Drug-loaded degradable absorbable medical suture thread and preparation method thereof

Abstract

The invention discloses a drug-loaded degradable and absorbable medical suture thread and a preparation method thereof. The suture thread uses a polylactic acid-based material as a silk thread matrix, and the silk thread matrix, an intermediate drug-loading layer and an outer lubricating layer are formed by a drug-loaded protein hydrogel. The suture is prepared by bonding into one, and the suture is prepared through a special synthesis process; the obtained suture can effectively control the degradation and absorption cycle of human skin; the innovative combination of the polylactic acid silk matrix and the drug-loaded coating layer can effectively improve the performance of the suture. Antibacterial, hemostatic and anti-inflammatory effects; the outer lubricating layer can effectively improve the lubricity of the suture, reduce the pain of patients during the operation and improve the operability of the operation. The raw materials of the suture thread can be degraded and absorbed, and have good biocompatibility and physiological activity. The preparation method is simple in process, convenient in operation and wide in raw material sources, and has a good application prospect.

Description

technical field [0001] The present application relates to medical sutures in the medical field, in particular to a drug-loaded degradable and absorbable medical suture and a preparation method thereof. Background technique [0002] Medical surgical suture is a sterile thread used for wound healing, tissue ligation and tissue fixation, which plays an important role in the initial healing of wounds. However, the current sutures on the market have the following problems: 1. The direct use of drugs brings disadvantages such as poor selectivity, large toxic and side effects, fast metabolism, short half-life, and poor stability; 2. Ordinary silk threads cannot be automatically degraded, and are only used for the skin outside the wound. 3. The existing non-biodegradable sutures have poor degradation effect, poor compatibility, can not be completely absorbed, and easily leave suture scars; 4. People have higher and higher requirements for the beauty and health of sutured wound reco...

AI Technical Summary

Problems solved by technology

However, the sutures currently on the market have the following problems: 1. The direct use of drugs brings disadvantages such as poor selectivity, large toxic and side effects, fast metabolism, short half-life, and poor stability; 2. Ordinary silk threads cannot be automatically degraded and are only used on the external skin of the wound. 3. The existing non-biodegradable sutures have poor degradation effect, poor compatibility, cannot be completely absorbed, and easily leave suture scars; 4. People have higher and higher requirements for the aesthetics and health of sutured wound recovery

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