Force spectroscopy analysis method and analysis device based on nanopore sequencing
An analysis device and nanopore technology, which is applied in the field of force spectroscopy analysis methods and analysis devices, can solve the problem of not having the ability to describe the microscopic characteristics of the internal structure of nanoporin in a fine-grained manner, and achieve the effect of high sensitivity
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[0033] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings through specific embodiments.
[0034] The invention provides a differential force spectrum analysis method, which aims to obtain the force spectrum characteristics of the interaction between a single base and a protein molecule by analyzing the related information of nanopore sequencing, so that the related microphysical mechanism can be quantitatively analyzed.
[0035] figure 1 A schematic diagram showing the principle of nanopore sequencing is shown. During a nanopore sequencing operation, the DNA duplex binds to and uncoils with nanoporins embedded in biological membranes under the action of molecular motors such as helicases, and then moves across the nanopore due to a voltage bias. The nanopore has a sequencing-sensitive site for recording the ion c...
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