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A kind of hemostatic repair material and preparation method thereof

A technology for repairing materials and composite materials, applied in the field of hemostatic repairing materials, can solve the problems of complicated preparation process, difficult to popularize, thromboembolism, etc., and achieves that the preparation method is simple and easy to operate, is beneficial to large-scale industrial production, and has strong liquid absorption. Effect

Active Publication Date: 2022-04-08
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when applied directly to wounds, the hemostatic effect of montmorillonite particles is very strong, and blood clots will quickly form locally, which will be difficult to degrade after entering the body with blood, and the montmorillonite particles remaining in the body may cause thrombus Formation of embolic complications, thus limiting its practical application
Sun Rongzhan used shells and chitosan as raw materials to prepare the shell powder / chitosan composite hemostatic material through supercritical fluid technology, and obtained a good hemostatic effect, but due to its complicated preparation process, it is difficult to be popularized

Method used

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  • A kind of hemostatic repair material and preparation method thereof
  • A kind of hemostatic repair material and preparation method thereof
  • A kind of hemostatic repair material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0035] (2) Dissolve 1.584g of ammonium hydrogen phosphate in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add montmorillonite according to the ratio of 1:1 of montmorillonite:shell powder, and then add 0.100g of electrical Stone powder, adjust pH=8 with ammonia water, stir at room temperature for 1 hour, then sonicate for 0.5 hour, and stir again for 1 hour;

[0036] (3) Pour the above mixture into a 100ml hydrothermal kettle and react at 180°C for 12h, and obtain the shell / montmorillonite composite material after suction filtration, washing and drying;

[0037] (4) get 2.000g chitosan and be dissolved in 100ml1% acetic a...

Embodiment 2

[0043] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0044] (2) Dissolve 1.584g of ammonium hydrogen phosphate in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add montmorillonite at a ratio of 1:2 of montmorillonite:shell powder, and then add 0.100g of electrical Stone powder, adjust pH=8 with ammonia water, stir at room temperature for 1 hour, then sonicate for 0.5 hour, and stir again for 1 hour;

[0045] (3) Pour the above mixture into a 100ml hydrothermal kettle and react at 180°C for 12h, and obtain the shell / montmorillonite composite material after suction filtration, washing and drying;

[0046] (4) get 2.000g chitosan and be dissolved in 100ml1% acetic acid solution...

Embodiment 3

[0049] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0050] (2) Dissolve 1.584g of ammonium hydrogen phosphate in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add montmorillonite according to the ratio of montmorillonite: shell powder of 1:1, and then add 0.200g of electrical Stone powder, adjust pH=8 with ammonia water, stir at room temperature for 1 hour, then sonicate for 0.5 hour, and stir again for 1 hour;

[0051] (3) Pour the above mixture into a 100ml hydrothermal kettle and react at 180°C for 12h, and obtain the shell / montmorillonite composite material after suction filtration, washing and drying;

[0052] (4) get 2.000g chitosan and be dissolved in 100ml1% acetic ...

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Abstract

The invention discloses a hemostatic repair material and a preparation method thereof. In the preparation method, shells and montmorillonite are used as main raw materials, and ammonium hydrogen phosphate is used as a phosphorus source for hydrothermal reaction. The tourmaline attracts the nucleation and growth of hydroxyapatite and the aggregation of montmorillonite sheets on the surface of the tourmaline. The shell / montmorillonite composite material without free montmorillonite, and then the shell / montmorillonite composite material is embedded in the chitosan sponge matrix through a freeze-drying process to prepare the shell / montmorillonite hemostatic repair material. The restoration material can achieve a coagulation time of about 130-140s, the antibacterial rate is over 85%, and the hemolysis rate is less than 5%, which meets the requirements of the national standard for biological safety of biological materials.

Description

technical field [0001] The invention relates to the field of hemostatic repair materials, in particular to a hemostatic repair material and a preparation method thereof. Background technique [0002] The life safety problem caused by traumatic hemorrhage has become a worldwide problem. In an emergency, it is very important to be able to achieve rapid hemostasis, and the hemostatic mechanism of the human body is a relatively complex and time-consuming process. In some serious traumas, it is difficult to complete the hemostasis only by the human body itself To stop bleeding, it is necessary to apply external intervention to the wound to achieve the purpose of rapid hemostasis. Therefore, the development of high-efficiency hemostatic materials has become the key to rapid hemostasis and reduction of bleeding mortality. However, there are very few hemostatic agents that meet the requirements of safety, effectiveness, and economy at the same time. Therefore, solid waste resourc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/40A61L15/42A61L15/44A61L15/46
CPCA61L15/28A61L15/18A61L15/40A61L15/44A61L15/46A61L15/425A61L2400/04A61L2300/30A61L2300/404A61L2300/418
Inventor 孟军平郭涛梁金生
Owner HEBEI UNIV OF TECH