylcellulose, sodium caseinate, and food flavors to preheated purified water, control the temperature at 60-70°C, stir at 6000r / min until completely dissolved, and obtain water Mutually.

[0071] (2) Add citric acid fatty acid glycerides, diacetyl tartaric acid mono-diglycerides, and tert-butyl hydroquinone to the preheated canola oil, medium-chain triglycerides, and fish oil, and control the temperature at 60- Stir at 70°C and 10000r / min until completely dispersed to obtain an oil phase.

[0072] (3) Mix the oil phase and the water phase, and shear at a high speed of 10,000 r / min for 30 minutes to obtain colostrum; homogenize the obtained colostrum under high pressure at 60° C. and 600 bar.

[0073] (4) Fill the homogenized emulsion into a glass ...

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Abstract

The invention relates to a fat emulsion with high energy density. The emulsion contains 10-40% (w / w) of low-erucic acid rapeseed oil, 10-45% (w / w) of medium-chain triglyceride, 0.5-10% (w / w) of fish oil, 1-10% (w / w) of a compound emulsifier and a pharmaceutically acceptable carrier. The fat emulsion can effectively supplement EPA, DHA and energy required by patients, and has the advantages of high energy density, good stability, high biological absorbance and the like.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a fat emulsion with high energy density, a preparation method thereof and an application thereof. Background technique [0002] Fat emulsions are ideal for intravenous administration to provide energy and essential fatty acids. Most of the fat emulsion injections widely used in clinical practice use soybean oil as raw material, or prepare soybean oil and medium-chain triglycerides (C6-C8) by physical or chemical methods as raw materials. Fat emulsion injection can better meet the clinical needs of general patients, but its content of omega-6 polyunsaturated fatty acids, especially linoleic acid, is relatively high. Long-term use may affect the body's immune system, especially the body's inflammatory response There are adverse effects. [0003] In the 1980s, medium / long-chain fat emulsions with fish oil as the main raw material were developed. Compared with products deriv...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/14A61K31/23A61K35/60A61K36/31A61P3/02
CPCA61K9/107A61K9/0019A61K47/14A61K31/23A61K35/60A61K36/31A61P3/02A61K2300/00
Inventor 刘春芝李阳阳刘丽丽郭庆新白云
Owner 麦孚营养科技有限公司
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