A degradable 3D printed sinus stent loaded with drugs and preparation method thereof

A technology for loading drugs and printing noses. It is applied in the fields of manufacturing, medical science, prosthesis, etc. It can solve problems such as poor effect, and achieve the effect of improving drug utilization rate and effective cycle.

Active Publication Date: 2022-07-19
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the outcome of this procedure is often poor due to postoperative nasal adhesions and sinus re-atresia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Using PLA as raw material and mometasone furoate as auxiliary drug, a drug-loaded 3D printed sinus stent was prepared by 3D printing technology. The preparation steps of this degradable nasal cavity and sinus stent are as follows:

[0020] (1) Use CAD software to design the three-dimensional structure of the sinus stent and the two-dimensional grid structure after horizontally spreading it, and obtain parameters such as the size and angle of each part of the stent material; the obtained three-dimensional sinus stent and its two-dimensional grid The structural parameters are converted into STL format and input to the 3D printer;

[0021] (2) According to the parameters input in step (1), select PLA with a molecular weight of 100,000 as the main raw material, and prepare a two-dimensional PLA mesh material with 12 continuous diamond meshes through the 3D printing process. The side length of the mesh is 10mm, The carrier substrate printed by the material is a groove templ...

Embodiment 2

[0026] Using PLA as raw material and moxixa hydrochloride as auxiliary drug, a 3D printed sinus stent loaded with drugs was prepared by 3D printing technology. The preparation steps of this degradable nasal cavity and sinus stent are as follows:

[0027] (1) Use CAD software to design the three-dimensional structure of the sinus stent and the two-dimensional grid structure after horizontally spreading it, and obtain parameters such as the size and angle of each part of the stent material; the obtained three-dimensional sinus stent and its two-dimensional grid The structural parameters are converted into STL format and input to the 3D printer;

[0028] (2) According to the parameters input in step (1), select PLA with a molecular weight of 150000 as the main raw material, and prepare a two-dimensional PLA mesh material with 10 continuous diamond meshes through the 3D printing process, and the side length of the mesh is 10mm, The carrier substrate printed by the material is a g...

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Abstract

The invention discloses a degradable 3D printing nasal sinus stent loaded with drugs and a preparation method thereof. The stent can be implanted after sinus dilation to prevent nasal adhesion, and the stent can be slowly degraded along with the release of drugs, which can affect the lesion location. Continue treatment with medication. The invention uses degradable PLA material as raw material, adopts 3D printing technology, and fuses the drug load into the process of forming the 3D printing material. The drug release cycle of the stent is consistent with the material degradation cycle, which can meet the time requirement for wound healing after sinus dilation surgery, and can effectively solve the problem of short drug release time for general drug-coated stents. The degradable drug support for the nasal cavity and paranasal sinuses obtained by the invention can reduce mucosal inflammation and edema, promote mucosal healing, reduce scar formation, and eliminate postoperative adhesions, thereby alleviating the pain of patients and reducing the economic burden of patients.

Description

technical field [0001] The invention discloses a drug-loaded 3D printed sinus stent and a preparation method thereof. The stent can be implanted after sinus dilation to prevent nasal adhesion, and the stent can be slowly degraded along with the release of the drug, and the drug can be administered to the lesion site. Continue treatment. The degradable drug stent for the nasal cavity and paranasal sinuses obtained by the invention can reduce mucosal inflammation and edema, promote mucosal healing, reduce scar formation, and eliminate postoperative adhesions, thereby reducing pain and economic burden of patients. Background technique [0002] For common ENT diseases such as chronic sinusitis and nasal polyps, the most common surgical method at present is endoscopic surgery, that is, to remove the lesions, open the blocked sinuses, and rebuild and restore the physiological functions of the nasal cavity and sinuses. However, this procedure is often less effective due to postope...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/18A61L31/06A61L31/14A61L31/16B29C64/10B33Y10/00B33Y80/00
CPCA61F2/18B29C64/10B33Y10/00B33Y80/00A61L31/06A61L31/16A61L31/148A61F2240/002A61F2250/0067A61L2300/602A61L2300/41A61L2300/40A61L2300/412A61L2300/424C08L67/04A61M31/00A61L2300/222A61L2300/406A61L2300/604B33Y50/00
Inventor 刘杨
Owner CHANGZHOU UNIV
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