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10-undecylenylamino methyl ethyl propionate and preparation method and application thereof in mosquito repelling

A technology of ethyl enoylaminomethylpropionate and ethyl propionate, which is applied in the field of ethyl 10-undecylaminomethylpropionate and its preparation, and can solve toxic and side effects, neurotoxicity, and user occurrence Erythema, urticaria and other problems, to achieve the effect of low toxicity, safe use, and expand the use value

Active Publication Date: 2021-06-04
INST OF ZOOLOGY GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If there are certain toxic and side effects, it may cause symptoms such as erythema and urticaria in the user; it has certain solubility to chemical fiber clothing; it has certain permeability and irritation to the skin
It may even cause neurotoxicity, and it has been found that mosquitoes may develop resistance to DEET

Method used

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  • 10-undecylenylamino methyl ethyl propionate and preparation method and application thereof in mosquito repelling
  • 10-undecylenylamino methyl ethyl propionate and preparation method and application thereof in mosquito repelling
  • 10-undecylenylamino methyl ethyl propionate and preparation method and application thereof in mosquito repelling

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Compound Synthesis Method

[0030] Preparation of ethyl 10-undecylaminomethylpropionate: In a 500 mL three-neck reaction flask equipped with a stirring device, dropping funnel and thermometer, add 40 g of 10-undecylenoyl chloride and 80 mL of diethyl ether. Slowly add 20 g of 3-(methylamino) ethyl propionate dropwise in the dropping funnel, pay attention to the boiling situation, control the speed of dripping 3-(methylamino) ethyl propionate (about 0.5g / min), let the reaction process Steady, the reaction temperature is 30°C to 40°C. After dropping, continue to stir for 1h. Then, 100 mL of 5% sodium hydroxide aqueous solution was added to the reactant, stirred thoroughly for 1 h, and the reaction was completed. Then the ether layer was separated and extracted. The ether layer was washed once more with 5% aqueous sodium hydroxide solution. Then the ether layer was washed once with 10% hydrochloric acid solution and water respectively. It was dried over anhydrous sodi...

Embodiment 2

[0040] Same as Example 1, the difference is: step a continues to stir the reaction for 0.5h, the mass volume ratio of 10-undecenoyl chloride and ether is 1:1g / mL, 10-undecenoyl chloride and 3-(methylamino ) The mass ratio of ethyl propionate is 1.5:1.

Embodiment 3

[0042] Same as Example 1, the difference is: Step a continues to stir the reaction for 2h, the mass volume ratio of 10-undecenoyl chloride and ether is 1:3g / mL, 10-undecenoyl chloride and 3-(methylamino) The mass ratio of ethyl propionate is 2.5:1.

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PUM

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Abstract

The invention discloses 10-undecylenylamino methyl ethyl propionate and a preparation method and application thereof in mosquito repelling. The structural formula of the compound 10-undecylenylamino methyl ethyl propionate is as shown in a formula I in the specification. The compound has the advantages of simple synthesis process route, easily available raw materials, low toxicity, no allergy, no irritation and safety in use, and has a good mosquito repelling effect; and the effective protection time of 10-undecylenyl amino methyl ethyl propionate with the mass fraction of 10% is 8.3 + / -1.0 h, and the 10-undecylenyl amino methyl ethyl propionate reaches the A-level standard of the part 9: repellent of GB / T13917.9-2009 laboratory efficacy test and evaluation of sanitary insecticide for pesticide registration, and has further research and expanded application values.

Description

Technical field: [0001] The invention belongs to the technical field of mosquito repelling, and in particular relates to ethyl 10-undecylaminomethyl propionate, a preparation method thereof and an application in mosquito repelling. Background technique: [0002] Since DEET was reported as an effective repellent in the 1950s, it is still used as a standard repellent in most countries and regions, and is currently the most widely used mosquito repellent. But people found that DEET has some disadvantages in use. If there are certain toxic and side effects, it may cause symptoms such as erythema and urticaria in the user; it has certain solubility to chemical fiber clothing; it has certain permeability and irritation to the skin. It may even cause neurotoxicity, and it has been found that mosquitoes may develop resistance to DEET. Thereby the research of finding new species repellent and overcoming existing shortcoming is going on all the time. Invention content: [0003] T...

Claims

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Application Information

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IPC IPC(8): C07C233/49C07C231/02A01N37/46A01P17/00
CPCC07C233/49A01N37/46
Inventor 吴华戴建青陈大嵩黄鸿郑基焕
Owner INST OF ZOOLOGY GUANGDONG ACAD OF SCI
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