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Carbazole content determination method based on high performance liquid chromatography

A technology of high performance liquid chromatography and determination method, which is applied in the field of determination of carbazole content based on high performance liquid chromatography, can solve the problems of inability to flow out of high boiling point components, poor accuracy, inconvenient operation, etc., and achieve scientific and reliable detection results. Effect

Pending Publication Date: 2021-07-13
GUANGDONG AGLAIA OPTOELECTRONICS MATERIALS
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

For GB / T 37175-2018 coking carbazole, due to its narrow scope of application and inconvenient operation, it is difficult to apply to the detection of general carbazole sample content; the detection method in HG / T 4259-2011 carbazole is difficult for complex components For samples with high boiling points, there may be high boiling point components that cannot flow out, and the accuracy of the area normalization method is poor, so the measured results may have a risk of large deviation from the actual content, which is not good for quality control

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  • Carbazole content determination method based on high performance liquid chromatography
  • Carbazole content determination method based on high performance liquid chromatography
  • Carbazole content determination method based on high performance liquid chromatography

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Embodiment 1

[0043] Example 1: Development and content determination of carbazole detection method

[0044] Experimental Instruments and Reagents

[0045] Agilent HPLC-1260 with G7115A-DAD detector; Sartorius SQP 1 / 100,000 analytical balance; 0.45 μm organic filter membrane; HPLC grade methanol, ultrapure water, acetone, dichloromethane; volumetric flask, pipette , Sample bottles and other glassware commonly used in laboratories.

[0046] 1. Development of high performance liquid phase content detection method for carbazole

[0047] 1.1 Solvent selection: At a concentration of 2 mg / mL, carbazole has good solubility in acetone, dichloromethane, and methanol. Methanol has relatively low volatility and has good mutual solubility with general reversed-phase chromatographic flow. Methanol is selected as the solvent.

[0048] 1.2 Detection wavelength selection: The main chromatographic parameters are: mobile phase: methanol; chromatographic column is Venusil XBP C184.6×250mm5μm; column tempera...

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Abstract

The invention relates to a carbazole content determination method based on high performance liquid chromatography, which comprises the following steps: selecting proper chromatographic conditions such as solvent, detection wavelength, chromatographic column, flow velocity and column temperature, adjusting the proportion of a mobile phase to separate a main substance from impurities, setting the gradient elution of the mobile phase to shorten the total detection time and improve the analysis efficiency. The method comprises the following steps: determining the main peak spectral purity of a final detection method by using a diode array detector, preparing standard solutions with different concentrations, drawing a standard curve, preparing a test solution, and measuring the carbazole content in a test by using an HPLC-UV external standard method.According to the method, the total analysis time is shorter than that of the standard method, and the detection result is more accurate and reliable than that of the standard method; and therefore, the method has important application significance.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and in particular relates to a method for measuring carbazole content based on high-performance liquid chromatography. Background technique [0002] Carbazole (carbazole), see the following structural formula (I), also known as dibenzopyrrole, 9-aza (hetero) fluorene, molecular formula is C 12 h 9 N, the molecular weight is 167.20, the melting point is 246-247°C, and the boiling point is 354.76°C. Carbazole is widely used in many fields, especially as an important intermediate raw material in organic synthesis of chemical pharmaceuticals, dyes, pesticides and plastics. . OLED has many advantages such as high brightness, wide viewing area and low energy consumption, and has a good development prospect in the display field. Carbazole, a nitrogen-containing heterocyclic compound with a unique structure, plays an important role in the development of new organic photoelectric materials. Carbazol...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/54G01N30/74G01N30/64
CPCG01N30/02G01N30/06G01N30/54G01N30/74G01N30/64G01N2030/027G01N2030/062
Inventor 徐炫宗潘统很何嘉升戴雷蔡丽菲
Owner GUANGDONG AGLAIA OPTOELECTRONICS MATERIALS