Laboratory model system and method for development and characterization of preparation product filling process
A model system, laboratory technology, applied in teaching models, simulators, educational appliances, etc., can solve problems such as inspection and evaluation of shear stress that are not mentioned
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Embodiment 1
[0037] The PF6 peristaltic pump of Watson-Marlow Company was used as the metering filling pump 1, and a silicone tube with a length of 50 cm at both ends, an inner diameter of 4.8 mm, and a wall thickness of 1.6 mm was taken as the figure 1 In the pipe section 4 and pipe section 8, two silicone tubes with a length of 25cm, an inner diameter of 3.2mm, and a wall thickness of 1.6mm are figure 1 In the pipe section 2, select the appropriate Y-type interface 3 and 3' for connection. Fix the connected pipeline on the pump head of the peristaltic pump, connect a Bosch filling needle with an inner diameter of 3.5 mm on the solution outlet side, and place a polystyrene plastic bottle under the filling needle as a receiving container 5 . Bovine serum albumin (BSA) solution (viscosity about 1cp, histidine buffer, pH=6.0, sodium chloride 150mM, BSA concentration 15mg / mL) was selected as the simulated solution.
[0038] Set the filling volume of the peristaltic pump to 2.00mL, the pump s...
Embodiment 2
[0040] The PF6 peristaltic pump of Watson-Marlow Company was used as the metering filling pump 1, and a silicone tube with a length of 45 cm at both ends, an inner diameter of 4.8 mm, and a wall thickness of 1.6 mm was taken as the figure 1 In the pipe section 4 and pipe section 8, two silicone tubes with a length of 10cm, an inner diameter of 3.2mm and a wall thickness of 1.6mm are figure 1 In the pipe section 2, select the appropriate Y-type interface 3 and 3' for connection. Fix the connected pipeline on the pump head of the peristaltic pump, connect a Bosch filling needle with an inner diameter of 3.5 mm on the solution outlet side, and place a polystyrene plastic bottle under the filling needle as a receiving container 5 . Bovine serum albumin (BSA) solution (viscosity about 1cp, histidine buffer, pH=6.0, sodium chloride 150mM, BSA concentration 15mg / mL) was selected as the simulated solution.
[0041] Set the filling volume of the peristaltic pump to 20.00mL, the pump s...
Embodiment 3
[0043] The PF6 peristaltic pump of Watson-Marlow Company was used as the metering filling pump 1, and a silicone tube with a length of 150 cm at both ends, an inner diameter of 4.8 mm, and a wall thickness of 1.6 mm was taken as the figure 1 In the pipe section 4 and pipe section 8, two silicone tubes with a length of 20cm, an inner diameter of 3.2mm, and a wall thickness of 1.6mm are figure 1 In the pipe section 2, select the appropriate Y-type interface 3 and 3' for connection. Fix the connected pipeline on the pump head of the peristaltic pump, connect a Bosch filling needle with an inner diameter of 3.5 mm on the solution outlet side, and place a polystyrene plastic bottle under the filling needle as a receiving container 5 . Bovine serum albumin (BSA) solution (viscosity about 1cp, histidine buffer, pH=6.0, sodium chloride 150mM, BSA concentration 15mg / mL) was selected as the simulated solution.
[0044] Set the filling volume of the peristaltic pump to 2.00mL, the pump ...
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