Method for detecting dissolution rate of tannic acid particles
A detection method, the technology of tannic acid, applied in the direction of color/spectral characteristic measurement, etc., can solve the problems affecting the absorption and palatability of nutrients, the dissolution of tannic acid and the influence of pharmacological effects, and the destruction of tannic acid, so as to ensure the clinical Safe to use, ensure controllable production process, stable curative effect and exact effect
Inactive Publication Date: 2021-09-03
珠海天凯生物科技有限公司
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Problems solved by technology
[0003] However, there are still many problems in the application of tannic acid in feed: 1. Tannic acid is easily damaged by environmental factors such as high temperature and high humidity; 2. Tannic acid is acidic, and it is easily neutralized by alkaline substances when directly applied in feed; 3. The active finished product of tannic acid is absorbed in the stomach and the front part of the duodenum, which affects the absorption of other nutrients and palatability, etc.
Therefore, tannic acid cannot be directly used in feed, and it needs to be made into a slow-release preparation to avoid the above problems
The preparation process of sustained-release preparations will have a serious impact on the dissolution and pharmacological effects of tannic acid in the body: if the dissolution is too slow, the drug cannot reach the blood concentration and produce pharmacological effects; if the dissolution is too fast, the sustained-release effect cannot be achieved
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[0022] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.
[0023] A method for detecting the dissolution rate of tannic acid granules, comprising the following specific steps:
[0024] Take by weighing tannic acid granules (approximately equivalent to tannic acid 130mg), according to Chinese Pharmacopoeia 2020 edition general rule 0931 first method for dissolution and release determination, with concentration being 750ml hydrochloric acid solution of 0.1mol / L as dissolution medium, rotating speed 50 revolutions per minute, operate according to the law, after 1.5h, take a sample of 10ml, filter, take 1ml of the filtrate, put it in a 10ml measuring bottle, dilute with water to the mark, shake well, filter as the test solution; according to ultraviolet spectrophotometry , measure the absorbance at a wavelength of 274nm; after sampling, add 250ml of sodium phosphate solution at a temperature of 3...
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Abstract
The invention discloses a method for detecting the dissolution rate of tannic acid particles, and belongs to the technical field of feed additives. Scientific experiment research determines that an ultraviolet spectrophotometer is adopted to measure the absorbance of a test solution and a reference solution at the wavelength of 274 nm, and an external standard method is adopted to calculate the dissolution rate of tannic acid at different time. The detection method fills the blank of quality control of the tannic acid particles in the feed, is suitable for being used as a quality control method of the dissolution rate of the tannic acid particles, and is beneficial to establishing a quality control standard of the tannic acid particles.
Description
technical field [0001] The invention relates to the technical field of feed additives, in particular to a method for detecting the dissolution rate of tannic acid granules. Background technique [0002] In the process of animal feeding, long-term use of antibiotics is prone to problems such as drug resistance and drug residues, which will affect food safety. Tannic acid, as an antibacterial substance derived from plants, is more and more widely used in feed. Tannic acid is a polyphenolic compound with strong biological characteristics and pharmacological activity, and is a secondary substance produced in the process of plant metabolism. Studies have shown that tannic acid has antibacterial, anti-oxidant, anti-inflammatory effects on poultry animals, improving the intestinal micro-ecological environment and promoting animal growth, so the application of tannic acid can effectively reduce the amount of antibiotics. [0003] However, there are still many problems in the appli...
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Login to View More IPC IPC(8): G01N21/33
CPCG01N21/33
Inventor 张晓明麦耀权周序诚谭垚婷黄家俊沈黎江
Owner 珠海天凯生物科技有限公司