Cefradine capsule preparation

Abstract

The invention provides a cefradine capsule preparation, the prescription of the preparation is as follows: 64%-79% of cefradine, 24%-34% of a filler, 0.2%-3% of a disintegrating agent, 0.5%-5% of a lubricant and 0.01%-1% of a cosolvent, and the invention provides a preparation method thereof. The preparation formula and the process cooperate to solve the problem that operators have the risk of pneumoconiosis due to the fact that a large amount of talcum powder is used in the production process; the problems that raw material medicines in the mixed materials exist in the form of fine powder, and the product content is not uniform due to layering of auxiliary material particles and the fine powder of the raw material medicines in the capsule filling production process are solved.

Description

technical field [0001] The invention belongs to the field of chemical preparations, and in particular relates to a cephradine capsule preparation and a preparation method thereof. Background technique [0002] This product is the first-generation semi-synthetic cephalosporin, and its antibacterial effect is similar to that of cephalexin. This product is acid-resistant and can be taken orally, with good absorption and high blood concentration. It is characterized by resistance to β-lactamase, and has rapid and reliable bactericidal effect on drug-resistant Staphylococcus aureus and other bacilli resistant to broad-spectrum antibiotics. , It is mainly excreted in the urine in the original form, and the concentration in the urine is relatively high. It is mainly used clinically for infections of the respiratory tract, urinary tract, skin and soft tissues, such as bronchitis, pneumonia, pyelonephritis, cystitis, ear, nose and throat infections, enteritis and dysentery. At pres...

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Problems solved by technology

[0003] At present, talcum powder and starch are granulated by wet method, and then the granules are dried in an oven. There is inevitable dust in the production process. Talc powder is a magnesium silicate salt. Talc powder is very fine and easily enters the lungs through the respiratory tract, but the human body cannot absorb it. Digestion, there is a higher risk of pneumoconiosis; in the mixed material, the raw material drug exists in the form of fine powder, and the production process of capsule filling is separated from the excipient particles and the raw material drug, resulting in uneven product content

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