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In-vivo-like heart organ chip and method

An organ-on-a-chip and heart technology, applied in the fields of micro-electromechanical engineering and biomedicine, can solve the problems of small signal-to-noise ratio and difficulty in packaging into a confined space

Pending Publication Date: 2021-06-29
QILU UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

A disadvantage of this method is that it is difficult to package the inside of the cavity into a closed space, resulting in a signal-to-noise ratio of less than 3

Method used

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Embodiment Construction

[0034] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0035] It should be noted that the terminology used here is only for describing specific embodiments, and is not intended to limit exemplary embodiments according to the present invention. As used herein, unless the invention clearly states otherwise, the singular form is also intended to include the plural form. In addition, it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, their Indicate the presence of features, steps, operations, means, components and / or combinations thereof;

[0036] For the convenience of description, if the words "up", "down", "left" and "right" appear in th...

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Abstract

The invention discloses an in-vivo heart organ chip and method. The in-vivo heart organ chip comprises a substrate device and a culture solution perfusion device, wherein a PDMS thin film is arranged on a surface of the substrate device, and the culture solution perfusion device is arranged at a top of the PDMS thin film to simulate blood flowing condition; the substrate device comprises a substrate, a PDMS mold is arranged on a surface of the substrate, and the PDMS mold is provided with a micro gas channel; the PDMS thin film comprises a suspended thin film, and the suspended thin film is provided with a strain sensing part, an induction electrode and a stimulating electrode.

Description

technical field [0001] The invention belongs to the technical fields of micro-electromechanical engineering and biomedicine, and in particular relates to an in-vivo heart organ chip and a method thereof. Background technique [0002] The statements herein merely provide background information related to the present invention and do not necessarily constitute prior art. [0003] Globally, cardiac dysfunction-induced cardiovascular death accounts for 33% of the total death toll, ranking first in the global death toll. [0004] At present, the existing micro-nano sensor devices for myocardial contractility (or stress) detection have the following types: [0005] The electrical impedance method (Electrical impedance) was proposed by Gievar et al. In this method, cardiomyocytes are planted on the interdigitated microelectrode array chip, and the distance between the bottom of the cell and the upper surface of the electrode is changed during the beating process of the cells, ther...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/42C12M1/34C12M1/04
CPCC12M29/10C12M35/02C12M35/04C12M41/00
Inventor 王力陈俊苏伟光李安庆刘鹏博许崇海陈照强
Owner QILU UNIV OF TECH
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