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Application of nobiletin in preparation of medicines for preventing or treating skin tissue diseases or symptoms related to application of chemotherapeutics

A chemotherapeutic drug, tangerine peel technology, applied in the field of biomedicine, can solve serious pain, skin swelling, erythema and other problems, achieve the effect of controlling skin side effects and preventing hand-foot syndrome

Pending Publication Date: 2021-07-16
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the administration of capecitabine has certain adverse reactions, such as the administration of capecitabine is easy to cause skin swelling and erythema, blisters or severe pain, in addition, dermatitis and hair loss are also common
[0004] Currently, there are no effective treatment options to manage the skin side effects associated with the administration of chemotherapy drugs like capecitabine, therefore, new options are urgently needed to fill this gap

Method used

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  • Application of nobiletin in preparation of medicines for preventing or treating skin tissue diseases or symptoms related to application of chemotherapeutics
  • Application of nobiletin in preparation of medicines for preventing or treating skin tissue diseases or symptoms related to application of chemotherapeutics
  • Application of nobiletin in preparation of medicines for preventing or treating skin tissue diseases or symptoms related to application of chemotherapeutics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Nobiletin alleviates the effect of 5-fluorouracil on the proliferation toxicity of HaCaT cells

[0033] The cultured skin cells HaCaT were digested, counted, seeded into a 96-well plate, and 5,000-10,000 cells were planted in each well. After culturing for 24 hours, each well was divided into a blank solvent control group, a 5-FU group, and a 5-FU+nobietin group. final concentration as figure 1 shown. After continuing to culture for 48 hours, the Cell Counting Kit-8 (CCK-8) detection kit (C0037, purchased from Shanghai Biyuntian Biotechnology Co., Ltd.) was used to measure the survival rate of the cells, so as to calculate the proliferation toxicity of 5-FU to the cells and the Sichuan Alleviating effect of nobiletin on proliferative toxicity. GraphPad Prism 6.0 software and t test were used for statistical analysis and drawing of the results. figure 1 Experimental results are listed.

Embodiment 2

[0034] Example 2 Nobiletin can alleviate the hand-foot syndrome caused by capecitabine on the rat model

[0035] Rat animal model was constructed. Capecitabine was given to 6-week-old female SD rats by intragastric administration every day. After a few days, hand-foot syndrome appeared in the paws of the rats (photograph as figure 2 shown). There is no difference between the left and right paws in the hands and feet, and the degree of hand-foot syndrome in the two paws is similar. Similar to humans, rats developed hand-foot syndrome in the paws after oral administration of capecitabine. The etiology of the two is exactly the same, and the symptoms are very similar. Therefore, rats are very good animal models for simulating capecitabine-induced hand-foot syndrome.

[0036] After the SD rats were reared and adapted for one week (about 200 g), the rats were divided into 12 in each group, and then the oral administration test was carried out. Capecitabine was dissolved in ca...

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Abstract

The invention relates to an application of nobiletin in preparation of medicines for preventing or treating skin tissue diseases or symptoms related to application of chemotherapeutics. According to the application method disclosed by the invention, the nobiletin can be used for preventing or treating skin tissue diseases or symptoms related to chemotherapeutics administrated in subjects. The nobiletin can be used for effectively controlling skin side effects caused by chemotherapeutics. The invention discovers that the nobiletin can relieve negative influence of a prodrug 5-fluorouracil of capecitabine on cell proliferation at the cellular level. The nobiletin can significantly prevent capecitabine-induced hand-foot syndromes in rats at the animal level.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of nobiletin in the preparation of medicines for preventing or treating skin tissue diseases or diseases related to the administration of chemotherapy drugs. Background technique [0002] Currently, chemotherapy is one of the main means of cancer treatment. Chemotherapy drugs can also damage normal tissues of patients while killing cancer cells, so chemotherapy often causes serious side effects, especially those that occur on the skin. Severe skin side effects caused by chemotherapy will impair the quality of life of patients and cause a decrease in the tolerance of patients to medication, which will adversely affect the therapeutic effect, lead to disease progression, and then affect the survival of patients. [0003] Capecitabine is a common anticancer drug, mainly used for advanced breast cancer and colorectal cancer, and can be used as a salva...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P17/00A61P17/04A61P17/14
CPCA61K31/352A61P17/00A61P17/04A61P17/14
Inventor 谢欣然张诗宜
Owner SHANGHAI JIAO TONG UNIV
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