Pharmaceutical composition for preventing and treating liver injury and/or liver cancer as well as preparation method and application thereof

A composition and liver injury technology, applied in the field of biomedicine, can solve problems such as liver toxicity and unsatisfactory therapeutic effect

Active Publication Date: 2021-09-14
THE AFFILIATED HOSPITAL OF TRADITIONAL CHINESE MEDICAL TO SOUTHWEST MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some traditional medicinal materials have also been found to have p

Method used

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  • Pharmaceutical composition for preventing and treating liver injury and/or liver cancer as well as preparation method and application thereof
  • Pharmaceutical composition for preventing and treating liver injury and/or liver cancer as well as preparation method and application thereof
  • Pharmaceutical composition for preventing and treating liver injury and/or liver cancer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, the preparation of pharmaceutical composition of the present invention

[0038] 【prescription】

[0039]

[0040] [Preparation method] The above fifteen flavors, forsythia, bran-fried Atractylodes macrocephala, white peony root, madder, malt, cuttlebone, vinegar turtle shell, and gallinaceous gold are mixed and pulverized into fine powder, sterilized by electric heat, and dried; cinnamon is pulverized into fine powder. powder, add ethanol to seal and keep warm, and dry; the above two fine powders are mixed with borneol and menthol and pulverized, and set aside. Add Bupleurum bupleurum, wine skullcap, astragalus, and roasted licorice with 8 times the amount of water, soak for 1 hour, decoct three times for 0.5 hours each time, filter the decoction, combine the filtrates, concentrate into a thick paste, mix with the above fine powder, and prepare Take pills, dry (60°C), select pills, pack separately, and obtain.

[0041] 【Properties】This product is a bro...

Embodiment 2

[0043] Embodiment 2, the preparation of pharmaceutical composition of the present invention

[0044] 【prescription】

[0045]

[0046] [Preparation method] The above fifteen flavors, forsythia, bran-fried Atractylodes macrocephala, white peony root, madder, malt, cuttlebone, vinegar turtle shell, and gallinaceous gold are mixed and pulverized into fine powder, sterilized by electric heat, and dried; cinnamon is pulverized into fine powder. powder, add ethanol to seal and keep warm, and dry; the above two fine powders are mixed with borneol and menthol and pulverized, and set aside. Add Bupleurum bupleurum, wine skullcap, astragalus, and roasted licorice with 8 times the amount of water, soak for 1 hour, decoct three times for 0.5 hours each time, filter the decoction, combine the filtrates, concentrate into a thick paste, mix with the above fine powder, and prepare Take pills, dry (60°C), select pills, pack separately, and obtain.

[0047] 【Properties】This product is a brown...

Embodiment 3

[0049] Embodiment 3, the preparation of pharmaceutical composition of the present invention

[0050] 【prescription】

[0051]

[0052]

[0053] [Preparation method] The above fifteen flavors, forsythia, bran-fried Atractylodes macrocephala, white peony root, madder, malt, cuttlebone, vinegar turtle shell, and gallinaceous gold are mixed and pulverized into fine powder, sterilized by electric heat, and dried; cinnamon is pulverized into fine powder. powder, add ethanol to seal and keep warm, and dry; the above two fine powders are mixed with borneol and menthol and pulverized, and set aside. Add Bupleurum bupleurum, wine skullcap, astragalus, and roasted licorice with 8 times the amount of water, soak for 1 hour, decoct three times for 0.5 hours each time, filter the decoction, combine the filtrates, concentrate into a thick paste, mix with the above fine powder, and prepare Take pills, dry (60°C), select pills, pack separately, and obtain.

[0054] 【Properties】This prod...

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Abstract

The invention provides a pharmaceutical composition for preventing and treating liver injury and/or liver cancer. The pharmaceutical composition is prepared from the following raw material medicines: 200 to 300 parts of radix bupleuri, 150 to 250 parts of radix scutellariae, 200 to 300 parts of radix astragali, 50 to 150 parts of liquorice root, 200 to 300 parts of fructus forsythiae, 100 to 200 parts of rhizoma atractylodis macrocephalae, 200 to 300 parts of radix paeoniae alba, 20 to 120 parts of radix rubiae, 20 to 120 parts of malt, 50 to 150 parts of cuttlebone, 20 to 120 parts of turtle shell, 20 to 120 parts of endothelium corneum gigeriae galli, 10 to 110 parts of cortex cinnamomi, 1 to 10 parts of borneol and 1 to 10 parts of menthol. The pharmaceutical composition disclosed by the invention is low in toxicity, can effectively prevent and treat liver injury, protect liver functions and inhibit proliferation, invasion and migration of liver cancer cells, and has a very good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to a pharmaceutical composition for preventing and treating liver damage and / or liver cancer, a preparation method and application thereof. Background technique [0002] Liver injury is caused by the damage and toxicity of metabolites in the body to liver cells, and is an acute and chronic liver disease based on liver metabolic disorders. Liver injury is a common clinical disease that endangers human health. There are 1.4 million chronic liver disease patients in the world every year. my country is a country with a high incidence of liver disease. There are about 100 million hepatitis B virus carriers and 20 million chronic hepatitis patients. [0003] There are mainly two types of pathogenic factors causing liver damage: 1. Liver inflammation caused by pathogenic microorganisms such as virus infection, such as hepatitis A and hepatitis B. 2. Chemical liver injury, that is, li...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P1/16A61P35/00A61K35/618A61K35/586A61K35/57A61K31/045
CPCA61K36/233A61K36/539A61K36/481A61K36/484A61K36/634A61K36/284A61K36/71A61K36/65A61K36/74A61K36/8998A61K35/618A61K35/586A61K35/57A61K36/54A61K31/045A61P1/16A61P35/00A61K2236/331A61K2300/00
Inventor 汪静朱晓宁蒲清荣黄锐尹玥彭昭宣彭孟云刘菊容郑丁张玉蓉
Owner THE AFFILIATED HOSPITAL OF TRADITIONAL CHINESE MEDICAL TO SOUTHWEST MEDICAL UNIV
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