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Preparation method of traditional Chinese medicine composition for resisting myocardial ischemia

An anti-myocardial ischemia and composition technology is applied in the field of preparation of new drug formulations, and achieves the effects of simple preparation method, wide source of raw materials, and improvement of myocardial necrosis area

Active Publication Date: 2021-09-07
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current treatment for ischemic heart disease mostly uses chemical drugs, such as nitrates, statins, anti-platelet agents, etc. Currently, there is no Chinese medicine with definite curative effect for clinical treatment

Method used

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  • Preparation method of traditional Chinese medicine composition for resisting myocardial ischemia
  • Preparation method of traditional Chinese medicine composition for resisting myocardial ischemia
  • Preparation method of traditional Chinese medicine composition for resisting myocardial ischemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Chinese medicine composition preparation process screening embodiment:

[0023] 1. Extraction process

[0024] 1) Weigh raw materials

[0025] Take the following raw materials by weight according to the prescription quantity: 15 parts of jujube, 10 parts of salvia miltiorrhiza, 10 parts of sandalwood, 10 parts of myrobalan, 10 parts of kapok;

[0026] (2) water extraction

[0027] Add raw materials to water, heat reflux to extract; filter, take water extract for later use;

[0028] (3) Alcohol precipitation

[0029] Concentrate the extract to a relative density of 1.1-1.2, add ethanol to a certain concentration, precipitate, take the filtrate, concentrate to remove ethanol in the solvent, and obtain the SXK aqueous solution of the anti-myocardial ischemia Chinese medicine composition.

[0030] 2. Optimization of extraction process

[0031] 1 Instruments and materials

[0032] 1.1 Instruments High-performance liquid chromatography (Dinex Ultimate 3000, Diane Instru...

Embodiment 2

[0062] Example of product preparation

[0063] 1) Weigh raw materials

[0064] Take the following raw materials by weight according to the prescription quantity: 15 parts of jujube, 10 parts of salvia miltiorrhiza, 10 parts of sandalwood, 10 parts of myrobalan, 10 parts of kapok;

[0065] (2) water extraction

[0066] Add the raw material to 12 times the weight of water, heat reflux extraction 3 times, each time for 1.5h; filter, combine the extracts, and set aside;

[0067] (3) Alcohol precipitation

[0068] After combining the extracts, concentrate the extracts to a relative density of 1.1-1.2, add ethanol until the ethanol content in the solution is 85%, precipitate, and take the filtrate to obtain the water extract of the Chinese medicine composition of the present invention.

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine composition for resisting myocardial ischemia. The preparation method comprises the following steps of: (1) weighing raw materials: weighing the following raw materials in parts by weight: 15 parts of fructus choerospondiatis, 10 parts of radix salviae miltiorrhizae, 10 parts of sandalwood, 10 parts of fructus chebulae and 10 parts of common bombax flower; (2) performing water extraction: adding water into the raw materials, performing hot reflux extraction, filtering, and taking a water extract for later use; and (3) performing alcohol precipitation: adding an ethanol solution into the water extract, precipitating, filtering, taking filtrate, and concentrating to remove ethanol in a solvent or remove the solvent to obtain an aqueous solution of the traditional Chinese medicine composition for resisting myocardial ischemia or the traditional Chinese medicine composition for resisting myocardial ischemia. The traditional Chinese medicine composition disclosed by the invention is simple in preparation method, wide in raw material source and low in cost; the prepared traditional Chinese medicine composition has the effects of resisting rat acute myocardial ischemia caused by ISO and treating coronary heart disease.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for preparing a new drug prescription for treating myocardial ischemia. Background technique [0002] Myocardial ischemia is a pathological state in which the body's supply of blood flow to the heart is reduced, resulting in reduced oxygen supply to the heart, myocardial metabolic disorders, and the heart's inability to perform normal physiological functions. Ischemic heart disease, including angina pectoris, myocardial infarction, coronary heart disease, etc., has attracted worldwide attention because of its high prevalence and high mortality. The results of the Global Burden of Disease (GBD) study show that in 2017, there were more than 10 million new cases of ischemic heart disease worldwide, 120 million existing cases, and more than 8 million deaths, which is the first cause of death in the global population . With the improvement of the economic level ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10
CPCA61K36/22A61K36/537A61K36/185A61P9/10A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 于莹周忠光李芳菲梁浩
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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