Unlock instant, AI-driven research and patent intelligence for your innovation.

Microsphere preparation system capable of simultaneously adjusting particle size and release of microspheres

A preparation system and microsphere particle size technology, which is applied in microsphere preparation, microcapsule preparation, transportation and packaging, etc., can solve the problems of long time for theoretical drying effect, unfavorable pilot test scale-up, prolonging production cycle, etc., and achieve particle size The diameter adjustment range is stable, the control parameters are few, and the effect of shortening the construction period

Active Publication Date: 2021-08-10
ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this control method has many parameters, which increases the index of central control, and takes a long time to achieve the theoretical drying effect, which prolongs the production cycle and is not conducive to the scale-up of the pilot test. Improve this

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microsphere preparation system capable of simultaneously adjusting particle size and release of microspheres
  • Microsphere preparation system capable of simultaneously adjusting particle size and release of microspheres
  • Microsphere preparation system capable of simultaneously adjusting particle size and release of microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Such as figure 1 A microsphere preparation system that can simultaneously adjust the particle size and release of microspheres is shown, including a water phase tank 1, an oil phase tank 2, a static mixer 3, a regulating pipeline 4 and a hardening liquid tank 5, and the water phase tank and The oil phase tank is connected to the Y-type tee 9 through the water phase delivery pipeline 6 and the oil phase delivery pipeline 7 respectively, and the Y-type tee is further connected to the feed end of the static mixer (SV type), the water phase delivery pipeline and the oil phase Metering pumps 8 are installed on the phase conveying pipelines, one end of the regulating pipeline is connected to the discharge end of the static mixer, and the other end is connected to the hardening liquid tank.

[0029] The inner diameter of the regulating pipeline is 1 / 8 of the inner diameter of the static mixer. The length of the regulating pipeline is 3m. The material of the regulating pipeli...

Embodiment 2

[0031] Such as figure 1 A microsphere preparation system that can simultaneously adjust the particle size and release of microspheres is shown, including a water phase tank 1, an oil phase tank 2, a static mixer 3, a regulating pipeline 4 and a hardening liquid tank 5, and the water phase tank and The oil phase tank is connected to the Y-type tee 9 through the water phase delivery pipeline 6 and the oil phase delivery pipeline 7 respectively, and the Y-type tee is further connected to the feed end of the static mixer (SL type), the water phase delivery pipeline and the oil phase Metering pumps 8 are installed on the phase conveying pipelines, one end of the regulating pipeline is connected to the discharge end of the static mixer, and the other end is connected to the hardening liquid tank.

[0032] The inner diameter of the regulating pipeline is 3 / 4 of the inner diameter of the static mixer. The length of the regulating pipeline is 0.5m. The material of the regulating pipe...

Embodiment 3

[0034] Such as figure 1 A microsphere preparation system that can simultaneously adjust the particle size and release of microspheres is shown, including a water phase tank 1, an oil phase tank 2, a static mixer 3, a regulating pipeline 4 and a hardening liquid tank 5, and the water phase tank and The oil phase tank is connected to the Y-type tee 9 through the water phase delivery pipeline 6 and the oil phase delivery pipeline 7 respectively, and the Y-type tee is further connected to the feed end of the static mixer (SK type), the water phase delivery pipeline and the oil phase Metering pumps 8 are installed on the phase conveying pipelines, one end of the regulating pipeline is connected to the discharge end of the static mixer, and the other end is connected to the hardening liquid tank.

[0035]The inner diameter of the regulating pipeline is 3 / 16 of the inner diameter of the static mixer. The length of the regulating pipeline is 2m. The material of the regulating pipeli...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a microsphere preparation system capable of simultaneously adjusting the particle size and release of microspheres. The system comprises a water phase tank (1), an oil phase tank (2), a static mixer (3), an adjusting pipeline (4) and a hardening liquid tank (5), the water phase tank and the oil phase tank are respectively connected to the feed end of the static mixer through a water phase conveying pipeline (6) and an oil phase conveying pipeline (7); and metering pumps (8) are arranged on the water phase conveying pipeline and the oil phase conveying pipeline, one end of the adjusting pipeline is connected with the discharging end of the static mixer, the other end of the adjusting pipeline is connected to the hardening liquid tank, and the inner diameter of the adjusting pipeline is smaller than that of the static mixer. The system is few in control parameters, easy to implement, low in manufacturing cost, capable of effectively reducing the difference caused by small test to amplification, suitable for transformation of a newly-added microsphere production line, capable of effectively reducing the cost and shortening the construction period and capable of providing a new solution for process equipment reaching the limit value, and only one section of pipeline needs to be replaced.

Description

technical field [0001] The invention relates to the technical field of microsphere production, in particular to a microsphere preparation system capable of simultaneously adjusting the particle size and release of microspheres. Background technique [0002] Among the preparation methods of sustained-release microspheres for injection, the emulsification-solvent evaporation method is more mature. First, the oil phase needs to be emulsified. The common emulsification methods include stirrer, ultrasonic instrument, static mixer, high-speed shearer, etc. Jansen (Johnson) company developed long-acting antipsychotic drug risperidone long-acting injection (trade name: Hengde) in August, 2002, and this dosage form has adopted the Medisorb technology of Alkermes company, uses static mixer as emulsification equipment, its The emulsification process has high continuity, and the emulsification mainly depends on the turbulence effect generated when the mixed fluid flows through the inner...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/04B01F5/06
CPCB01J13/02B01J13/04B01F25/431
Inventor 杜保国蒋朝军颜蕾于崆峒刘喜明李海杰
Owner ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD