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Double-wheel-shaped nanoparticles and preparation method thereof

A nano-particle and double-wheel technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of complex preparation process, low drug loading, poor drug safety, etc. Achieve the effects of enhancing sensitivity, enhancing immunogenicity, and enhancing immune effect

Active Publication Date: 2021-08-31
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on this, it is necessary to provide a double-wheel-shaped nanoparticle and its preparation method for the problems of poor safety, low drug loading and complicated preparation process of traditional nanocarrier drugs.

Method used

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  • Double-wheel-shaped nanoparticles and preparation method thereof
  • Double-wheel-shaped nanoparticles and preparation method thereof
  • Double-wheel-shaped nanoparticles and preparation method thereof

Examples

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preparation example Construction

[0055] The embodiment of the present invention also provides a preparation method of the biwheel-shaped nanoparticles, comprising the following steps:

[0056] a. Linking the antigen to the environment-responsive linker molecule to form the first product;

[0057] b. reacting the first product with the hydrophilic drug molecule to obtain a second product;

[0058] c. reacting said second product with said hydrophobic adjuvant molecule.

[0059] The linking reaction between the hydrophobic adjuvant molecule, the antigen, the environment-responsive linking molecule and the hydrophilic drug molecule may be an ester reaction between a hydroxyl group and a carboxylic acid, an amidation reaction, etc., which are not limited here. An appropriate type of reaction can be selected according to the type of groups of each molecule to be attached.

[0060] The present invention forms the double-wheel-shaped nanoparticles in an integrated self-assembly manner, and the reaction time and te...

Embodiment

[0070] The specific steps include: mixing PSMA-MMP-9 polypeptide molecule (ESWTKKSPSPEFSGMGPQGIAGQR) with 1,2-dichloroethane and N-hydroxysuccinimide according to a certain mass ratio, stirring and reacting at room temperature for 2 hours, and then adding albinohydrochloride Mycin, its mass ratio to polypeptide molecules is 0.1-1:1, stirred at room temperature for 24 hours, dialyzed with a dialysis bag, collected substances with larger molecular weights, and freeze-dried to obtain PSMA-MMP-9-DOX; the monophospholipid Acyl A and N,N'-carbonyldiimidazole were mixed at a mass ratio of 1:1, stirred at room temperature for 2 hours, then PSMA-MMP-9-DOX with 5 times the mass of monophosphatidyl A was added, mixed, stirred at room temperature for 12 hours, A dialysis bag is used for dialysis to collect substances with higher molecular weights to obtain MPLA-PSMA-MMP-9-DOX nanoparticles. Such as Figure 2A , Figure 2B As shown, the particle size of MPMD NPs (MPLA-PSMA-MMP-9-DOX nano...

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Abstract

The invention discloses double-wheel-shaped nanoparticles. Each double-wheel-shaped nanoparticle is of a spherical structure formed by self-assembly of monomer molecules, and the monomer molecules comprise hydrophobic adjuvant molecules, antigens, environment-responsive connecting molecules and hydrophilic drug molecules which are connected in sequence; the hydrophobic adjuvant molecules are distributed on the inner side of the spherical structure; and the hydrophilic drug molecules are distributed on the outer side of the spherical structure. The invention discloses a preparation method of the double-wheel-shaped nanoparticles.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a double wheel-shaped nano particle and a preparation method thereof. Background technique [0002] Tumor is one of the important problems affecting human health and life at present. A single treatment method often fails to achieve a good therapeutic effect. In order to prolong the survival period of cancer patients and improve their quality of life, combined treatment has become a trend in tumor treatment. However, at present, systemic drug administration is mostly used in tumor treatment, and the systemic side effects are relatively large. Nanocarriers have unique advantages in drug delivery, which can not only increase the local accumulation of drugs in tumors, enhance the therapeutic effect of drugs, but also reduce systemic adverse reactions. In particular, in terms of combined tumor therapy, nano-medicine can achieve synergistic therapeutic effects between different ther...

Claims

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Application Information

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IPC IPC(8): A61K39/385A61K39/00A61K39/39A61K9/51A61K31/704A61K47/42A61K47/65A61P35/00A61P37/04
CPCA61K39/385A61K39/001195A61K39/39A61K47/65A61K31/704A61K9/5169A61P35/00A61P37/04A61K2039/575A61K2039/6031A61K2300/00
Inventor 刘兰霞冷希岗马兵邓博
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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