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Prochlorprazine suppository and preparation method thereof

A technology of prochlorperazine suppository and prochlorperazine, which is applied in the field of prochlorperazine suppository and its preparation, and can solve the problems of inability to meet the clinical needs of patients, easy outflow, and limited bioavailability

Pending Publication Date: 2021-08-03
南京泽恒医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the commercially available prochlorperazine suppository is easy to flow out at rectal temperature, has limited bioavailability, poor efficacy and compliance, and cannot meet the clinical needs of patients.

Method used

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  • Prochlorprazine suppository and preparation method thereof
  • Prochlorprazine suppository and preparation method thereof
  • Prochlorprazine suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prochlorperazine 25mg Polyethylene glycol-chitosan 80mg Glycerin, Paraffin, Propylene Glycol 200mg Semi-synthetic hydrogenated palm kernel oil, semi-synthetic hydrogenated coconut oil 1695mg

[0037] Weigh the raw materials and auxiliary materials according to the prescription, and set aside. Take the suppository base and melt it on a water bath, add glycerin, paraffin, propylene glycol, polyethylene glycol-chitosan and prochlorperazine in turn to melt semi-synthetic hydrogenated palm kernel oil and semi-synthetic hydrogenated coconut oil, disperse evenly, and keep warm. Fill the mold, let it cool, and demould.

Embodiment 2

[0039] Prochlorperazine 25mg Polyethylene glycol-chitosan 100mg Glycerin, Paraffin, Propylene Glycol 200mg Semi-synthetic hydrogenated palm kernel oil, semi-synthetic hydrogenated coconut oil 1675mg

[0040] Weigh the raw materials and auxiliary materials according to the prescription, and set aside. Take the suppository base and melt it on a water bath, add glycerin, paraffin, propylene glycol, polyethylene glycol-chitosan and prochlorperazine in turn to melt semi-synthetic hydrogenated palm kernel oil and semi-synthetic hydrogenated coconut oil, disperse evenly, and keep warm. Fill the mold, let it cool, and demould.

Embodiment 3

[0042] Prochlorperazine 25mg Polyethylene glycol-chitosan 120mg Glycerin, Paraffin, Propylene Glycol 200mg Semi-synthetic hydrogenated palm kernel oil, semi-synthetic hydrogenated coconut oil 1655mg

[0043] Weigh the raw materials and auxiliary materials according to the prescription, and set aside. Take the suppository base and melt it on a water bath, add glycerin, paraffin, propylene glycol, polyethylene glycol-chitosan and prochlorperazine in turn to melt semi-synthetic hydrogenated palm kernel oil and semi-synthetic hydrogenated coconut oil, disperse evenly, and keep warm. Fill the mold, let it cool, and demould.

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Abstract

The invention discloses a prochlorprazine suppository and a preparation method thereof. The prochlorprazine suppository comprises the following components in percentage by mass: 1.25% of prochlorprazine, 3.0-8.0% of polyethylene glycol-chitosan, 8.0-12.0% of additive and 78.0-90.0% of suppository matrix, and each suppository is 2g in weight. Only polyethylene glycol-chitosan is added as an auxiliary material, so that the biological adhesion of the suppository at the rectal temperature can be improved, the degree of freedom during administration can be improved, release of prochlorprazine can be promoted, and the curative effect and compliance of the prochlorprazine suppository are obviously superior to those of an existing commercially available prescription process.

Description

technical field [0001] The invention relates to a suppository and a preparation method thereof, in particular to a prochlorperazine suppository and a preparation method thereof. Background technique [0002] Cancer is one of the diseases that endanger the health of Chinese residents. Its annual morbidity and mortality account for 23.7% and 30% of the global total respectively. Due to population aging, industrialization, urbanization, and lifestyle changes, the incidence and death of cancer in China continue to increase. Chemoradiation and chemotherapy are the main treatments for cancer, but the drugs can cause severe nausea and vomiting, which have a negative impact on the quality of life of patients and even the continuation of treatment. Therefore, antiemetics occupy a very important position in the field of tumor adjuvant therapy. In addition, when pregnant women with nausea and vomiting during pregnancy cannot tolerate oral drugs, in addition to oral and intravenous r...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K47/10A61K47/36A61K47/06A61K47/44A61K47/14A61K31/5415A61P1/08
CPCA61K9/02A61K31/5415A61K47/06A61K47/10A61K47/14A61K47/36A61K47/44A61P1/08
Inventor 徐成葛雨朱亚芳刘馨忆邢珍珍
Owner 南京泽恒医药技术开发有限公司
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