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Use of Danzhiqing'e Fang in the preparation of medicines for treating and/or preventing benign prostatic hyperplasia

A prostatic hyperplasia and drug technology, applied in the field of medicine, to achieve the effects of improving tissue lesions, improving symptoms, and inhibiting the increase of bladder volume

Active Publication Date: 2022-07-22
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the common clinical drugs for the treatment of BPH include 5α-reductase inhibitors, α-receptor blockers, etc., which have significant curative effects in inhibiting the increase of prostate volume, but there are certain side effects

Method used

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  • Use of Danzhiqing'e Fang in the preparation of medicines for treating and/or preventing benign prostatic hyperplasia
  • Use of Danzhiqing'e Fang in the preparation of medicines for treating and/or preventing benign prostatic hyperplasia
  • Use of Danzhiqing'e Fang in the preparation of medicines for treating and/or preventing benign prostatic hyperplasia

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0047] Preparation Example 1 Preparation of the extract of Danzhiqing'e Fang

[0048] (1) Take 800g salt psoralea, add 1600mL, 70% ethanol aqueous solution to soak for 12 hours, use 70% ethanol aqueous solution at 8mL / kg·min -1 Flow rate percolation to obtain 12000mL percolation liquid, recover ethanol under reduced pressure, and concentrate to the quality of salt psoralea: the volume of the concentrated liquid is 1:1.5, stand for stratification, pour off the upper layer liquid, and take the lower layer to obtain the first extract. Store at 4°C.

[0049] (2) Take 1600g of Salvia miltiorrhiza slices, add 3200mL of 95% ethanol aqueous solution to soak for 24 hours, use 95% ethanol aqueous solution at 16mL / kg·min -1 Percolation at a flow rate to obtain 9600 mL of percolating liquid and salvia dregs after percolation. The percolating liquid was decompressed to recover ethanol, concentrated to a relative density of 1.15 (50°C), and vacuum-dried at 65°C to obtain a fat-soluble extr...

Embodiment 1

[0052] Example 1 The effect of Danzhi Qing'e recipe on inhibiting prostatic hyperplasia in rats

[0053] Forty 8-week-old SPF Wistar male rats, weighing 240 ± 20 g, underwent castration after one week of adaptive feeding. 8 rats were randomly selected as the sham operation group for sham operation, and the remaining 32 rats were subjected to castration operation to completely remove the bilateral testis and epididymis. Rats were randomly divided into 4 groups: model group, low-dose group, middle-dose group, and high-dose group. The administration started 21 days after operation. Among them, the sham operation group was given subcutaneous injection of corn oil 0.1ml / d, and intragastric administration of normal saline 3ml / d; the model group, low-dose group, middle-dose group, and high-dose group were subcutaneously injected Estradiol / testosterone (E2 / T, the concentration ratio is 1:100, the final concentration of E2 is 100μg / ml) 0.1ml / d, the model group was given intragastric a...

Embodiment 2

[0060] Example 2 The improvement effect of Danzhi Qing'e Fang on bladder obstruction in rats

[0061]Ninety-six 8-week-old SPF Wistar male rats, weighing 225 ± 25 g, were subjected to partial ligation of the bladder neck through the retropubic route after one week of adaptive feeding. 16 rats were randomly selected as the sham operation group for sham operation, and the remaining 80 rats were subjected to partial ligation of the bladder neck through the retropubic route, and gentamicin 0.5mL / rats / injection was performed intramuscularly on the inner thigh after the operation. days, 3 days in a row. Rats were reared adaptively for one week after ligation, and then randomly divided into three groups: model group, middle-dose group, and high-dose group. The administration started 7 days after the operation. Among them, the sham operation group and the model group were respectively administered with normal saline 3ml / d by intragastric administration; the middle-dose group and the ...

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Abstract

The present application provides the use of Danzhi Qing'e Fang in the preparation of medicines for the treatment and / or prevention of benign prostatic hyperplasia, and also provides the use of Danzhi Qing'e Fang in the preparation of medicines for the treatment and / or prevention of bladder obstruction caused by benign prostatic hyperplasia , and the pharmaceutical composition comprising the extract of Danzhiqing'e Fang, and its use in the preparation of a medicine for the treatment and / or prevention of benign prostatic hyperplasia and in the preparation of a medicine for the treatment and / or prevention of bladder obstruction caused by benign prostatic hyperplasia the use of. Danzhiqing'e formula can obviously inhibit the enlargement of prostate volume, improve the tissue lesions of benign prostatic hyperplasia, and improve the symptoms of benign prostatic hyperplasia, so as to be used for the treatment of benign prostatic hyperplasia; Danzhiqing'e formula can also significantly inhibit the increase of bladder volume and improve bladder obstruction. It can improve the symptoms of bladder obstruction and be used to treat bladder obstruction caused by benign prostatic hyperplasia.

Description

technical field [0001] The present application relates to the field of medical technology, in particular to the use of Danzhi Qing'e Fang in the preparation of a medicament for treating and / or preventing benign prostatic hyperplasia. Background technique [0002] Benign prostatic hyperplasia (BPH) is a high incidence of urinary system in middle-aged and elderly men, and is closely related to age. Epidemiological studies have shown that 50% of men over the age of 60 can observe BPH symptoms at the tissue level; the prevalence of BPH in men over the age of 80 is close to 90%. The prostate half surrounds the bladder neck urethra and is an inverted chestnut-shaped parenchyma gland organ. After hyperplasia to a certain extent, it compresses the bladder outlet urethra and deforms it, resulting in increased urethral resistance and difficulty in excretion of urine. The increased volume and bladder tissue lesions are called bladder obstruction. [0003] The age of BPH patients is g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61P13/08A61P13/10
CPCA61K36/487A61K36/537A61K36/46A61K36/8964A61P13/10A61P13/08A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 高秀梅苗琳刘二伟张晗常艳旭毛浩萍杨晓华吴垚锌
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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