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Composition for preventing or treating inflammation, allergies and asthma, containing veronicastrum sibiricum l. pennell as active ingredient, and use thereof

A technology of herbal clematis and anaphylaxis, applied in the field of composition for prevention or treatment of inflammation, anaphylaxis and asthma, capable of solving undisclosed or taught problems

Pending Publication Date: 2021-09-03
KT&G CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, none of the above documents discloses or teaches a therapeutic agent for inflammation, allergic reaction, and asthma disease containing the herbal clematis (Veronicastrum sibiricum L. Pennell; Veronicastrum: Ascites) extract as an active ingredient

Method used

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  • Composition for preventing or treating inflammation, allergies and asthma, containing veronicastrum sibiricum l. pennell as active ingredient, and use thereof
  • Composition for preventing or treating inflammation, allergies and asthma, containing veronicastrum sibiricum l. pennell as active ingredient, and use thereof
  • Composition for preventing or treating inflammation, allergies and asthma, containing veronicastrum sibiricum l. pennell as active ingredient, and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: the preparation of herbal Clematis clematis crude extract

[0072] 1-1: Preparation of Methanol Extract of Herb Clematis clematis

[0073] 1.16 kg of dried and pulverized herb clematis (Veronicastrum sibiricum L. Pennell; Veronicastrum: Ascites genus, cultivation (Ansan, Gyeonggi-do)) whole plant was dispersed in methanol, 4 L each, repeated 3 times, at room temperature Using an ultrasonic extractor (5510R-DTH, Bransonic), exposed to ultrasonic waves at 60° C. for 2 hours to prepare the methanolic extract of the herb Clematis clematis. Thereafter, it was concentrated under reduced pressure at 40° C. with a reduced-pressure concentrator (EYELA, N-2100, Japan (JAPAN)), and completely dried by freeze-drying with a freeze-dryer (FDU-2100, Lab corporation), thereby obtaining 120.68 g of methanol extract of the herb Clematis clematis in dry state (hereinafter referred to as "VSM") was stored at -20°C.

[0074] 1-2. Preparation of water extract of herbal Cle...

Embodiment 2

[0084] Embodiment 2: the preparation of herbal Clematis nonpolar solvent-soluble extract

[0085] 120.68 g of the methanolic extract of the herb Clematis clematis of Example 1 above was dissolved in water. And use 4L of normal hexane to classify, after taking the aqueous solution layer, classify it again with 4L of ethyl acetate, collect the ethyl acetate solution layer of Clematis clematis, to prepare the ethyl acetate extract of Clematis cloverleaf. Thereafter, it was concentrated under reduced pressure at 40° C. with a vacuum concentrator (EYELA, N-2100, Japan (JAPAN)), and after complete drying was achieved by freeze drying with a freeze dryer (FDU-2100, Lab corporation), to obtain 12.6 g of the herbal clematis ethyl acetate soluble fraction (hereinafter referred to as "VSEA") in dry state were stored at -20°C.

experiment example 1

[0086] Experimental example 1: Leukotriene (leukotriene) production inhibitory evaluation

[0087] In order to confirm the leukotriene (leukotriene) production inhibitory activity of the above-mentioned preparation example sample, by adopting the method described in the following documents to carry out experiment (Goulet, J.L., et al., J Immunol, 164 (9), 4899-4907 (2000 ).

[0088] 1-1. Experimental method

[0089] For confirming the inhibitory action of the 5-lipoxygenase (lipoxygenase) of above-mentioned embodiment sample, adopt the method of literature (Goulet, J.L., et al., J Immunol, 164 (9), 4899-4907 (2000) etc., Quantitative leukotriene (leukotriene), its result is shown in table 2.In table 2, the final concentration in the culture medium of the montelukast (montelukast, PHR1603, Sigma-Aldrich) as positive control group is processed as 100 μ M , the remaining test drugs, that is, the final concentration of preparation examples 1 to 2 is 10 to 50 μg / ml, and the fin...

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PUM

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Abstract

The present invention relates to a composition for preventing or treating inflammation, allergies and asthma, containing Veronicastrum sibiricum L. Pennell (genus Veronicastrum) extract as an active ingredient. It has been ascertained, through various animal experiments, that a Veronicastrum sibiricum L. Pennell extract according to the present invention exhibits excellent anti-inflammatory, anti-allergic and asthma inhibitory activity, thereby being useful as a pharmaceutical composition, a functional health food or a supplementary health food for preventing or treating inflammation, allergies and asthma.

Description

technical field [0001] The present invention relates to a composition for the prevention or treatment of inflammation, allergic reaction and asthma containing the herb Clematis clematis extract as an active ingredient and its use. Background technique [0002] In general, an inflammatory response is a defense reaction process of an organism, that is, a process in which the organism attempts to repair and regenerate the damaged area when an invasion causing some organic change is applied to the cells or tissues of the organism. Therefore, such a series of reactions include local blood vessels, various tissue cells in body fluids, and immune-related cells. Recently, with the development of molecular biology, attempts are being made to understand inflammatory diseases at the molecular level of cytokines, and factors affecting these diseases have been identified one by one. [0003] Anaphylaxis can be classified into four types according to the type of reaction: types I, II, II...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61P29/00A61P37/08A61P11/06A23L33/105
CPCA23L33/105A61P29/00A61P11/06A61K36/68A61P37/08A23L33/40A23L2/52A23V2002/00A61K9/0019A61K9/0056A61K9/0095A61K9/1611A61K9/1623A61K9/2013A61K9/2018A61K9/2059A61K9/4858A61K9/4866A61K31/07A61K31/197A61K31/198A61K31/355A61K31/375A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/714A61K33/00A61K33/06A61K33/10A61K33/26A61K33/30A61K47/02A61K47/12A61K47/26A61K47/46A61K2236/331A61K2236/333A61K2236/35
Inventor 慎汉縡诸炳权李文镛郭孝民赵成一金荣信李东勋金铁宁
Owner KT&G CO LTD
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