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Implantable flexible magnetic response artificial bladder basal body and manufacturing method thereof

An artificial bladder and manufacturing method technology, applied in the field of biomedicine, can solve the problems of limited hydraulic pressure, human muscle level is very different, lack of realistic medical design and biological safety, etc., to achieve good biocompatibility, high density, The effect of high modulus

Active Publication Date: 2021-06-18
武汉磁济科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] This application provides an implantable flexible magnetic response artificial bladder matrix and its manufacturing method, which solves or partially solves the problem of the limited hydraulic pressure provided by the artificial detrusor muscle in the prior art, which is far from the human muscle level and lacks realistic medical design. And the optimization of biological safety, the technical problem of being unable to achieve reliable long-term function; the realization of providing a matrix that can be made into an implantable flexible magnetic response artificial bladder, benefiting from the high coercive force of the permanent magnetic particles in the ferromagnetic composite And distributed actuation source, ferromagnetic shows reliable actuation while outputting a large amount of magnetic force, acting as an artificial detrusor muscle to squeeze and empty the bladder

Method used

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  • Implantable flexible magnetic response artificial bladder basal body and manufacturing method thereof

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Experimental program
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Effect test

Embodiment 1

[0048] The uncured matrix was first prepared by uniformly mixing two silicone-based materials, Ecoflex 00-30 (Smooth-on Inc) and PDMS resin (Sylgard 184, Dow Corning) at a volume ratio of 5:1 using a planetary mixer Composite rubber, at a speed of 800rpm for 2 minutes, defoaming for 1 minute. For Ecoflex 00-30 components, the volume ratio of Part A and Part B is 1:1.

[0049] The uncured ferromagnetic composite was prepared by uniformly mixing NdFeB particles with a volume fraction of 25% and an average particle size of 5 μm with the uncured matrix composite compound on a 10-speed gear with a vibrating mixer for 2 minutes, and defoaming for 1 minute.

[0050] Add 5.5wt% platinum-containing curing agent into the uncured ferromagnetic composite, stir evenly and then cure, and the above operation is completed within 30 minutes. The ferromagnetic composite was obtained by curing at 40°C for 4 hours. The magnetic particles in the ferromagnetic composite are uniformly magnetized i...

Embodiment 2

[0055] The uncured matrix was first prepared by homogeneously mixing two silicone-based materials, Ecoflex 00-30 (Smooth-on Inc) and PDMS resin (Sylgard 184, Dow Corning) at a volume ratio of 6:1 using a planetary mixer Composite rubber, at a speed of 800rpm for 3 minutes, defoaming for 1 minute. For Ecoflex 00-30 components, the volume ratio of Part A and Part B is 1:1.

[0056] The uncured ferromagnetic composite was prepared by uniformly mixing NdFeB particles with a volume fraction of 30% and an average particle size of 5 μm with the uncured matrix composite compound on a 10-speed gear with a vibrating mixer for 4 minutes, and defoaming for 1 minute.

[0057] Add 7.85wt% platinum-containing curing agent into the uncured ferromagnetic composite, stir evenly and then cure, and the above operations are completed within 30 minutes. The ferromagnetic composite was obtained by curing for 10 h at 40°C. The magnetic particles in the ferromagnetic composite are uniformly magnetiz...

Embodiment 3

[0062] The uncured matrix was first prepared by homogeneously mixing two silicone-based materials, Ecoflex 00-30 (Smooth-on Inc) and PDMS resin (Sylgard 184, Dow Corning) at a volume ratio of 9:1 using a planetary mixer Composite rubber, at a speed of 1200rpm for 3 minutes, defoaming for 1 minute. For Ecoflex 00-30 components, the volume ratio of Part A and Part B is 1:1.

[0063] The uncured ferromagnetic composite was prepared by uniformly mixing NdFeB particles with a volume fraction of 40% and an average particle size of 5 μm with the uncured matrix composite compound on a 10-speed gear with a vibrating mixer for 6 minutes, and defoaming for 1 minute.

[0064] Add 9.09wt% platinum-containing curing agent into the uncured ferromagnetic composite, stir evenly and then cure, and the above operation is completed within 30 minutes. The ferromagnetic composite was obtained by curing at 42°C for 20 hours. The magnetic particles in the ferromagnetic composite are uniformly magne...

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Abstract

The invention relates to an implantable flexible magnetic response artificial bladder basal body. The implantable flexible magnetic response artificial bladder basal body comprises a flexible non-magnetic basal body and a ferromagnetic complex bonded with the flexible non-magnetic basal body; the flexible non-magnetic basal body comprises the following components: organic silica gel and polydimethylsiloxane resin, the volume ratio of the organic silica gel to the polydimethylsiloxane resin is (4-10): 1, the ferromagnetic complex comprises the following components: organic silica gel, polydimethylsiloxane resin and magnetic particles, the volume ratio of the organic silica gel to the polydimethylsiloxane resin is (4-10): 1, and the volume fraction of the magnetic particles in the ferromagnetic basal body is 20-40%. The implantable flexible magnetic response artificial bladder basal body can be manufactured into a basal body of the implantable flexible magnetic response artificial bladder, benefits from high coercive force of permanent magnet particles in the ferromagnetic complex and distributed actuating sources, the ferromagnetism shows reliable actuating, meanwhile, a large amount of magnetic force is output, and the effect of an artificial detrusor muscle is achieved to extrude and empty the bladder.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an implantable flexible magnetic response artificial bladder matrix and a manufacturing method thereof. Background technique [0002] The rapid development of soft robots applied in the biomedical field aims to improve medical conditions and provide novel therapeutic tools, such as surgical instruments, human simulation and drug delivery. As a class of highly compliant and biocompatible active systems, soft robots hold great promise in assisting organ movement and even reconstructing organs. Efforts have been made to use soft-bodied robots in prosthetic assistive devices for various diseased muscles such as cardiac muscle, hand muscles, and sphincters. [0003] Underactive bladder (UAB) is characterized by prolonged urination due to weak muscle contraction, leading to serious complications and even death. Affected by age, neurological diseases, trauma and diabetes, the incid...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/06A61L31/10A61L31/14C09D183/04
CPCA61L31/14A61L31/10A61L31/028A61L31/06C09D183/04A61L2420/04C08L83/04
Inventor 臧剑锋吴清扬凌青羊佑舟王佳鑫凌乐杨甲申
Owner 武汉磁济科技有限公司
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