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Dextran microsphere, and preparation method and application thereof

A technology of dextran and microspheres, applied in application, prosthesis, surgery, etc., can solve problems such as suboptimal treatment, suboptimal tumor and cancer treatment, etc.

Inactive Publication Date: 2021-08-27
宁波绿糖生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the inadequacy of traditional clinical therapy in the process of treating tumors, cancers and other intractable diseases, this has caused certain limitations and deficiencies in the clinical treatment of tumors, cancers and other intractable diseases, especially for some difficult and miscellaneous diseases. The treatment of tumors, cancers, etc. is still not ideal. The purpose of the present invention is to provide a dextran microsphere and its preparation method and application
Therefore, through the development of dextran microspheres, the present invention can not only solve the problem that the treatment of some refractory tumors and cancers is not ideal, but also meet the needs of related fields.

Method used

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  • Dextran microsphere, and preparation method and application thereof
  • Dextran microsphere, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A dextran microsphere, comprising the following raw materials by weight fraction: 1.6 parts of modified dextran, 50 parts of methyl silicone oil and 1 part of nitrogen nitrogen methylenebisacrylamide.

[0035] A preparation method of dextran microspheres, comprising the following steps:

[0036] S1. Prepare various raw materials according to the formula, and conduct raw material screening;

[0037] S2. Under nitrogen atmosphere, dextran and succinic anhydride are reacted and modified in dimethyl sulfoxide;

[0038] S3. Vacuum drying the modified dextran;

[0039] S4. Slowly add the modified dextran into the methyl silicone oil dropwise, then add nitrogen nitrogen methylenebisacrylamide into it, and carry out the reaction together. The reaction time is 20 hours, the temperature is 75°C, and then Stand still for 20h;

[0040] S5. After the reaction is over, discard the supernatant, take the precipitate, and wash it twice with absolute ethanol;

[0041] S6. Then vacuum...

Embodiment 2

[0043] A dextran microsphere comprises the following raw materials by weight fraction: 2.5 parts of modified dextran, 60 parts of liquid paraffin and 1.5 parts of polypropylene vinyl maleic anhydride grafted with β-cyclodextrin.

[0044] S1. Prepare various raw materials according to the formula, and conduct raw material screening;

[0045] S2. Dissolving the crosslinking agent and β-cyclodextrin in dry DMF for reaction, the reaction time is 7 hours, and the temperature is 80°C;

[0046] S3. DMF is then evaporated to obtain polypropylene vinyl maleic anhydride grafted with β-cyclodextrin;

[0047] S4. Under nitrogen atmosphere, dextran and succinic anhydride are reacted and modified in dimethyl sulfoxide;

[0048] S5. Vacuum drying the modified dextran;

[0049] S6. Slowly add the partially modified dextran into the oil phase solvent, and react with the oil phase solvent for a period of time, the reaction time is 24 hours, the temperature is 85 ° C, and then stand still for ...

Embodiment 3

[0053] A dextran microsphere comprises the following raw materials by weight fraction: 2.8 parts of modified dextran, 75 parts of methyl silicone oil and 1.2 parts of polypropylene vinyl maleic anhydride grafted with β-cyclodextrin.

[0054] A preparation method of dextran microspheres, comprising the following steps:

[0055] S1. Prepare various raw materials according to the formula, and conduct raw material screening;

[0056] S2. Dissolving the cross-linking agent and β-cyclodextrin in dry DMF for reaction, the reaction time is 8.5 hours, and the temperature is 85°C;

[0057]S3. DMF is then evaporated to obtain polypropylene vinyl maleic anhydride grafted with β-cyclodextrin;

[0058] S4. Under nitrogen atmosphere, dextran and succinic anhydride are reacted and modified in dimethyl sulfoxide;

[0059] S5. Vacuum drying the modified dextran;

[0060] S6. Dissolving the partially modified dextran in the oil phase solvent, and reacting with the oil phase solvent for a peri...

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Abstract

The invention particularly discloses a dextran microsphere, and a preparation method and application thereof. The dextran microsphere is prepared from, by weight,1.5 to 3.2 parts of water phase solvent, 45 to 85 parts of oil phase solvent and 0.8 to 1.5 parts of cross-linking agent. The preparation method of the dextran microspheres comprises the following steps: S1, preparing various raw materials according to a formula, and screening the raw materials; S2, in a nitrogen atmosphere, carrying out reaction modification on dextran and succinic anhydride in dimethyl sulfoxide; S3, performing vacuum drying on each modified dextran; S4, dissolving part of modified dextran in an oil phase solvent, reacting with a cross-linking agent for 18-36 h at 70-95 DEG C, and standing for 18-30 h after the reaction is completed; S5, after the reaction is finished, discarding supernate, taking precipitate, and washing with absolute ethyl alcohol for 1-3 times; and S6, carrying out vacuum drying on the precipitate to obtain the product.

Description

technical field [0001] The invention relates to the technical field of material preparation, in particular to a dextran microsphere and its preparation method and application. Background technique [0002] In recent years, due to the intensification of social competition and the increasing pressure of life, people's body and mind are in a state of high pressure for a long time. The illegal addition and abuse of additives in food and the prevalence of fast food culture all damage the nutrients and vitamins in food, leading to the lack of various nutrients and vitamins in people, which in turn harms people's health and causes As a result, the incidence of diseases such as tumors and cancers has greatly increased, and there is a trend of younger age. [0003] Natural polymer magnetic microspheres are a new type of multifunctional material developed in recent years; moreover, natural polymer materials have been widely used in biochemical engineering, cytology, and biology becau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61L27/20A61L27/50
CPCA61L24/08A61L24/001A61L27/20A61L27/50A61L2430/36C08L5/02C08L51/02
Inventor 王晓娟
Owner 宁波绿糖生物科技有限公司