Cone-beam X-ray fluorescence imaging method and system, terminal and storage medium

Abstract

The invention relates to a cone-beam X-ray fluorescence imaging method and system, a terminal and a storage medium. The method comprises the following steps: acquiring a phase contrast projection image of an imaging target through an X-ray phase contrast-fluorescence imaging device, and synchronously acquiring a surface fluorescence image of the imaging target; performing information separation and extraction on the phase contrast projection image to obtain an absorption contrast image, a refraction contrast image and a scattering contrast image of the imaging target, and performing three-dimensional reconstruction on the absorption contrast image, the refraction contrast image and the scattering contrast image respectively; inputting the three-dimensional reconstruction images of the absorption contrast image, the refraction contrast image and the scattering contrast image and the surface fluorescence image into the trained XLCT three-dimensional reconstruction deep convolutional neural network model, and outputting a cone beam XLCT fluorescence image of the imaging target through the XLCT three-dimensional reconstruction deep convolutional neural network model. According to the method, the ill-conditioned degree of solving the cone-beam XLCT three-dimensional reconstruction equation can be effectively reduced, and rapid and high-resolution cone-beam X-ray fluorescence imaging is realized.

Description

technical field [0001] The present application belongs to the technical field of optical molecular imaging, and in particular relates to a cone-beam X-ray fluorescence imaging method, system, terminal and storage medium. Background technique [0002] Optical molecular imaging technology is an imaging technology that uses specific molecular probes to emit light, detects optical signals from molecular markers with an optical imaging system, and restores the spatial distribution of molecular probes through algorithm reconstruction to obtain functional images of cells or tissues. . Optical molecular imaging technology is an important technical means for qualitative or quantitative research on the physiological process and pathological change process of living biological tissues at the cellular molecular level. In the past two decades, bio-optical molecular imaging technology has been rapidly developed and applied in the fields of tumor research and biopharmaceuticals. According...

AI Technical Summary

Problems solved by technology

But its disadvantage is that the scanning process is complex and cumbersome, the imaging takes a long time, and the efficiency of ray utilization is low.

The cone-beam XLCT imaging method will be the mainstream direction of XLCT imaging technology development in the future. The existing cone-beam XLCT imaging methods rely on the traditional cone-beam X-ray CT imaging to provide the structural information of the imaging sample as the prior information for XLCT reconstruction. It is impossible to provide more critical prior information such as the material composition of the sample or the distribution of charge density, so the existing cone-beam XLCT reconstruction equations still face serious ill-conditioning, which greatly limits the three-dimensional reconstruction of the cone-beam XLCT imaging method. Accuracy, it is also difficult to achieve high-quality and high-resolution cone-beam XLCT imaging of biological samples with complex structures and components

Images