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Degradable temperature-sensitive mesoporous silicon nanoparticle system for light controlled release drugs

A nanoparticle and mesoporous silicon technology, which is applied in the field of medicine, can solve the problems of weakening the drug-carrying capacity of the carrier, controlling the release process, and not being able to drug, and achieve the effect of reducing the cumulative toxicity

Active Publication Date: 2021-06-15
济南国科医工科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing reports, the photosensitizer and the chemical drug are co-loaded in the pores of mesoporous silicon. This design will not only weaken the drug-loading ability of the carrier for a single drug, but also cannot achieve the controlled release of the drug well. process

Method used

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  • Degradable temperature-sensitive mesoporous silicon nanoparticle system for light controlled release drugs
  • Degradable temperature-sensitive mesoporous silicon nanoparticle system for light controlled release drugs
  • Degradable temperature-sensitive mesoporous silicon nanoparticle system for light controlled release drugs

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preparation example Construction

[0056] refer to figure 1 The preparation method of the degradable temperature-sensitive mesoporous silicon nanoparticle system for light-controlled drug release comprises the following steps:

[0057] 1) preparing diselenide-bridged mesoporous silicon particles;

[0058] 2) Coating a temperature-sensitive layer on the surface of the diselenide-bridged mesoporous silicon particles to obtain temperature-sensitive mesoporous silicon particles;

[0059] 3) Loading chemicals on the mesoporous silicon particles inside the temperature-sensitive mesoporous silicon particles;

[0060] 4) loading a photosensitizer on the surface of the temperature-sensitive mesoporous silicon particles to obtain the degradable temperature-sensitive mesoporous silicon nanoparticle system for light-controlled drug release.

[0061] figure 1 Among them, 1 represents the diselenide-bridged mesoporous silicon particles, 2 represents the temperature-sensitive layer, 3 represents the chemical drug, and 4 re...

Embodiment 1

[0067] The preparation method of the degradable temperature-sensitive mesoporous silicon nanoparticle system for light-controlled drug release provided in this example includes the following steps:

[0068] 1. Preparation of diselenide-bridged mesoporous silicon nanoparticles: MSN

[0069] Get 0.6g cetyltrimethylammonium toluenesulfonate (CTAT) and 0.15g triethanolamine (TEAH 3 ) into 40 mL of deionized water, stirred at 80°C for 30 min, and then added bis[3-(triethoxysilyl)propyl] diselenide (BTESePD) and ethyl orthosilicate dropwise according to the mass ratio of 1 to 8. Mixture of esters (TEOS) (mixture of TEOS and BTESePD: CTAT and TEAH 3 reaction product=1~8), continue to stir for 4 hours, after three times of centrifugation washing with ethanol, adopt 1% ​​ammonium nitrate to reflux the product after centrifugation washing for 12h; wash with ethanol again, obtain the mesoporous of diselenide bridge Silicon particles: MSN, saved for future use.

[0070] 2. Preparation ...

Embodiment 2

[0082] Embodiment 2: the performance measurement of nanoparticle

[0083] 1. Infrared characterization of MSN, MSN-MPS and MSN-NIPAM

[0084] The powders of MSN, MSN-MPS and MSN-NIPAM were taken respectively for infrared measurement, the results are shown in figure 2 . It can be seen that when MPS is coupled, the -CH of MPS can be observed at 3000-2750 nm. 2 and -CH 3 Signal, when the temperature-sensitive layer is further coated, the -C=O and N-H signals of NIPAM can be observed between 1700 and 1500 nm, indicating the successful preparation of MSN-NIPAM.

[0085] 2. Thermogravimetric analysis (TGA) of MSN, MSN-MPS and MSN-NIPAM

[0086] 10 mg of MSN, MSN-MPS and MSN-NIPAM powders were taken respectively for thermogravimetric analysis. The test conditions were to raise the temperature at a rate of 10°C / min under a nitrogen flow of 100mL / min, and measure the mass change of each substance from room temperature to 800°C. The results are as follows image 3 As shown, it can...

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Abstract

The invention discloses a degradable temperature-sensitive mesoporous silicon nanoparticle system for light controlled release drugs, which comprises diselenide-bridged mesoporous silicon particles, chemical drugs loaded on the diselenide-bridged mesoporous silicon particles, a temperature-sensitive layer coated outside the diselenide-bridged mesoporous silicon particles, and a photosensitizer loaded on the temperature-sensitive layer. According to the invention, a diselenide-bridgeddegradable mesoporous silicon drug delivery system coated with the temperature-sensitive layer is constructed, mesoporous silicon particles at the core part have oxidation-reduction dual response properties, which are easier to degrade at a tumor part, so that the accumulation toxicity caused by a carrier material is reduced; and on the other hand, different from the common way that two medicines are loaded into the pore channel of the mesoporous silicon particle, the system provided by the invention loads chemical medicines and photosensitizers in stages, so that the function of controlling the release of the chemical medicines in the pore channel through the light-operated switch pore channel can be realized, and finally, the treatment mode of combining the photodynamic force and the chemical medicines is realized.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a degradable temperature-sensitive mesoporous silicon nanoparticle system for light-controlled drug release. Background technique [0002] In today's world, cancer has become one of the major diseases that threaten human health, and chemotherapy, as the mainstream therapy, has become one of the indispensable methods in the treatment of various tumors. However, most chemical drugs have disadvantages such as poor water solubility, poor stability, and lack of targeting, which are likely to cause a variety of toxic and side effects; Drug resistance can not control the development of the disease well, and even bring great pain to patients. Therefore, the development of a drug delivery system with high efficiency and low toxicity, and the combination of multiple cancer treatment methods has become a current research hotspot. [0003] Mesoporous silicon nanoparticles have the advant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/04A61K47/32A61K47/34A61K41/00A61K31/704A61K31/4375A61P35/00
CPCA61K9/5115A61K9/5192A61K9/5138A61K9/5146A61K41/0052A61K41/0057A61K41/0071A61K41/0042A61K31/704A61K31/4375A61P35/00A61K2300/00
Inventor 董文飞彭佳惠梅茜葛明锋从瑛哥常智敏李力宁珊珊
Owner 济南国科医工科技发展有限公司
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