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A kind of n-ha/cs porous scaffold for bone repair and its preparation method and application

A porous scaffold and bone repair technology, which is applied in the direction of prosthesis, coating, tissue regeneration, etc., can solve the problems of poor plasticity and single porous bone repair scaffold structure, and achieve improved osteoconductivity, simple raw material formula, and promote bone repair Effect

Active Publication Date: 2022-04-08
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a bone repair n-HA / CS porous scaffold and its preparation method and application, which solves the problems of single structure and poor plasticity of the traditional porous bone repair scaffold, and provides a convenient solution for the load and application of drugs or functional growth factors. Slow and controlled release provides the basis for

Method used

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  • A kind of n-ha/cs porous scaffold for bone repair and its preparation method and application
  • A kind of n-ha/cs porous scaffold for bone repair and its preparation method and application
  • A kind of n-ha/cs porous scaffold for bone repair and its preparation method and application

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Embodiment 1

[0036] A kind of preparation method of bone repair n-HA / CS porous scaffold, see figure 1 , the method contains:

[0037] (1) Preparation of glutaraldehyde cross-linked chitosan microspheres

[0038] A certain amount of chitosan acetic acid solution was prepared with an acetic acid solution with a mass fraction of 1.5 wt%, and the mass fraction of chitosan in the chitosan acetic acid solution was 2 wt%.

[0039] Take 28.0g of chitosan acetic acid solution and add it to 84.0g of liquid paraffin, 1.6g of Span80 and 0.4g of Tween80, stir rapidly at room temperature for 30min to form a white milky W / O emulsion, add 2mL of pentadiene to this W / O emulsion Aldehyde solution (50%), continue to stir for 2-3 hours, fully wash with petroleum ether and isopropanol, centrifuge, and dry overnight at 45°C to obtain brown glutaraldehyde cross-linked chitosan microsphere powder.

[0040] (2) Preparation of n-HA / CS porous scaffold loaded with CS microspheres

[0041] Dissolving chitosan (CS) ...

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Abstract

The invention discloses a n-HA / CS porous scaffold for bone repair and its preparation method and application. The bone repair scaffold uses the n-HA / CS porous scaffold as the basic structure, and the surface of the n-HA / CS porous scaffold is modified by dopamine A dopamine coating is formed, and chitosan microspheres cross-linked by glutaraldehyde are grafted on the surface of the dopamine coating. The n-HA / CS porous scaffold for bone repair of the present invention has simple raw material formula, safe ingredients, good biocompatibility, biodegradability, and the functions of promoting osteogenesis and vascularization, and can effectively promote osteogenesis in the process of bone defect reconstruction. At the same time, the surface-grafted CS microspheres can be loaded with drugs and growth factors, which provides a basis for further construction of a functional bone repair system that can perform local drug / growth factor controlled release.

Description

technical field [0001] The invention relates to a medical porous support, in particular to a n-HA / CS porous support for bone repair, its preparation method and application. Background technique [0002] Osteomyelitis is a serious orthopedic disease caused by microbial infection with a long history. Often results in localized bone defect or even necrosis. Survey data show that the infection rate of open bone and joint injuries can be as high as 5%-25%, and the resulting incidence of traumatic osteomyelitis has also greatly increased. At the same time, in clinical routine operations, complications such as postoperative wound infection and bone exposure after open reduction and internal fixation of fractures are not uncommon. another important reason. Once infected with osteomyelitis, if it is not treated in time or treated thoroughly, it will develop into chronic osteomyelitis, which will eventually lead to suppurative joints, periosteal abscess, pyomyositis, deep vein thro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/34A61L27/54A61L27/56A61L27/58B33Y70/10
CPCA61L27/46A61L27/34A61L27/54A61L27/56A61L27/58B33Y70/10A61L2300/112A61L2300/412A61L2300/602A61L2430/02C08L5/08C08L79/04
Inventor 邹琴李玉宝林明玥王晨鑫李泰赫
Owner SICHUAN UNIV
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