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Combined medicine and application

A technology of drugs and uses, applied in the field of combined drugs and uses, can solve problems such as sexual dysfunction, achieve the effect of inhibiting the increase of volume, improving tissue lesions, and having a good clinical application prospect

Active Publication Date: 2021-12-07
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the common clinical BPH drugs include 5α-reductase inhibitors, α-receptor blockers, etc. These two types of drugs are often used in combination to treat benign prostatic hyperplasia and concurrent lower urinary tract symptoms. While relieving the symptoms of BPH, these drugs often cause various adverse reactions such as sexual dysfunction, dizziness, hypotension, etc.

Method used

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  • Combined medicine and application
  • Combined medicine and application
  • Combined medicine and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The improvement effect of embodiment 1 combination medicine on benign prostatic hyperplasia and lower urinary tract symptoms

[0036] Preparation of Cynomorium extract: Take 3kg Cynomorium decoction pieces, add 24L of 60% ethanol solution to heat and reflux extraction twice, each time for 2h, evaporate the extract in a rotary evaporator, freeze-dry in a freeze dryer to obtain Cynomorium Extract;

[0037] Preparation of Phellodendron Phellodendri Extract: Take 3kg Phellodendron Phellodendri Slices, add 30L 60% ethanol solution to heat and pressurize to extract twice, 2 hours each time, combine the extracts, filter, distill under reduced pressure to obtain extract, and dry in vacuum to obtain Phellodendron Phellodendri Extract thing.

[0038] Take 108 specific pathogen-free (SPF grade) male Wistar rats, weighing 230-250 g, and start castration after one week of adaptive feeding. 12 rats were randomly selected and subjected to sham surgery. The scrotal skin, capsule tiss...

Embodiment 2

[0047] Embodiment 2 Combined use of drugs on E in rat serum 2 , T, E 2 Effects of / T and DHT

[0048] The inventor found in the study that the imbalance of estrogen and androgen levels occurs in patients with benign prostatic hyperplasia and lower urinary tract symptoms, especially in clinical practice, E 2 / T is one of the effective indicators for the treatment of benign prostatic hyperplasia and lower urinary tract symptoms. It is generally considered that E 2 The lower the value of / T, the better the drug treatment effect. The application of estradiol (E) in rat serum 2 ), testosterone (T), estradiol / testosterone (E 2 / T), the content of dihydrotestosterone (DHT) has been detected, thereby verifying the therapeutic effect of the combined drug of the present application on prostatic hyperplasia and lower urinary tract symptoms.

[0049] In embodiment 1, blood was taken from the abdominal aorta of each group of rats after administration, and supernatant was obtained by c...

Embodiment 3

[0051] The influence of embodiment 3 combination drugs on rat maximum urination pressure

[0052] In embodiment 1, bladder perfusion is done to each group of rats to detect urination parameters, and the detection results of each group of rats' maximum voiding pressure (MVP) are as follows: Figure 9 As shown, the bladder perfusion is to anesthetize the rats in each group by intraperitoneal injection, fix the supine position, press the lower abdomen of the rats to discharge residual urine from the bladder; open the abdominal cavity, separate and cut the ureter, and ligate the ureter near the bladder end; insert the venous needle from the top of the bladder, The flexible tube on the other side of the venous needle is connected to the microperfusion pump, and the signal is collected and recorded by the four-channel pressure sensor PowerLab8 / 30. Before the experiment, the background level of pressure in the rat bladder was set to zero. At room temperature, the bladder was perfuse...

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Abstract

The invention provides a combined medicine which comprises a cynomorium songaricum extract and a cortex phellodendri extract, and the weight ratio of single medication of the cynomorium songaricum extract to single medication of the cortex phellodendri extract is 1:(1.0-1.5). The invention further provides application of the combined medicine in preparation of medicine for preventing and / or treating benign prostatic hyperplasia and lower urinary tract symptoms. The combined medicine provided by the invention can inhibit the increase of the prostate volume, reduce the prostate index and the bladder index, improve the tissue lesions of the prostate and the bladder, reduce the estradiol / testosterone level, reduce the maximum urination pressure and increase the tension of the detrusor muscle strip, so that the combined medicine can be used for preventing and / or treating prostatic hyperplasia and lower urinary tract symptoms, and the combined medicine is further used for preparing medicines for preventing and / or treating benign prostatic hyperplasia and lower urinary tract symptoms. The combined medicine disclosed by the invention has a synergistic effect, is suitable for long-term treatment and has a good clinical application prospect.

Description

technical field [0001] The application relates to the technical field of medicine, in particular to a combined drug and its application. Background technique [0002] Benign prostatic hyperplasia (BPH) is a high-incidence species of the urinary system in middle-aged and elderly men, which is closely related to age. Epidemiological studies have shown that 50% of men over the age of 60 can observe BPH symptoms at the tissue level; the prevalence of BPH in men over the age of 80 is close to 90%. As the volume of the prostate continues to increase, it will compress the bladder neck and narrow the urethra, eventually leading to varying degrees of lower urinary tract symptoms such as frequent urination, urgency, incontinence, and bladder outlet obstruction (Lower Urinary Tract symptoms, LUTs), in severe cases, bilateral upper urinary tract hydrops may occur and lead to renal insufficiency. If the treatment is not timely, it will easily lead to serious complications such as hematu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P13/08A61P13/02A61P13/10
CPCA61K36/185A61K36/756A61P13/08A61P13/02A61P13/10A61K2300/00
Inventor 苗琳高秀梅刘二伟王亚静常艳旭马亚宣吴垚锌
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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