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Paracetamol abdominal navel patch and preparation method thereof

An acetaminophen and umbilical sticking technology, applied in the field of medicine, can solve the problems of large individual differences, short action time, slow onset, etc., achieve thin blood vessel distribution, facilitate rapid absorption, and avoid gastrointestinal discomfort. Effect

Pending Publication Date: 2021-06-29
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the lack of ideal administration routes and dosage forms of acetaminophen in clinical practice, the present invention provides a paracetamol abdominal umbilical patch, which has the advantages of quick onset, long-lasting effect, and convenient use, and overcomes the problem of oral acetaminophen. The ubiquitous shortcomings of aminophenol are large individual differences, slow onset of action, obvious adverse reactions in the gastrointestinal tract, and short-term action time. It also avoids problems such as local pain caused by intramuscular injection, and has good clinical application value and significance.

Method used

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  • Paracetamol abdominal navel patch and preparation method thereof
  • Paracetamol abdominal navel patch and preparation method thereof
  • Paracetamol abdominal navel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1. Preparation of Acetaminophen Abdominal Umbilical Patch

[0042] (1) Cut the medical elastic sponge into a hemispherical shape that can match the navel of the human body, put it into the coating solution (the coating solution is 20% ethyl cellulose ethanol solution) for 3 minutes, take it out, and place it at 42°C After drying, a sponge hemisphere wrapped with a non-porous ethylcellulose film was obtained, which was bonded to the middle position of the backing layer.

[0043] (2) prepare paracetamol gel, concrete composition and percentage by weight thereof are: paracetamol 2.0%, guar gum 2.0%, propylene glycol 12%, citric acid 0.8%, surplus is distilled water, preparation steps: Dissolve acetaminophen in a mixed solution of propylene glycol and distilled water, boil, sprinkle guar gum when cooled to 60°C, stir, add 40% citric acid to neutralize, stir to form a gel, and spread it evenly on the fast On the medical elastic sponge hemisphere in the drug release area and...

Embodiment 2

[0054] 1. Preparation of Acetaminophen Abdominal Umbilical Patch

[0055] (1) Cut the medical elastic sponge into a hemispherical shape that can match the navel of the human body, put it into the coating solution (the coating solution is 20% ethyl cellulose ethanol solution) for 3 minutes, take it out, and place it at 45°C After drying, a sponge hemisphere wrapped with a non-porous ethylcellulose film was obtained, which was bonded to the middle position of the backing layer.

[0056] (2) prepare paracetamol gel, concrete composition and percentage by weight thereof are: paracetamol 2.5%, guar gum 2.5%, propylene glycol 15%, citric acid 1.1%, surplus is distilled water, preparation step: Dissolve acetaminophen in a mixed solution of propylene glycol and distilled water, boil, sprinkle guar gum when cooled to 65°C, stir, add 40% citric acid to neutralize, stir to form a gel, and spread it evenly on the fast On the medical elastic sponge hemisphere in the drug release area and ...

Embodiment 3

[0067] 1. Preparation of Acetaminophen Abdominal Umbilical Patch

[0068] (1) Cut the medical elastic sponge into a hemispherical shape that can match the navel of the human body, put it into the coating solution (the coating solution is 20% ethyl cellulose ethanol solution) for 3 minutes, take it out, and place it at 48°C After drying, a sponge hemisphere wrapped with a non-porous ethylcellulose film was obtained, which was bonded to the middle position of the backing layer.

[0069] (2) prepare paracetamol gel, concrete composition and weight percent thereof are: paracetamol 3.0%, guar gum 3.0%, propylene glycol 18%, citric acid 1.4%, surplus is distilled water, preparation step: Dissolve acetaminophen in a mixed solution of propylene glycol and distilled water, boil, sprinkle guar gum when cooled to 70°C, stir, add 40% citric acid to neutralize, stir to form a gel, and spread it evenly on the fast On the medical elastic sponge hemisphere in the drug release area and the ba...

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Abstract

The invention discloses a paracetamol abdominal navel patch and a preparation method thereof, and belongs to the technical field of medicines. The paracetamol abdominal navel patch comprises a backing layer, an abdominal navel patch body and a protective film, wherein the abdominal navel patch body covers the backing layer; the protective film covers the surface of the abdominal navel patch body; the abdominal navel patch body sequentially comprises a quick drug release area, a controlled drug release area and a sticking area from the center to the outside; the quick drug release area comprises a paracetamol gel layer and medical elastic sponge coated with a non-porous ethyl cellulose film; the controlled drug release area comprises a porous ethyl cellulose film layer and a paracetamol gel layer; and the sticking area is a pressure-sensitive adhesive. The paracetamol abdominal navel patch provided by the invention has the advantages of quick response, long action time, convenience in use and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an acetaminophen abdominal navel patch and a preparation method thereof. Background technique [0002] Fever, commonly known as fever, is a symptom that the body's body temperature exceeds the normal range under the action of a pyrogen or when the thermoregulatory center is dysfunctional. Symptoms such as profuse sweating, prostration, and rapid heart rate. Excessive body temperature or too long time can cause various regulatory dysfunctions of the body, decreased immunity, indigestion, increased myocardial oxygen consumption, excessive consumption of own substances, and impaired central nervous system functions. Thermal analgesic treatment. [0003] Antipyretic and analgesic drugs commonly used in clinic mainly include anilines (such as acetaminophen), salicylates (such as acetylsalicylic acid), propionic acids (such as naproxen), COX-2 inhibitors (such as methacr...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K47/10A61K31/167A61P29/00
CPCA61K9/7023A61K47/38A61K47/10A61K31/167A61P29/00Y02A50/30
Inventor 王咏懿蒋曙光
Owner CHINA PHARM UNIV
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