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Degradable thermosensitive mesoporous silicon nanoparticle system for photocontrolled drug release

A nanoparticle and mesoporous silicon technology, which is applied in the field of medicine, can solve the problems of weakening the drug-carrying capacity of the carrier, controlling the release process, and incapable of drugs, and achieving the effect of reducing the accumulated toxicity

Active Publication Date: 2022-03-08
济南国科医工科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the existing reports, the photosensitizer and the chemical drug are co-loaded in the pores of mesoporous silicon. This design will not only weaken the drug-loading ability of the carrier for a single drug, but also cannot achieve the controlled release of the drug well. process

Method used

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  • Degradable thermosensitive mesoporous silicon nanoparticle system for photocontrolled drug release
  • Degradable thermosensitive mesoporous silicon nanoparticle system for photocontrolled drug release
  • Degradable thermosensitive mesoporous silicon nanoparticle system for photocontrolled drug release

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preparation example Construction

[0056] Refer figure 1 The preparation method of the degradable temperature-sensitive meshal silicon nanoparticle system of the optical controlled release drug includes the following steps:

[0057] 1) Prepare di selenium bridged mesoporous silicon particles;

[0058] 2) The temperature-sensitive layer is coated on the surface of the mesenteric silicon particles of the di selenium bridge, and the temperature-sensitive mesolane particles are obtained;

[0059] 3) The chemical is loaded on the mesoporous silicon particles inside the temperature-sensitive mesh silicon particles;

[0060] 4) Load the photosensitizer to the surface of the temperature-sensitive mesh particles to obtain a degradable temperature-sensitive meson-nanoparticle system of the photointed release.

[0061] figure 1 In the middle, 1 represents the messenilone particles of the selenium bridge, 2 represents the temperature sensitive layer, 3 represents a chemical, 4 represents a photosensitive agent.

Embodiment 1

[0067] The preparation method of the degradable temperature-sensitive meson silicon nanoparticle system provided by the optical controlled release of the present embodiment includes the following steps:

[0068] 1. Preparation of Die Silicone Nanoparticles of Sillenium Bridge: MSN

[0069] Take 0.6 g of tetraalkyltryltrylmethylsulfonate (CTAT) and 0.15 g of triethanolamine (TEAH 3 Add to 40 ml of deionized water, stirred at 80 ° C for 30 min, according to the mass ratio 1 to 8, add double [3- (triethylene oxyhalisilyl) propyl] group selenide (Btesepd) and orthodoxate Ester (TEOS) mixture (TEOS with Btesepd mixture: ctat with teah 3 The reaction product = 1 to 8), continued for 4 hours, washed three times with ethanol, was washed with 1% ammonium nitrate refluxed 12 h after centrifugation; then washed with ethanol to obtain a di selenium bridge connection Silicon particles: MSN, preservation for use.

[0070] 2, preparation temperature sensitivity cardicon particles: MSN-NIPAM

[0...

Embodiment 2

[0082] Example 2: Determination of properties of nanoparticles

[0083] First, the infrared character of MSN, MSN-MPS and MSN-NIPAM

[0084] The powder of MSN, MSN-MPS and MSN-NIPAM was taken, respectively, and the results were seen figure 2 . It can be seen that after the MPS is coupled, the MPS can be observed at 3000 ~ 2750 nm. 2 -CH 3 Signal, when further coating the temperature sensitive layer, NIPAM-C = O and N-H signals were observed between 1700 to 1500 nm, indicating successful preparation of MSN-NIPAM.

[0085] Second, MSN, MSN-MPS and MSN-NIPAM thermal analysis (TGA)

[0086] Take MSN, MSN-MPS, and MSN-NIPAM powder 10 mg for thermal weight analysis, the test conditions were at 10 ° C / min, and the mass change of each substance at room temperature to 800 ° C was measured at 10 ° C / min. image 3 As shown, it can be seen that there is no significant difference in mass after MPS coupling, and the temperature sensitive layer composed by NIPAM and PEI accounts for about 10%...

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Abstract

The invention discloses a degradable temperature-sensitive mesoporous silicon nanoparticle system for light-controlled drug release, which comprises: diselenide-bridged mesoporous silicon particles, and chemical drugs loaded on the diselenium-bridged mesoporous silicon particles , a temperature-sensitive layer coated on the outside of the diselenide-bridged mesoporous silicon particles, and a photosensitizer loaded on the temperature-sensitive layer. The present invention constructs a diselenide-bridged degradable mesoporous silicon drug delivery system coated with a temperature-sensitive layer. The mesoporous silicon particles in the core part have dual redox response properties, and are easier to degrade at the tumor site, thereby reducing the carrier material. On the other hand, unlike the common two drugs co-loaded into the mesoporous silicon particle channel, this system loads the chemical drug and the photosensitizer in stages, so that the photo-controlled switch channel can be realized To control the function of chemical drug release, and finally realize the combined treatment mode of photodynamic and chemical drugs.

Description

Technical field [0001] The present invention relates to the field of drug technology, and more particularly to a degradable temperature-sensitive mesolane silicon nanoparticle system for optical controlled release. Background technique [0002] In today's world, cancer has become one of the main diseases that threaten human health, and chemotherapy has become an indispensable means of the treatment period of each tumor treatment. However, most chemicals have a poor water solubility and stability, lack of targeting, etc., which is easy to cause multiple poisonous side effects; on the other hand, single chemotherapy often does not play long-lasting effects, and there are many days of administration Pharmaceutical phenomenon, can't control the development of disease, even bring great pain to patients. Therefore, developing a highly efficient, low toxic administration system, and combining a variety of cancer treatment methods have become the current research hotspot. [0003] The me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K47/04A61K47/32A61K47/34A61K41/00A61K31/704A61K31/4375A61P35/00
CPCA61K9/5115A61K9/5192A61K9/5138A61K9/5146A61K41/0052A61K41/0057A61K41/0071A61K41/0042A61K31/704A61K31/4375A61P35/00A61K2300/00
Inventor 董文飞彭佳惠梅茜葛明锋从瑛哥常智敏李力宁珊珊
Owner 济南国科医工科技发展有限公司
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