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Application of Danzhi Qing'e prescription in preparation of medicine for treating and/or preventing benign prostatic hyperplasia

A technique for prostatic hyperplasia and educated youth, which is applied in the field of medicine to achieve the effects of improving symptoms of bladder obstruction, tissue lesions and symptoms

Active Publication Date: 2021-07-09
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the common clinical drugs for the treatment of BPH include 5α-reductase inhibitors, α-receptor blockers, etc., which have significant curative effects in inhibiting the increase of prostate volume, but there are certain side effects

Method used

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  • Application of Danzhi Qing'e prescription in preparation of medicine for treating and/or preventing benign prostatic hyperplasia
  • Application of Danzhi Qing'e prescription in preparation of medicine for treating and/or preventing benign prostatic hyperplasia
  • Application of Danzhi Qing'e prescription in preparation of medicine for treating and/or preventing benign prostatic hyperplasia

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0047] The preparation of the extract of preparation example 1 Danzhiqing'e Fang

[0048] (1) Take 800g salt psoraleae, add 1600mL, 70% ethanol aqueous solution to soak for 12 hours, and use 70% ethanol aqueous solution at 8mL / kg·min -1 Flow rate percolation to obtain 12000mL percolation liquid, recover ethanol under reduced pressure, concentrate to the quality of salt psoralen: the volume of the concentrated solution is 1:1.5, let stand to separate layers, pour off the upper layer, and take the lower layer to obtain the first extract. Store at 4°C.

[0049] (2) Take 1600g Danshen decoction pieces, add 3200mL, 95% ethanol aqueous solution to soak for 24 hours, and use 95% ethanol aqueous solution at 16mL / kg·min -1 Percolation at a flow rate to obtain 9,600 mL of percolation liquid and percolation dregs of Danshen medicine. The percolation liquid was decompressed to recover ethanol, concentrated to a relative density of 1.15 (50°C), and vacuum-dried at 65°C to obtain a fat-sol...

Embodiment 1

[0052] Example 1 Danzhiqing'e Fang inhibits the effect of benign prostatic hyperplasia in rats

[0053] Forty 8-week-old SPF male Wistar rats, weighing 240±20g, were subjected to castration after one week of adaptive feeding. Randomly select 8 rats as the sham operation group to perform sham operation, and the remaining 32 rats undergo castration operation, completely remove the bilateral testes and epididymis, and intramuscularly inject 0.3 mL / rat / day of penicillin one week after the operation. The post-potential rats were randomly divided into 4 groups: model group, low-dose group, middle-dose group, and high-dose group. Dosing began 21 days after the operation, among them, the sham operation group, subcutaneously injected corn oil 0.1ml / d, and intragastrically administered normal saline 3ml / d; model group, low-dose group, middle-dose group, high-dose group, subcutaneously injected Estradiol / testosterone (E2 / T, the concentration ratio is 1:100, the final concentration of E2...

Embodiment 2

[0060] Example 2 Improvement of Danzhiqing'e Prescription on Bladder Obstruction in Rats

[0061]Ninety-six 8-week-old SPF male Wistar rats, weighing 225±25g, were adaptively fed for one week, and underwent partial ligation of the bladder neck through the retropubic approach. 16 rats were randomly selected as the sham operation group to perform sham operation, and the remaining 80 rats underwent partial bladder neck ligation through the retropubic approach, and all intramuscularly injected gentamicin 0.5mL / rat / rat in the inner thigh after operation. day, for 3 consecutive days. After ligation, the rats were adaptively fed for one week, and then randomly divided into 3 groups: model group, middle-dose group, and high-dose group. Dosing began 7 days after the operation. Among them, the sham operation group and the model group were given intragastric administration of normal saline 3ml / d respectively; the middle dose group and the high dose group were administered intragastric a...

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Abstract

The invention provides application of a Danzhi Qing'e prescription in preparation of a medicine for treating and / or preventing benign prostatic hyperplasia, further provides application of the Danzhi Qing'e prescription in preparation of a medicine for treating and / or preventing bladder obstruction caused by benign prostatic hyperplasia, a pharmaceutical composition containing an extract of the Danzhi Qing'e prescription, and application of the pharmaceutical composition in preparation of medicines for treating and / or preventing benign prostatic hyperplasia and in preparation of medicines for treating and / or preventing bladder obstruction caused by benign prostatic hyperplasia. The Danzhi Qing'e prescription can obviously inhibit the volume increase of prostate, improve the tissue lesion of prostatic hyperplasia and improve the symptoms of benign prostatic hyperplasia, so the Danzhi Qing'e prescription is used for treating benign prostatic hyperplasia; and the Danjiaqing'e prescription also can obviously inhibit the volume increase of the bladder, improve the tissue lesion of bladder obstruction and enhance the symptoms of bladder obstruction, so the Danzhi Qing'e prescription is used for treating bladder obstruction caused by benign prostatic hyperplasia.

Description

technical field [0001] The application relates to the technical field of medicine, in particular to the use of Danzhiqing'e Fang in the preparation of medicines for treating and / or preventing benign prostatic hyperplasia. Background technique [0002] Benign prostatic hyperplasia (BPH) is a high-incidence species of the urinary system in middle-aged and elderly men, which is closely related to age. Epidemiological studies have shown that 50% of men over the age of 60 can observe BPH symptoms at the tissue level; the prevalence of BPH in men over the age of 80 is close to 90%. The prostate is semi-surrounded around the bladder neck urethra, which is an inverted chestnut-shaped solid glandular organ. When it proliferates to a certain extent, it compresses the bladder exit urethra and causes it to deform, resulting in increased urethral resistance and difficulty in urinating, which in turn causes bladder dysfunction. Increased volume and bladder tissue lesions are bladder obst...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P13/08A61P13/10
CPCA61K36/487A61K36/537A61K36/46A61K36/8964A61P13/10A61P13/08A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 高秀梅苗琳刘二伟张晗常艳旭毛浩萍杨晓华吴垚锌
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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