Full-automatic sample pretreatment device and treatment method

A kind of sample pretreatment, fully automatic technology, applied in the field of analytical chemistry, can solve the problem of time-consuming, laborious, complex, large error, etc.

Pending Publication Date: 2021-07-30
苏州艾迪迈医疗科技有限公司
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the offline solid-phase extraction method requires manual extraction, centrifugation, concentration and other operations on the sample before putting it into the chromatograph for sample detection, and needs to replace different reagents. The operation is cumbersome and complicated, time-consuming and labor-intensive, and has large errors , there is a lot of

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  • Full-automatic sample pretreatment device and treatment method
  • Full-automatic sample pretreatment device and treatment method
  • Full-automatic sample pretreatment device and treatment method

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Experimental program
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Embodiment 1

[0041] see Figure 1 to Figure 9, is a specific embodiment of a fully automatic sample pretreatment device. The fully automatic sample pretreatment device includes an installation frame 1, a sampling and processing module 2, a tip box module 3, a reagent tray module 4, a sample tray module 5, a collection module 6, an extraction module 7, a sampling module 8, and an operation control module , generally, the six peripheral surfaces of the installation frame are respectively provided with detachable connection sealing plates to form a shield for the inner space of the installation frame 1 . The tip box module 3, the reagent tray module 4, the sample tray module 5, and the collection module 6 are arranged in the hollow lower part of the installation frame 1, and the collection module 6 is driven by the first transmission mechanism to move along the X-axis direction, so The extraction module 7 includes a filter column tube carrier 71 for shelving the filter column tube, which is ...

Embodiment 2

[0043] The method for sample processing using the fully automatic sample pretreatment device of embodiment 1 comprises the following steps:

[0044] 1) Place the sample tube containing the vancomycin blood sample, the reagent bottle containing the vancomycin extract, the 3ml extraction column, and the collection bottle in the sample tray module, reagent tray module, extraction module, and collection module, respectively, for The sample valve is connected to the infusion pump of the chromatograph, and the operation control module sets the corresponding processing method;

[0045] 2) The sampling and processing module moves to the top of the reagent tray module, the sampling mechanism is inserted into the corresponding reagent bottle, quantitatively absorbs 900ul of the corresponding reagent, and then transfers it to the extraction column corresponding to the extraction module or the collection bottle corresponding to the collection module;

[0046] 3) The sampling and processin...

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Abstract

A full-automatic sample pretreatment device comprises a mounting frame, a gun head box module, a reagent disc module, a sample disc module and a collecting module which are arranged on the lower portion of the inner cavity of the mounting frame, an extraction module is fixedly arranged in the inner cavity of the mounting frame and located above the collecting module, and a sampling and treatment module is located in the inner cavity of the mounting frame and acts in the X-axis direction, the Y-axis direction and the Z-axis direction. The sampling and processing module comprises a sampling mechanism and a positive pressure inflating device, the sample injection module is located in the inner cavity of the mounting frame and acts in the X-axis direction and the Y-axis direction, and a needle tail sample injection valve of a sample injection needle of the sample injection module is used for being connected with an infusion pump of the chromatographic instrument. According to the invention, through mutual cooperation of the modules and combination of off-line solid-phase extraction and on-line solid-phase extraction, full-process automatic operation from sample introduction to result output of a complex sample is realized, the working efficiency is high, and the error is small.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to an automatic sample pretreatment device and a treatment method. Background technique [0002] With the continuous advancement of science and technology, especially the rapid development of life science and clinical diagnosis, the separation and detection of a large number of complex biological samples has become a key part of the analysis work, which accounts for the entire analysis work in terms of workload and technical requirements. A large proportion. [0003] At present, for the detection and analysis of complex matrix samples, pretreatment is generally required, such as offline purification of target analytes in samples using various extraction materials, and then injected into a chromatographic system for analysis, the most common being solid phase extraction. However, the offline solid-phase extraction method requires manual extraction, centrifugation, concentration a...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/20
CPCG01N30/06G01N30/20
Inventor 石功名黄明升罗波
Owner 苏州艾迪迈医疗科技有限公司
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