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Cinnamaldehyde nano-emulsion as well as preparation method and application thereof

A nano-emulsion, cinnamaldehyde technology, applied in the directions of emulsion delivery, pharmaceutical formulations, aldehyde active ingredients, etc., can solve the problems of limited antibacterial effect, poor water solubility, and difficulty in storage, and achieves improved water solubility, reduced volatility, and reduced particle size. small diameter effect

Pending Publication Date: 2021-08-03
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, essential oil products are volatile, difficult to preserve, poor in water solubility, and have great restrictions on their antibacterial effects. Solving the above problems is very important for the development of cinnamaldehyde antibacterial products

Method used

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  • Cinnamaldehyde nano-emulsion as well as preparation method and application thereof
  • Cinnamaldehyde nano-emulsion as well as preparation method and application thereof
  • Cinnamaldehyde nano-emulsion as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of emulsifier: 1.2g of Tween-40 and 0.4g of EL-20 were mixed to obtain 1.6g of emulsifier.

[0028] Mix 2.0g of cinnamaldehyde and 1.6g of emulsifier to prepare a mixture of emulsifier and oil, and stir for 12 hours; then add 16.4g of deionized water to the above mixing system, and then cut the mixture at a speed of 8000r / min for 7min High-energy emulsification method to obtain O / W type cinnamaldehyde nanoemulsion.

Embodiment 2

[0030] Preparation of emulsifier: 1.2g of Tween-40 and 0.4g of EL-20 were mixed to obtain 1.6g of emulsifier.

[0031] Mix 2.0g of cinnamaldehyde and 1.6g of emulsifier to prepare a mixture of emulsifier and oil, and stir for 12 hours; then add 16.4g of deionized water into the above mixing system, and then cut the mixture at a speed of 10000r / min for 7min High-energy emulsification method to obtain O / W type cinnamaldehyde nanoemulsion.

Embodiment 3

[0033] Preparation of emulsifier: 1.2g of Tween-40 and 0.4g of EL-20 were mixed to obtain 1.6g of emulsifier.

[0034] Mix 2.0 g of cinnamaldehyde and 1.6 g of emulsifier to prepare a mixture of emulsifier and oil, and stir for 12 hours; then add 16.4 g of deionized water to the above mixing system, and then cut the mixture at a speed of 12000 r / min for 7 min High-energy emulsification method to obtain O / W type cinnamaldehyde nanoemulsion.

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Abstract

The invention belongs to the technical field of preparation of bacteriostatic agent nano-emulsion, and relates to cinnamyl aldehyde nano-emulsion as well as a preparation method and application thereof. The preparation method comprises the following steps: uniformly mixing cinnamyl aldehyde and an emulsifier, adding deionized water, and carrying out high-speed shearing to obtain the cinnamyl aldehyde nano-emulsion. The cinnamyl aldehyde nano-emulsion prepared by the method disclosed by the invention is in a stable O / W type, and the sterilization rate of the nano-emulsion on gram-negative bacteria (escherichia coli) reaches 99%.

Description

technical field [0001] The invention belongs to the technical field of preparation of bacteriostatic agent nanoemulsion, and relates to a cinnamaldehyde nanoemulsion, a preparation method and application thereof. Background technique [0002] Escherichia coli and Staphylococcus aureus are common pathogenic bacteria in people's daily life. Escherichia coli is the representative of Gram-negative bacteria, and some Escherichia coli can cause severe diarrhea, meningitis, intestinal infection, urinary tract infection, sepsis, etc., which seriously endanger people's health. Staphylococcus aureus is a representative of Gram-positive bacteria. Staphylococcus aureus is more common in spring and summer, and is a common pathogenic bacterium of human suppurative infection. [0003] For the prevention and treatment of such bacteria, the most widely used drugs are antibiotics, such as penicillins, cephalosporins, aminoglycosides, sulfonamides and the like. The widespread use of antibio...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/11A61K36/534A61K47/26A61K47/44A61P31/04
CPCA61K31/11A61K36/534A61K9/1075A61K47/26A61K47/44A61P31/04Y02A50/30
Inventor 刘岐颛孙相勋王子旋高园张梓洛
Owner YANGZHOU UNIV